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Airway responsivene...
Airway responsiveness to methacholine and incidence of COPD : an international prospective cohort study
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- Marcon, Alessandro (author)
- Univ Verona, Unit Epidemiol & Med Stat, Dept Diagnost & Publ Hlth, Verona, Italy
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- Locatelli, Francesca (author)
- Univ Verona, Unit Epidemiol & Med Stat, Dept Diagnost & Publ Hlth, Verona, Italy
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- Keidel, Dirk (author)
- Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland; Univ Basel, Basel, Switzerland
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- Beckmeyer-Borowko, Anna B. (author)
- Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland; Univ Basel, Basel, Switzerland
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- Cerveri, Isa (author)
- Univ Pavia, IRCCS, San Matteo Hosp Fdn, Pavia, Italy
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- Dharmage, Shyamali C. (author)
- Univ Melbourne, Allergy & Lung Hlth Unit, Sch Populat & Global Hlth, Parkville, Vic, Australia
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- Fuertes, Elaine (author)
- Ctr Res Environm Epidemiol CREAL, Inst Global Hlth ISGlobal, Barcelona, Spain; UPF, Barcelona, Spain; CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain
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- Garcia-Aymerich, Judith (author)
- Ctr Res Environm Epidemiol CREAL, Inst Global Hlth ISGlobal, Barcelona, Spain; UPF, Barcelona, Spain; CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain
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- Heinrich, Joachim (author)
- Ludwig Maximilians Univ Munchen, Inst & Outpatient Clin Occupat Social & Environm, Univ Hosp, Munich, Germany; German Ctr Lung Res, Comprehens Pneumol Ctr Munich, Munich, Germany
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- Imboden, Medea (author)
- Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland; Univ Basel, Basel, Switzerland
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- Janson, Christer (author)
- Uppsala universitet,Lung- allergi- och sömnforskning
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- Johannessen, Ane (author)
- Univ Bergen, Dept Global Publ Hlth & Primary Care, Ctr Int Hlth, Bergen, Norway
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- Leynaert, Benedicte (author)
- Univ Paris Diderot Paris 7, INSERM, UMR 1152, Pathophysiol & Epidemiol Resp Dis, Paris, France
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- Erquicia, Silvia Pascual (author)
- Galdakao Hosp, Resp Dept, OSI Barrualde Galdakao, Biscay, Spain
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- Pesce, Giancarlo (author)
- Univ Verona, Unit Epidemiol & Med Stat, Dept Diagnost & Publ Hlth, Verona, Italy
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- Schaffner, Emmanuel (author)
- Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland; Univ Basel, Basel, Switzerland
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- Svanes, Cecilie (author)
- Univ Bergen, Dept Global Publ Hlth & Primary Care, Ctr Int Hlth, Bergen, Norway; Haukeland Hosp, Dept Occupat Med, Bergen, Norway
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- Urrutia, Isabel (author)
- Galdakao Hosp, Resp Dept, OSI Barrualde Galdakao, Biscay, Spain
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- Jarvis, Deborah (author)
- Imperial Coll London, MRC PHE Ctr Environm & Hlth, London, England; Imperial Coll London, Populat Hlth & Occupat Dis, Natl Heart & Lung Inst, London, England
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- Probst-Hensch, Nicole M. (author)
- Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland; Univ Basel, Basel, Switzerland
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- Accordini, Simone (author)
- Univ Verona, Unit Epidemiol & Med Stat, Dept Diagnost & Publ Hlth, Verona, Italy
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(creator_code:org_t)
- 2018-05-02
- 2018
- English.
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In: Thorax. - : BMJ PUBLISHING GROUP. - 0040-6376 .- 1468-3296. ; 73:9, s. 825-832
- Related links:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://thorax.bmj.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: It has been debated, but not yet established, whether increased airway responsiveness can predict COPD. Recognising this link may help in identifying subjects at risk.Objective: We studied prospectively whether airway responsiveness is associated with the risk of developing COPD.Methods: We pooled data from two multicentre cohort studies that collected data from three time points using similar methods (European Community Respiratory Health Survey and Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults). We classified subjects (median age 37 years, 1st–3rd quartiles: 29–44) by their level of airway responsiveness using quintiles of methacholine dose–response slope at the first examination (1991–1994). Then, we excluded subjects with airflow obstruction at the second examination (1999–2003) and analysed incidence of COPD (postbronchodilator FEV1/FVC below the lower limit of normal) at the third examination (2010–2014) as a function of responsiveness, adjusting for sex, age, education, body mass index, history of asthma, smoking, occupational exposures and indicators of airway calibre.Results: We observed 108 new cases of COPD among 4205 subjects during a median time of 9 years. Compared with the least responsive group (incidence rate 0.6 per 1000/year), adjusted incidence rate ratios for COPD ranged from 1.79 (95% CI 0.52 to 6.13) to 8.91 (95% CI 3.67 to 21.66) for increasing airway responsiveness. Similar dose–response associations were observed between smokers and non-smokers, and stronger associations were found among subjects without a history of asthma or asthma-like symptoms.Conclusions: Our study suggests that increased airway responsiveness is an independent risk factor for COPD. Further research should clarify whether early treatment in patients with high responsiveness can slow down disease progression.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
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Marcon, Alessand ...
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Locatelli, Franc ...
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Keidel, Dirk
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Beckmeyer-Borowk ...
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Cerveri, Isa
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Dharmage, Shyama ...
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Fuertes, Elaine
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Garcia-Aymerich, ...
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Heinrich, Joachi ...
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Imboden, Medea
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Janson, Christer
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Johannessen, Ane
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Leynaert, Benedi ...
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Erquicia, Silvia ...
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Pesce, Giancarlo
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Schaffner, Emman ...
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Svanes, Cecilie
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Urrutia, Isabel
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Jarvis, Deborah
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Probst-Hensch, N ...
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Accordini, Simon ...
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Thorax
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Uppsala University