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Serum Parathyroid H...
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Larsson, Susanna CKarolinska Institutet,Uppsala universitet,Ortopedi
(författare)
Serum Parathyroid Hormone, 25-Hydroxyvitamin D, and Risk of Alzheimer's Disease : A Mendelian Randomization Study
- Artikel/kapitelEngelska2018
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2018-09-06
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MDPI AG,2018
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LIBRIS-ID:oai:DiVA.org:uu-367525
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-367525URI
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https://doi.org/10.3390/nu10091243DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:139528429URI
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Språk:engelska
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Sammanfattning på:engelska
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We conducted Mendelian randomization analyses to investigate the associations of serum parathyroid hormone (S-PTH) and serum 25-hydroxyvitamin D (S-25OHD) concentrations with Alzheimer's disease (AD). Five and seven single nucleotide polymorphisms associated with S-PTH and S-25OHD concentrations, respectively, were used as instrumental variables. Data for AD were acquired from the International Genomics of Alzheimer's Project (17,008 AD cases and 37,154 controls). Genetically higher S-PTH concentrations were not associated with AD (odds ratio per standard deviation increase in S-PTH = 1.11; 95% CI 0.97-1.26; p = 0.12). In contrast, all seven 25OHD-increasing alleles were inversely associated with AD and two of the associations were statistically significant (p < 0.05). The odds ratio of AD per genetically-predicted one standard deviation increase in S-25OHD was 0.86 (95% CI 0.78-0.94; p = 0.002). This study provides evidence that vitamin D may play a role in AD but found no significant association between S-PTH and AD.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Traylor, MatthewUniv Cambridge, Dept Clin Neurosci, Stroke Res Grp, Cambridge, England
(författare)
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Markus, Hugh SUniv Cambridge, Dept Clin Neurosci, Stroke Res Grp, Cambridge, England
(författare)
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Michaëlsson, Karl,1959-Uppsala universitet,Ortopedi(Swepub:uu)karlmich
(författare)
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Uppsala universitetOrtopedi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Nutrients: MDPI AG10:92072-6643
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