Sökning: onr:"swepub:oai:DiVA.org:uu-372445" >
SCOT :
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Robles-Zurita, JoseUniv Glasgow, Inst Hlth & Wellbeing, Glasgow, Lanark, Scotland
(författare)
SCOT : a comparison of cost-effectiveness from a large randomised phase III trial of two durations of adjuvant Oxaliplatin combination chemotherapy for colorectal cancer
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
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2018-11-13
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Springer Science and Business Media LLC,2018
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-372445
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-372445URI
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https://doi.org/10.1038/s41416-018-0319-zDOI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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BACKGROUND: The Short Course Oncology Therapy (SCOT) study is an international, multicentre, non-inferiority randomised controlled trial assessing the efficacy, toxicity, and cost-effectiveness of 3 months (3 M) versus the usually given 6 months (6 M) of adjuvant chemotherapy in colorectal cancer.METHODS: In total, 6088 patients with fully resected high-risk stage II or stage III colorectal cancer were randomised and followed up for 3-8 years. The within-trial cost-effectiveness analysis from a UK health-care perspective is presented using the resource use data, quality of life (EQ-5D-3L), time on treatment (ToT), disease-free survival after treatment (DFS) and overall survival (OS) data. Quality-adjusted partitioned survival analysis and Kaplan-Meier Sample Average Estimator estimated QALYs and costs. Probabilistic sensitivity and subgroup analysis was undertaken.RESULTS: The 3M arm is less costly (-4881; pound 95% CI: -6269; pound -3492) pound and entails (non-significant) QALY gains (0.08; 95% CI: -0.086; 0.230) due to a better significant quality of life. The net monetary benefit was significantly higher in 3M under a wide range of monetary values of a QALY. The subgroup analysis found similar results for patients in the CAPOX regimen. However, for the FOLFOX regimen, 3M had lower QALYs than 6M (not statistically significant).CONCLUSIONS: Overall, 3M dominates 6M with no significant detrimental impact on QALYs. The results provide the economic case that a 3M treatment strategy should be considered a new standard of care.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Boyd, Kathleen A.Univ Glasgow, Inst Hlth & Wellbeing, Glasgow, Lanark, Scotland
(författare)
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Briggs, Andrew H.Univ Glasgow, Inst Hlth & Wellbeing, Glasgow, Lanark, Scotland
(författare)
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Iveson, TimothySouthampton Univ Hosp NHS Fdn Trust, Southampton, Hants, England
(författare)
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Kerr, Rachel S.Univ Oxford, Dept Oncol, Oxford, England
(författare)
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Saunders, Mark P.Christie Hosp, Manchester, Lancs, England
(författare)
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Cassidy, JimUniv Glasgow, Inst Canc Sci, Canc Res UK Clin Trials Unit, Glasgow, Lanark, Scotland
(författare)
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Hollander, Niels HenrikZealand Univ Hosp, Dept Oncol & Palliat Care, Radmandsengen 5, DK-4700 Naestved, Denmark
(författare)
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Tabernero, JosepUniv Autonoma Barcelona, CIBERONC, Vall dHebron Univ Hosp, Barcelona, Spain;Univ Autonoma Barcelona, CIBERONC, Inst Oncol VHIO, Barcelona, Spain
(författare)
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Segelov, EvaAustralasian Gastrointestinal Trials Grp AGITG, Melbourne, Vic, Australia;Monash Univ, Melbourne, Vic, Australia;Monash Hlth, Melbourne, Vic, Australia
(författare)
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Glimelius, BengtUppsala universitet,Experimentell och klinisk onkologi(Swepub:uu)bengglim
(författare)
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Harkin, AndreaUniv Glasgow, Inst Canc Sci, Canc Res UK Clin Trials Unit, Glasgow, Lanark, Scotland
(författare)
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Allan, KarenUniv Glasgow, Inst Canc Sci, Canc Res UK Clin Trials Unit, Glasgow, Lanark, Scotland
(författare)
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McQueen, JohnUniv Glasgow, Inst Canc Sci, Canc Res UK Clin Trials Unit, Glasgow, Lanark, Scotland
(författare)
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Pearson, SarahUniv Oxford, OCTO, Dept Oncol, Oxford, England
(författare)
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Waterston, AshitaBeatson West Scotland Canc Ctr, Glasgow, Lanark, Scotland
(författare)
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Medley, LouiseRoyal United Hosp, Bath, Avon, England
(författare)
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Wilson, CharlesAddenbrookes Hosp, Cambridge, England
(författare)
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Ellis, RichardRoyal Cornwall Hosp NHS Trust, Truro, Cornwall, England
(författare)
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Essapen, SharadahRoyal Surrey Cty Hosp NHS Fdn Trust, St Lukes Canc Ctr, Guildford, Surrey, England
(författare)
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Dhadda, Amandeep S.Castle Hill Hosp, Kingston Upon Hull, N Humberside, England
(författare)
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Hughes, RobMt Vernon Canc Ctr, Northwood, Middx, England
(författare)
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Falk, StephenBristol Canc Inst, Bristol, Avon, England
(författare)
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Raouf, SherifBarking Havering & Redbridge Univ Hosp NHS Trust, Barking, England
(författare)
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Rees, CharlotteSouthampton Univ Hosp NHS Fdn Trust, Southampton, Hants, England
(författare)
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Olesen, Rene K.Zealand Univ Hosp, Dept Oncol & Palliat Care, Radmandsengen 5, DK-4700 Naestved, Denmark
(författare)
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Propper, DavidQueen Mary Univ London, Barts Canc Inst, London, England
(författare)
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Bridgewater, JohnUCL, London, England
(författare)
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Azzabi, AshrafNewcastle Upon Tyne Hosp NHS Fdn Trust, Newcastle Upon Tyne, Tyne & Wear, England
(författare)
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Farrugia, DavidCheltenham Gen Hosp, Gloucestershire Oncol Ctr, Cheltenham, Glos, England
(författare)
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Webb, AndrewBrighton & Sussex Univ Hosp Trust, Brighton, E Sussex, England
(författare)
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Cunningham, DavidRoyal Marsden, London, England
(författare)
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Hickish, TamasBournemouth Univ, Poole Hosp, Bournemouth, Dorset, England
(författare)
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Weaver, AndrewOxford Univ Hosp Fdn Trust, Churchill Hosp, Oxford, England
(författare)
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Gollins, SimonNorth Wales Canc Treatment Ctr, Rhyl, Wales
(författare)
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Wasan, Harpreet S.Imperial Coll London, Hammersmith Hosp, London, England
(författare)
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Paul, JamesUniv Glasgow, Inst Canc Sci, Canc Res UK Clin Trials Unit, Glasgow, Lanark, Scotland
(författare)
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Univ Glasgow, Inst Hlth & Wellbeing, Glasgow, Lanark, ScotlandSouthampton Univ Hosp NHS Fdn Trust, Southampton, Hants, England
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:British Journal of Cancer: Springer Science and Business Media LLC119:11, s. 1332-13380007-09201532-1827
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Till lärosätets databas
- Av författaren/redakt...
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Robles-Zurita, J ...
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Boyd, Kathleen A ...
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Briggs, Andrew H ...
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Iveson, Timothy
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Kerr, Rachel S.
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Saunders, Mark P ...
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visa fler...
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Cassidy, Jim
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Hollander, Niels ...
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Tabernero, Josep
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Segelov, Eva
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Glimelius, Bengt
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Harkin, Andrea
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Allan, Karen
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McQueen, John
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Pearson, Sarah
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Waterston, Ashit ...
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Medley, Louise
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Wilson, Charles
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Ellis, Richard
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Essapen, Sharada ...
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Dhadda, Amandeep ...
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Hughes, Rob
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Falk, Stephen
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Raouf, Sherif
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Rees, Charlotte
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Olesen, Rene K.
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Propper, David
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Bridgewater, Joh ...
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Azzabi, Ashraf
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Farrugia, David
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Webb, Andrew
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Cunningham, Davi ...
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Hickish, Tamas
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Weaver, Andrew
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Gollins, Simon
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Wasan, Harpreet ...
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Paul, James
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visa färre...
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