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A critical survey of the structure-function of the antisense oligo/RNA heteroduplex as substrate for RNase H

Zamaratski, E (author)
Uppsala universitet,Institutionen för bioorganisk kemi
Pradeepkumar, PI (author)
Chattopadhyaya, J (author)
 (creator_code:org_t)
ELSEVIER SCIENCE BV, 2001
2001
English.
In: JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS. - : ELSEVIER SCIENCE BV. ; 48:3, s. 189-208
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  • The aim of this review is to draw a correlation between the structure of the DNA/RNA hybrid and its properties as a substrate for the RNase H, as well as to point the crucial structural requirements for the modified AONs to preserve their RNase H potency.

Keyword

structure; DNA/RNA hybrid; AONs; RNase H; COLI RIBONUCLEASE HI; ALKYLATING OLIGONUCLEOTIDE DERIVATIVES; ARABINONUCLEIC ACIDS ANA; LOCKED NUCLEIC-ACID; ESCHERICHIA-COLI; DNA-REPLICATION; HYBRID DUPLEXES; MESSENGER-RNA; THERAPEUTIC AGENTS; COMPLEMENTARY RNA

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