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A critical survey o...
A critical survey of the structure-function of the antisense oligo/RNA heteroduplex as substrate for RNase H
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- Zamaratski, E (author)
- Uppsala universitet,Institutionen för bioorganisk kemi
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Pradeepkumar, PI (author)
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Chattopadhyaya, J (author)
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(creator_code:org_t)
- ELSEVIER SCIENCE BV, 2001
- 2001
- English.
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In: JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS. - : ELSEVIER SCIENCE BV. ; 48:3, s. 189-208
- Related links:
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https://urn.kb.se/re...
Abstract
Subject headings
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- The aim of this review is to draw a correlation between the structure of the DNA/RNA hybrid and its properties as a substrate for the RNase H, as well as to point the crucial structural requirements for the modified AONs to preserve their RNase H potency.
Keyword
- structure; DNA/RNA hybrid; AONs; RNase H; COLI RIBONUCLEASE HI; ALKYLATING OLIGONUCLEOTIDE DERIVATIVES; ARABINONUCLEIC ACIDS ANA; LOCKED NUCLEIC-ACID; ESCHERICHIA-COLI; DNA-REPLICATION; HYBRID DUPLEXES; MESSENGER-RNA; THERAPEUTIC AGENTS; COMPLEMENTARY RNA
Publication and Content Type
- vet (subject category)
- rec (subject category)
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