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SPCG-15 :
SPCG-15 : a prospective randomized study comparing primary radical prostatectomy and primary radiotherapy plus androgen deprivation therapy for locally advanced prostate cancer
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- Stranne, Johan, 1970 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology
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- Brasso, K. (författare)
- Rigshosp Copenhagen, Copenhagen Prostate Canc Ctr, Copenhagen, Denmark; Rigshosp Copenhagen, Dept Urol, Copenhagen, Denmark
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- Brennhovd, B. (författare)
- Oslo Univ Hosp HF, Dept Urooncol, Radiumhosp, Oslo, Norway
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- Johansson, Eva (författare)
- Uppsala universitet,Urologkirurgi
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- Jäderling, F. (författare)
- Karolinska Institutet
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- Kouri, M. (författare)
- Helsinki Univ Hosp, Dept Oncol, Helsinki, Finland
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- Lilleby, W. (författare)
- Oslo Univ Hosp HF, Dept Urooncol, Radiumhosp, Oslo, Norway
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- Petersen, P. Meidahl (författare)
- Copenhagen Univ Hosp, Dept Oncol, Finsen Ctr, Copenhagen, Denmark
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- Mirtti, T. (författare)
- Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland
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- Pettersson, A. (författare)
- Karolinska Institutet
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- Rannikko, A. (författare)
- Helsinki Univ Hosp, Dept Urol, Helsinki, Finland
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- Thellenberg, C. (författare)
- Norrlands Univ Hosp, Cancerctr, Umeå, Sweden
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- Akre, O. (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2018-12-26
- 2018
- Engelska.
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Ingår i: Scandinavian journal of urology. - : Medical Journals Sweden AB. - 2168-1805 .- 2168-1813. ; 52:5-6, s. 313-320
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- Objective: To describe study design and procedures for a prospective randomized trial investigating whether radical prostatectomy (RP) ± radiation improves cause-specific survival in comparison with primary radiation treatment (RT) and androgen deprivation treatment (ADT) in patients with locally advanced prostate cancer (LAPC).Materials and methods: SPCG-15 is a prospective, multi-centre, open randomized phase III trial. Patients are randomized to either standard (RT + ADT) or experimental (RP with extended pelvic lymph-node dissection and with addition of adjuvant or salvage RT and/or ADT if deemed necessary) treatment. Each centre follows guidelines regarding the timing and dosing of postoperative RT and adjuvant treatment such as ADT The primary endpoint is cause-specific survival. Secondary endpoints include metastasis-free and overall survival, quality-of-life, functional outcomes and health-services requirements. Each subject will be followed up for a minimum of 10 years.Results: Twenty-three centres in Denmark, Finland, Norway and Sweden, well established in performing RP and RT for prostate cancer participated. Each country’s sites were coordinated by national coordinating investigators and sub-investigators for urology and oncology. Almost 400 men have been randomized of the stipulated 1200, with an increasing rate of accrual.Conclusions: The SPCG-15 trial aims to compare the two curatively intended techniques supplying new knowledge to support future decisions in treatment strategies for patients with LAPC The Scandinavian healthcare context is well suited for performing multi-centre long-term prospective randomized clinical trials. Similar care protocols and a history of entirely tax-funded healthcare facilitate joint trials.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- Locally advanced prostate cancer
- radical prostatectomy
- radiotherapy
- androgen deprivation therapy
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Stranne, Johan, ...
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Brasso, K.
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Brennhovd, B.
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Johansson, Eva
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Jäderling, F.
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Kouri, M.
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Lilleby, W.
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Petersen, P. Mei ...
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Mirtti, T.
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Pettersson, A.
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Rannikko, A.
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Thellenberg, C.
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Akre, O.
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Urologi och njur ...
- Artiklar i publikationen
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Scandinavian jou ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet
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Göteborgs universitet