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Experimentally redu...
Experimentally reduced insulin/IGF‐1 signaling in adulthood extends lifespan of parents and improves Darwinian fitness of their offspring
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- Lind, Martin I., Dr (författare)
- Uppsala universitet,Zooekologi,Uppsala University, Uppsala, Sweden
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- Ravindran, Sanjana (författare)
- Uppsala universitet,Zooekologi
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- Sekajova, Zuzana (författare)
- Uppsala universitet,Zooekologi
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- Carlsson, Hanne (författare)
- Uppsala universitet,Zooekologi,Univ East Anglia, Sch Biol Sci, Norwich, Norfolk, England
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- Hinas, Andrea (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Maklakov, Alex A. (författare)
- Uppsala universitet,Zooekologi,Univ East Anglia, Sch Biol Sci, Norwich, Norfolk, England
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(creator_code:org_t)
- 2019-03-04
- 2019
- Engelska.
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Ingår i: Evolution Letters. - : Oxford University Press (OUP). - 2056-3744. ; 3:2, s. 207-216
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Classical theory maintains that ageing evolves via energy trade-offs between reproduction and survival leading to accumulation of unrepaired cellular damage with age. In contrast, the emerging new theory postulates that ageing evolves because of deleterious late-life hyper-function of reproduction-promoting genes leading to excessive biosynthesis in late-life. The hyper-function theory uniquely predicts that optimizing nutrient-sensing molecular signaling in adulthood can simultaneously postpone ageing and increase Darwinian fitness. Here, we show that reducing evolutionarily conserved insulin/IGF-1 nutrient-sensing signaling via daf-2 RNA interference (RNAi) fulfils this prediction in Caenorhabditis elegans nematodes. Long-lived daf-2 RNAi parents showed normal fecundity as self-fertilizing hermaphrodites and improved late-life reproduction when mated to males. Remarkably, the offspring of daf-2 RNAi parents had higher Darwinian fitness across three different genotypes. Thus, reduced nutrient-sensing signaling in adulthood improves both parental longevity and offspring fitness supporting the emerging view that suboptimal gene expression in late-life lies at the heart of ageing.
Ämnesord
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
- NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
Nyckelord
- Ageing
- antagonistic pleiotropy
- functional trade-offs
- hyperfunction
- IIS signaling
- parental effects
- senescence
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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