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Carbon nanotube dop...
Carbon nanotube doped pericardial matrix derived electroconductive biohybrid hydrogel for cardiac tissue engineering
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- Roshanbinfar, Kaveh (author)
- Friedrich Alexander Univ Erlangen Nurnberg FAU, Inst Pathol, Dept Nephropathol, Expt Renal & Cardiovasc Res, D-91054 Erlangen, Germany;Muscle Res Ctr Erlangen MURCE, D-91054 Erlangen, Germany;Univ Tehran, Fac New Sci & Technol, Biomed Engn Dept, Biomat Grp,Bioceram Lab, Tehran 1439957131, Iran
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- Mohammadi, Zahra (author)
- Univ Tehran, Fac New Sci & Technol, Biomed Engn Dept, Biomat Grp,Bioceram Lab, Tehran 1439957131, Iran
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- Mesgar, Abdorreza Sheikh-Mandi (author)
- Univ Tehran, Fac New Sci & Technol, Biomed Engn Dept, Biomat Grp,Bioceram Lab, Tehran 1439957131, Iran
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- Dehghan, Mohammad Mehdi (author)
- Univ Tehran, Fac Vet Med, Dept Surg & Radiol, Tehran 1417466191, Iran
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- Oommen, Oommen P. (author)
- Tampere Univ Technol, Bioengn & Nanomed Lab, Fac Biomed Sci & Engn, Tampere 33720, Finland;BioMediTech Inst, Tampere 33720, Finland
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- Hilborn, Jöns, 1956- (author)
- Uppsala universitet,Institutionen för kemi - Ångström
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- Engel, Felix B. (author)
- Friedrich Alexander Univ Erlangen Nurnberg FAU, Inst Pathol, Dept Nephropathol, Expt Renal & Cardiovasc Res, D-91054 Erlangen, Germany;Muscle Res Ctr Erlangen MURCE, D-91054 Erlangen, Germany
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(creator_code:org_t)
- 2019
- 2019
- English.
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In: Biomaterials Science. - : ROYAL SOC CHEMISTRY. - 2047-4830 .- 2047-4849. ; 7:9, s. 3906-3917
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Cardiovascular diseases represent a major socio-economic burden. In recent years, considerable effort has been invested in optimizing cell delivery strategies to advance cell transplantation therapies to restore heart function for example after an infarct. A particular issue is that the implantation of cells using a non-electroconductive matrix potentially causes arrhythmia. Here, we demonstrate that our hydrazide-functionalized nanotubes-pericardial matrix-derived electroconductive biohybrid hydrogel provides a suitable environment for maturation of human-induced pluripotent stem cell (hiPSC)-derived cardiomyocytes. hiPSC-derived cardiomyocytes exhibited an improved contraction amplitude (>500%) on conductive hydrogels compared to cells cultured on Matrigel (R). This was accompanied by increased cellular alignment, enhanced connexin 43 expression, and improved sarcomere organization suggesting maturation of the hiPSC-derived cardiomyocytes. Sarcomeric length of these cells increased from 1.3 to 1.7 mu m. Moreover, 3D cell-laden engineered tissues exhibited enhanced calcium handling as well as positive response to external electrical and pharmaceutical stimulation. Collectively, our data indicate that our biohybrid hydrogels consisting of solubilized nanostructured pericardial matrix and electroconductive positively charged hydrazide-conjugated carbon nanotubes provide a promising material for stem cell-based cardiac tissue engineering.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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