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Coagulation Factor ...
Coagulation Factor Xa Promotes Solid Tumor Growth, Experimental Metastasis and Endothelial Cell Activation
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- Arce, Maximiliano (author)
- Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile;Adv Ctr Chron Dis ACCDiS, Santiago, Chile
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- Pinto, Mauricio P. (author)
- Pontificia Univ Catolica Chile, Fac Med, Santiago 8331150, Chile
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- Galleguillos, Macarena (author)
- Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile
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- Munoz, Catalina (author)
- Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile
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- Lange, Soledad (author)
- Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile
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- Ramirez, Carolina (author)
- Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile
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- Erices, Rafaela (author)
- Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile;Univ Mayor, Vicerrectoria Invest, Santiago 7510041, Chile
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- Gonzalez, Pamela (author)
- Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile
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- Velasquez, Ethel (author)
- Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile;Comis Chilena Energia Nucl CCHEN, Santiago, Chile
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- Tempio, Fabian (author)
- Univ Chile, Fac Med, Inst Biomed Sci, Santiago 8380453, Chile
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- Lopez, Mercedes N. (author)
- Univ Chile, Fac Med, Inst Biomed Sci, Santiago 8380453, Chile;Millennium Inst Immunol & Immunotherapy, Santiago 8331150, Chile
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- Salazar-Onfray, Flavio (author)
- Univ Chile, Fac Med, Inst Biomed Sci, Santiago 8380453, Chile;Millennium Inst Immunol & Immunotherapy, Santiago 8331150, Chile
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- Cautivo, Kelly (author)
- Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile
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- Kalergis, Alexis M. (author)
- Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile;Millennium Inst Immunol & Immunotherapy, Santiago 8331150, Chile;Biomed Res Consortium Chile, Santiago 8331010, Chile
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- Cruz, Sebastian (author)
- Fdn Ciencia & Vida, Lab Immunoncol, Santiago, Chile
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- Lladser, Alvaro (author)
- Millennium Inst Immunol & Immunotherapy, Santiago 8331150, Chile;Fdn Ciencia & Vida, Lab Immunoncol, Santiago, Chile
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- Lobos-Gonzalez, Lorena (author)
- Adv Ctr Chron Dis ACCDiS, Santiago, Chile;Fdn Ciencia & Vida, Lab Immunoncol, Santiago, Chile;Univ Desarrollo, Fac Med, Regenerat Med Ctr, Clin Alemana, Santiago 7650568, Chile
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- Valenzuela, Guillermo (author)
- Pontificia Univ Catolica Chile, Fac Med, Santiago 8331150, Chile
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- Olivares, Nixa (author)
- Pontificia Univ Catolica Chile, Fac Med, Santiago 8331150, Chile
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- Saez, Claudia (author)
- Pontificia Univ Catolica Chile, Fac Med, Santiago 8331150, Chile
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- Koning, Tania (author)
- Univ Austral Chile, Fac Med, Immunol Inst, Valdivia 5110566, Chile
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- Sanchez, Fabiola A. (author)
- Univ Austral Chile, Fac Med, Immunol Inst, Valdivia 5110566, Chile
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- Fuenzalida, Patricia (author)
- Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile
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- Godoy, Alejandro (author)
- Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile;Roswell Pk Comprehens Canc Ctr, Dept Urol, Buffalo, NY 14203 USA
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- Contreras Orellana, Pamela (author)
- Adv Ctr Chron Dis ACCDiS, Santiago, Chile;Univ Chile, Fac Med, Lab Cellular Commun, ICBM, Santiago 8380453, Chile
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- Leyton, Lisette (author)
- Adv Ctr Chron Dis ACCDiS, Santiago, Chile;Univ Chile, Fac Med, Lab Cellular Commun, ICBM, Santiago 8380453, Chile
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- Lugano, Roberta (author)
- Uppsala universitet,Vaskulärbiologi
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- Dimberg, Anna (author)
- Uppsala universitet,Vaskulärbiologi
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- Quest, Andrew F. G. (author)
- Adv Ctr Chron Dis ACCDiS, Santiago, Chile;Univ Chile, Fac Med, Lab Cellular Commun, ICBM, Santiago 8380453, Chile
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- Owen, Gareth, I (author)
- Pontificia Univ Catolica Chile, Fac Biol Sci, Santiago 8331150, Chile;Adv Ctr Chron Dis ACCDiS, Santiago, Chile;Pontificia Univ Catolica Chile, Fac Med, Santiago 8331150, Chile;Millennium Inst Immunol & Immunotherapy, Santiago 8331150, Chile
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(creator_code:org_t)
- 2019-08-02
- 2019
- English.
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In: Cancers. - : MDPI. - 2072-6694. ; 11:8
- Related links:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Subject headings
Close
- Hypercoagulable state is linked to cancer progression; however, the precise role of the coagulation cascade is poorly described. Herein, we examined the contribution of a hypercoagulative state through the administration of intravenous Coagulation Factor Xa (FXa), on the growth of solid human tumors and the experimental metastasis of the B16F10 melanoma in mouse models. FXa increased solid tumor volume and lung, liver, kidney and lymph node metastasis of tail-vein injected B16F10 cells. Concentrating on the metastasis model, upon coadministration of the anticoagulant Dalteparin, lung metastasis was significantly reduced, and no metastasis was observed in other organs. FXa did not directly alter proliferation, migration or invasion of cancer cells in vitro. Alternatively, FXa upon endothelial cells promoted cytoskeleton contraction, disrupted membrane VE-Cadherin pattern, heightened endothelial-hyperpermeability, increased inflammatory adhesion molecules and enhanced B16F10 adhesion under flow conditions. Microarray analysis of endothelial cells treated with FXa demonstrated elevated expression of inflammatory transcripts. Accordingly, FXa treatment increased immune cell infiltration in mouse lungs, an effect reduced by dalteparin. Taken together, our results suggest that FXa increases B16F10 metastasis via endothelial cell activation and enhanced cancer cell-endothelium adhesion advocating that the coagulation system is not merely a bystander in the process of cancer metastasis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- cancer
- metastasis
- melanoma
- blood coagulation
- vascular endothelium
- inflammation
Publication and Content Type
- ref (subject category)
- art (subject category)
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Cancers
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- By the author/editor
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Arce, Maximilian ...
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Pinto, Mauricio ...
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Galleguillos, Ma ...
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Munoz, Catalina
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Lange, Soledad
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Ramirez, Carolin ...
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show more...
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Erices, Rafaela
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Gonzalez, Pamela
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Velasquez, Ethel
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Tempio, Fabian
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Lopez, Mercedes ...
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Salazar-Onfray, ...
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Cautivo, Kelly
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Kalergis, Alexis ...
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Cruz, Sebastian
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Lladser, Alvaro
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Lobos-Gonzalez, ...
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Valenzuela, Guil ...
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Olivares, Nixa
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Saez, Claudia
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Koning, Tania
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Sanchez, Fabiola ...
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Fuenzalida, Patr ...
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Godoy, Alejandro
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Contreras Orella ...
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Leyton, Lisette
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Lugano, Roberta
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Dimberg, Anna
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Quest, Andrew F. ...
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Owen, Gareth, I
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancers
- By the university
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Uppsala University