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Effects of pneumoperitoneum on splanchnic hemodynamics : an experimental study in pigs.
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- Rasmussen, Ib (author)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper
- Berggren, U (author)
- Arvidsson, D (author)
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- Ljungdahl, M (author)
- Haglund, U (author)
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- (creator_code:org_t)
- 1995
- 1995
- English.
- In: European Journal of Surgery. - 1102-4151 .- 1741-9271. ; 161:11, s. 819-26
- Journal article (peer-reviewed)
Abstract
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- OBJECTIVE: To study the effects on splanchnic haemodynamics of pneumoperitoneum induced by carbon dioxide insufflation.DESIGN: Controlled experimental study.ANIMALS: 11 Pigs weighing 19-30 kg.INTERVENTION: The animals were divided into a control group (n = 4) and a experimental group (n = 7). Experimental animals were subjected to stepwise increasing intra-abdominal pressure from 0 mm Hg to 25 mm Hg by carbon dioxide insufflation.MAIN OUTCOME MEASURES: Portal venous blood flow, portal venous blood pressure, portal/hepatic vascular resistance, and gastrointestinal vascular resistance.RESULTS: At 25 mm Hg portal venous blood flow was reduced (66% of baseline), and portal venous blood pressure and portal/hepatic vascular resistance were increased (360% and 650% of baseline, respectively). The increase in gastrointestinal vascular resistance was less pronounced.CONCLUSIONS: Increased intra-abdominal pressure caused significant changes in the splanchnic haemodynamics. The risk was greater if the intra-abdominal pressure exceeded 15 mm Hg.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Andra medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Other Basic Medicine (hsv//eng)
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