Enhanced ventricular-arterial coupling during a 2-year physical activity programme in patients with rheumatoid arthritis: a prospective substudy of the physical activity in rheumatoid arthritis 2010 trial.

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Sarajlic, PKarolinska Institutet (author)

Enhanced ventricular-arterial coupling during a 2-year physical activity programme in patients with rheumatoid arthritis : a prospective substudy of the physical activity in rheumatoid arthritis 2010 trial.

Article/chapterEnglish2018

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2017-12-13
Wiley,2018
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:uu-397268
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-397268URI
https://doi.org/10.1111/joim.12715DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:139644951URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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OBJECTIVE: To establish how guided physical activity in patients with rheumatoid arthritis (RA) without known cardiovascular disease affected vascular and cardiac function, and how these two entities were prospectively interconnected in this patient group.METHODS: Prospective substudy of 29 participants in the Physical Activity in RA (PARA) 2010 trial. All subjects were examined at baseline, at year 1 and 2 with measures of pulse wave velocity and arterial augmentation index, as well as echocardiographic evaluation of diastolic parameters and ventricular-arterial coupling. Muscle strength and aerobic exercise capacity were assessed at baseline and yearly. All participants performed physiotherapist-guided aerobic and muscle strength exercise during 2 years and were reminded through SMS to report physical activity progress.RESULTS: This cohort of patients with RA exhibited increased vascular stiffness despite normal blood pressure. At baseline, lower muscle strength was associated with increased vascular stiffness (β = 0.68; P = 0.004), whereas lower aerobic working capacity was associated with left ventricular diastolic dysfunction (β = 0.85; P = 0.03). There was a significant positive correlation between vascular stiffness and diastolic dysfunction at baseline (R2 = 0.64) and for the changes in those parameters observed during 2 years of guided physical activity. Finally, a significant improvement in ventricular-arterial coupling was observed after exercise (P < 0.001).CONCLUSION: These results indicate that although differentially associated with physical capacity parameters, improved vascular stiffness and improved diastolic dysfunction are interrelated, and that an optimization of the ventricular-arterial coupling may contribute to the beneficial effects of physical activity in patients with RA.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Sjukgymnastik hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Physiotherapy hsv//eng
augmentation index
echocardiography
inflammation
pulse wave velocity

Added entries (persons, corporate bodies, meetings, titles ...)

Fridén, CKarolinska Institutet (author)
Lund, L HKarolinska Institutet (author)
Manouras, AKarolinska Institutet (author)
Venkateshvaran, AKarolinska Institutet (author)
Larsson, Susanna C.Karolinska Institutet,Uppsala universitet,Ortopedi(Swepub:uu)susla720 (author)
Nordgren, BKarolinska Institutet (author)
Opava, C HKarolinska Institutet (author)
Lundberg, I EKarolinska Institutet (author)
Bäck, MKarolinska Institutet (author)
Karolinska InstitutetOrtopedi (creator_code:org_t)

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In:Journal of Internal Medicine: Wiley284:6, s. 664-6730954-68201365-2796

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By the author/editor: Sarajlic, P; Fridén, C; Lund, L H; Manouras, A; Venkateshvaran, ...; Larsson, Susanna ...; show more...; Nordgren, B; Opava, C H; Lundberg, I E; Bäck, M; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Physiotherapy

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