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Radiation-Induced Meningiomas After Childhood Brain Tumor : A Magnetic Resonance Imaging Screening Study

Remes, Tiina M. (author)
Oulu Univ Hosp, Dept Pediat & Adolescence, PEDEGO Res Unit, Med Res Ctr, POB 28, Oulu 90029, Finland;Univ Oulu, POB 28, Oulu 90029, Finland
Suo-Palosaari, Maria H. (author)
Univ Oulu, POB 28, Oulu 90029, Finland;Oulu Univ Hosp, Dept Diagnost Radiol, Oulu, Finland;Univ Oulu, Fac Med, Res Unit Med Imaging Phys & Technol, Oulu, Finland;Oulu Univ Hosp, Med Res Ctr Oulu, Oulu, Finland
Heikkilä, Vesa-Pekka (author)
Oulu Univ Hosp, Dept Oncol & Radiotherapy, Oulu, Finland
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Sutela, Anna K. (author)
Kuopio Univ Hosp, Dept Clin Radiol, Kuopio, Finland
Koskenkorva, Päivi K. T. (author)
Kuopio Univ Hosp, Dept Clin Radiol, Kuopio, Finland
Toiviainen-Salo, Sanna-Maria (author)
Univ Helsinki, HUS Med Imaging Ctr, Dept Pediat Radiol, Helsinki, Finland;Helsinki Univ Hosp, Helsinki, Finland
Porra, Liisa (author)
Helsinki Univ Hosp, Comprehens Canc Ctr, Dept Radiat Oncol, Helsinki, Finland
Arikoski, Pekka M. (author)
Kuopio Univ Hosp, Dept Pediat & Adolescence, Kuopio, Finland;Univ Eastern Finland, Kuopio, Finland
Lähteenmäki, Päivi M. (author)
Turku Univ Hosp, Dept Pediat & Adolescence, Turku, Finland;Turku Univ, Turku, Finland
Pokka, Tytti M-L (author)
Oulu Univ Hosp, Dept Pediat & Adolescence, PEDEGO Res Unit, Med Res Ctr, POB 28, Oulu 90029, Finland;Univ Oulu, POB 28, Oulu 90029, Finland
Arola, Mikko O. (author)
Tampere Univ Hosp, Dept Pediat & Adolescence, Tampere, Finland
Riikonen, V. Pekka (author)
Kuopio Univ Hosp, Dept Pediat & Adolescence, Kuopio, Finland;Univ Eastern Finland, Kuopio, Finland
Sirkiä, Kirsti H. (author)
Helsinki Univ Hosp, Dept Pediat & Adolescence, Helsinki, Finland
Lönnovist, Tuula R., I (author)
Helsinki Univ Hosp, Helsinki, Finland;Univ Helsinki, Childrens Hosp, Dept Child Neurol, Helsinki, Finland
Rantala, Heikki M. J. (author)
Oulu Univ Hosp, Dept Pediat & Adolescence, PEDEGO Res Unit, Med Res Ctr, POB 28, Oulu 90029, Finland;Univ Oulu, POB 28, Oulu 90029, Finland
Ojaniemi, Marja K. (author)
Oulu Univ Hosp, Dept Pediat & Adolescence, PEDEGO Res Unit, Med Res Ctr, POB 28, Oulu 90029, Finland;Univ Oulu, POB 28, Oulu 90029, Finland
Harila-Saari, Arja H. (author)
Uppsala universitet,Barnneurologi/Barnonkologi
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 (creator_code:org_t)
Mary Ann Liebert, 2019
2019
English.
In: Journal of Adolescent and Young Adult Oncology. - : Mary Ann Liebert. - 2156-5333 .- 2156-535X. ; 8:5, s. 593-601
Related links:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Purpose: Childhood brain tumors (CBTs) and their treatment increase the risk of secondary neoplasms (SNs). We studied the incidence of secondary craniospinal tumors with magnetic resonance imaging (MRI) screening in a national cohort of survivors of CBT treated with radiotherapy, and we analyzed the Finnish Cancer Registry (FCR) data on SNs in survivors of CBT with radiotherapy registered as a part of the primary tumor treatment. Methods: A total of 73 survivors of CBT participated in the MRI study (mean follow-up of 19 +/- 6.2 years). The incidence of SNs in a cohort of CBT patients (N = 569) was retrieved from the FCR (mean follow-up of 11 +/- 12.9 years). Brain tumors were diagnosed at age <= 16 years between the years 1970 and 2008 in the clinical study and the years 1963 and 2010 in the FCR population. Results: Secondary brain tumors, meningiomas in all and schwannoma in one, were found in 6 of the 73 (8.2%) survivors with a mean of 23 +/- 4.3 years after the diagnosis of the primary tumor. The cumulative incidence was 10.2% (95% confidence interval [CI] 3.9-25.1) in 25 years of follow-up. In the FCR data, the 25-year cumulative incidence of SNs was 2.4% (95% CI 1.3-4.1); only two brain tumors, no meningiomas, were registered. Conclusion: Survivors of CBT treated with radiotherapy have a high incidence of meningiomas, which are rarely registered in the FCR.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Keyword

secondary neoplasms
meningiomas
children
brain tumors
irradiation
survivors

Publication and Content Type

ref (subject category)
art (subject category)

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