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Programmed DNA elim...
Programmed DNA elimination of germline development genes in songbirds
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- Kinsella, Cormac M. (author)
- Uppsala universitet,Evolutionsbiologi,Science for Life Laboratory, SciLifeLab,Univ Amsterdam, Amsterdam UMC, Dept Med Microbiol, Lab Expt Virol, NL-1105 AZ Amsterdam, Netherlands
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- Ruiz-Ruano, Francisco J. (author)
- Uppsala universitet,Evolutionsbiologi,Science for Life Laboratory, SciLifeLab,Systematisk biologi,Univ Granada, Dept Genet, E-18071 Granada, Spain
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- Dion-Cote, Anne-Marie (author)
- Uppsala universitet,Evolutionsbiologi,Science for Life Laboratory, SciLifeLab,Cornell Univ, Dept Mol Biol & Genet, Ithaca, NY 14853 USA;Univ Moncton, Dept Biol, Moncton, NB E1A 3E9, Canada
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- Charles, Alexander J. (author)
- Univ Sheffield, Dept Anim & Plant Sci, Sheffield S10 2TN, S Yorkshire, England
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- Gossmann, Toni I. (author)
- Univ Sheffield, Dept Anim & Plant Sci, Sheffield S10 2TN, S Yorkshire, England;Bielefeld Univ, Dept Anim Behav, D-33501 Bielefeld, Germany
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- Cabrero, Josefa (author)
- Univ Granada, Dept Genet, E-18071 Granada, Spain
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- Kappei, Dennis (author)
- Natl Univ Singapore, Canc Sci Inst Singapore, Singapore 117599, Singapore;Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, Singapore 117596, Singapore
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- Hemmings, Nicola (author)
- Univ Sheffield, Dept Anim & Plant Sci, Sheffield S10 2TN, S Yorkshire, England
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- Simons, Mirre J. P. (author)
- Univ Sheffield, Dept Anim & Plant Sci, Sheffield S10 2TN, S Yorkshire, England
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- Camacho, Juan Pedro M. (author)
- Univ Granada, Dept Genet, E-18071 Granada, Spain
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- Forstmeier, Wolfgang (author)
- Max Planck Inst Ornithol, D-82319 Seewiesen, Germany
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- Suh, Alexander (author)
- Uppsala universitet,Evolutionsbiologi,Science for Life Laboratory, SciLifeLab,Systematisk biologi
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(creator_code:org_t)
- 2019-11-29
- 2019
- English.
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In: Nature Communications. - : NATURE PUBLISHING GROUP. - 2041-1723. ; 10
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Abstract
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- In some eukaryotes, germline and somatic genomes differ dramatically in their composition. Here we characterise a major germline-soma dissimilarity caused by a germline-restricted chromosome (GRC) in songbirds. We show that the zebra finch GRC contains >115 genes paralogous to single-copy genes on 18 autosomes and the Z chromosome, and is enriched in genes involved in female gonad development. Many genes are likely functional, evidenced by expression in testes and ovaries at the RNA and protein level. Using comparative genomics, we show that genes have been added to the GRC over millions of years of evolution, with embryonic development genes bicc1 and trim71 dating to the ancestor of songbirds and dozens of other genes added very recently. The somatic elimination of this evolutionarily dynamic chromosome in songbirds implies a unique mechanism to minimise genetic conflict between germline and soma, relevant to antagonistic pleiotropy, an evolutionary process underlying ageing and sexual traits.
Subject headings
- NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Kinsella, Cormac ...
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Ruiz-Ruano, Fran ...
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Dion-Cote, Anne- ...
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Charles, Alexand ...
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Gossmann, Toni I ...
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Cabrero, Josefa
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Kappei, Dennis
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Hemmings, Nicola
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Simons, Mirre J. ...
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Camacho, Juan Pe ...
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Forstmeier, Wolf ...
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Suh, Alexander
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Evolutionary Bio ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
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Nature Communica ...
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Uppsala University