Sökning: onr:"swepub:oai:DiVA.org:uu-404693" >
Gains of Chromosome...
-
Enblad, MalinUppsala universitet,Kolorektalkirurgi
(författare)
Gains of Chromosome 1p and 15q are Associated with Poor Survival After Cytoreductive Surgery and HIPEC for Treating Colorectal Peritoneal Metastases
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
-
2019-10-16
-
Springer Nature,2019
-
electronicrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:uu-404693
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-404693URI
-
https://doi.org/10.1245/s10434-019-07923-6DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Purpose: Genetic alterations in colorectal peritoneal metastases (PM) are largely unknown. This study was designed to analyze whole-genome copy number alterations (CNA) in colorectal PM and to identify alterations associated with prognosis after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC)Methods: All patients with PM, originating from a colorectal adenocarcinoma, who were treated with CRS and HIPEC in Uppsala Sweden, between 2004 and 2015, were included (n = 114). DNA derived from formalin-fixed paraffin-embedded (FFPE) specimens were analyzed for CNA using molecular inversion probe arrays.Results: There were extensive but varying degrees of CNA, ranging from minimal CNA to total aneuploidy. In particular, gain of parts of chromosome 1p and major parts of 15q were associated with poor survival. A combination of gains of 1p and 15q was associated with poor survival, also after adjustment for differences in peritoneal cancer index and completeness of cytoreduction score [hazard ratio (HR) 5.96; 95% confidence interval (CI) 2.19-16.18]. These patients had a mean copy number (CN) of 3.19 compared with 2.24 in patients without gains. Complete CN analysis was performed in 53 patients. Analysis was unsuccessful for the remaining patients due to insufficient amounts of DNA and signals caused by interstitial components and normal cells. There was no difference in survival between patients with successful and unsuccessful CN analysis.Conclusions: This study shows that gains of parts of chromosome 1p and of major parts of chromosome 15q were significantly associated with poor survival after CRS and HIPEC, which could represent future prognostic biomarkers.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Graf, WilhelmUppsala universitet,Kolorektalkirurgi(Swepub:uu)wilhgraf
(författare)
-
Terman, AlexeiUppsala universitet,Klinisk och experimentell patologi
(författare)
-
Pucholt, PascalUppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)paspu920
(författare)
-
Viklund, BjörnUppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinska vetenskaper(Swepub:uu)bjovi487
(författare)
-
Isaksson, AndersUppsala universitet,Institutionen för medicinska vetenskaper,Science for Life Laboratory, SciLifeLab(Swepub:uu)andeisak
(författare)
-
Birgisson, HelgiUppsala universitet,Kolorektalkirurgi(Swepub:uu)hebir255
(författare)
-
Uppsala universitetKolorektalkirurgi
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Annals of Surgical Oncology: Springer Nature26, s. 4835-48421068-92651534-4681
Internetlänk
Hitta via bibliotek
Till lärosätets databas