Sökning: onr:"swepub:oai:DiVA.org:uu-406474" > Clinical Significan...
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000 | 06058naa a2200625 4500 | |
001 | oai:DiVA.org:uu-406474 | |
003 | SwePub | |
008 | 200309s2019 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:142821465 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4064742 URI |
024 | 7 | a https://doi.org/10.1097/TP.00000000000026502 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1428214652 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Berglund, Eriku Karolinska Institutet4 aut |
245 | 1 0 | a Clinical Significance of Alloantibodies in Hand Transplantation :b A Multicenter Study |
264 | 1 | b LIPPINCOTT WILLIAMS & WILKINS,c 2019 |
338 | a print2 rdacarrier | |
520 | a Background. Donor-specific antibodies (DSAs) have a strong negative correlation with long-term survival in solid organ transplantation. Although the clinical significance of DSA and antibody-mediated rejection (AMR) in upper extremity transplantation (UET) remains to be established, a growing number of single-center reports indicate their presence and potential clinical impact. Methods. We present a multicenter study assessing the occurrence and significance of alloantibodies in UET in reference to immunological parameters and functional outcome. Results. Our study revealed a high prevalence and early development of de novo DSA and non-DSA (43%, the majority detected within the first 3 postoperative y). HLA class II mismatch correlated with antibody development, which in turn significantly correlated with the incidence of acute cellular rejection. Cellular rejections preceded antibody development in almost all cases. A strong correlation between DSA and graft survival or function cannot be statistically established at this early stage but a correlation with a lesser outcome seems to emerge. Conclusions. While the phenotype and true clinical effect of AMR remain to be better defined, the high prevalence of DSA and the correlation with acute rejection highlight the need for optimizing immunosuppression, close monitoring, and the relevance of an HLA class II match in UET recipients. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng |
700 | 1 | a Andersen Ljungdahl, Metteu Karolinska Inst, Karolinska Univ Hosp, Dept Transplantat Surg, Div Transplantat Surg,CLINTEC, Stockholm, Sweden4 aut |
700 | 1 | a Bogdanovic, Darkou Karolinska Inst, Karolinska Univ Hosp, Dept Transplantat Surg, Div Transplantat Surg,CLINTEC, Stockholm, Sweden4 aut |
700 | 1 | a Berglund, David,d 1984-u Uppsala universitet,Klinisk immunologi4 aut0 (Swepub:uu)davbe892 |
700 | 1 | a Wadstroem, Jonasu Karolinska Inst, Karolinska Univ Hosp, Dept Transplantat Surg, Div Transplantat Surg,CLINTEC, Stockholm, Sweden4 aut |
700 | 1 | a Kowalski, Janu JK Biostat AB, Stockholm, Sweden4 aut |
700 | 1 | a Brandacher, Geraldu Johns Hopkins Univ, Sch Med, Dept Plast & Reconstruct Surg, Baltimore, MD USA4 aut |
700 | 1 | a Kaminska, Dorotau Wroclaw Med Univ, Dept Nephrol & Transplantat Med, Wroclaw, Poland4 aut |
700 | 1 | a Kaufman, Christina L.u Christine M Kleinert Inst Hand & Microsurg, Louisville, KY USA4 aut |
700 | 1 | a Talbot, Simon G.u Brigham & Womens Hosp, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA4 aut |
700 | 1 | a Azari, Kodiu Univ Calif Los Angeles, David Geffen Sch Med, Dept Orthopaed Surg, Div Plast Surg, Los Angeles, CA 90095 USA4 aut |
700 | 1 | a Landin, Luisu Hosp Univ La Paz, Div Plast & Reconstruct Surg, IdiPaz, FIBHULP, Madrid, Spain4 aut |
700 | 1 | a Hoehnke, Christophu Klinikum Memmingen, Div Plast & Reconstruct Surg, Memmingen, Germany;Tech Univ Munich, Munich, Germany4 aut |
700 | 1 | a Dwyer, Karen M.u Deakin Univ, Sch Med, Fac Hlth, Geelong, Vic, Australia4 aut |
700 | 1 | a Cavadas, Pedro C.u Clin Cavadas, Plast & Reconstruct Surg Div, Valencia, Spain4 aut |
700 | 1 | a Thione, Alessandrou Clin Cavadas, Plast & Reconstruct Surg Div, Valencia, Spain4 aut |
700 | 1 | a Clarke, Brendanu Leeds Gen Infirm, Dept Plast & Reconstruct Surg, Leeds, W Yorkshire, England4 aut |
700 | 1 | a Kay, Simonu Leeds Gen Infirm, Dept Plast & Reconstruct Surg, Leeds, W Yorkshire, England4 aut |
700 | 1 | a Wilks, Danu Leeds Gen Infirm, Dept Plast & Reconstruct Surg, Leeds, W Yorkshire, England4 aut |
700 | 1 | a Iyer, Subramaniau Amrita Inst Med Sci, Plast Reconstruct Surg, Kochi, Kerala, India4 aut |
700 | 1 | a Iglesias, Martinu Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Mexico City, DF, Mexico4 aut |
700 | 1 | a Ozkan, Omeru Akdeniz Univ, Fac Med, Dept Plast & Reconstruct Surg, Antalya, Turkey4 aut |
700 | 1 | a Ozkan, Ozlenenu Akdeniz Univ, Fac Med, Dept Plast & Reconstruct Surg, Antalya, Turkey4 aut |
700 | 1 | a Krapf, Johannau Innsbruck Med Univ, Dept Plast & Reconstruct Surg, Innsbruck, Austria4 aut |
700 | 1 | a Weissenbacher, Annemarieu Med Univ Innsbruck, Ctr Operat Med, Dept Visceral Transplant & Thorac Surg, Innsbruck, Austria;Univ Oxford, Churchill Hosp, Oxford Transplant Ctr, Nuffield Dept Surg Sci, Oxford, England4 aut |
700 | 1 | a Petruzzo, Palminau Hop Edouard Herriot, HCL, Dept Transplantat, Lyon, France4 aut |
700 | 1 | a Schneeberger, Stefanu Med Univ Innsbruck, Ctr Operat Med, Dept Visceral Transplant & Thorac Surg, Innsbruck, Austria4 aut |
710 | 2 | a Karolinska Institutetb Karolinska Inst, Karolinska Univ Hosp, Dept Transplantat Surg, Div Transplantat Surg,CLINTEC, Stockholm, Sweden4 org |
773 | 0 | t Transplantationd : LIPPINCOTT WILLIAMS & WILKINSg 103:10, s. 2173-2182q 103:10<2173-2182x 0041-1337x 1534-6080 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-406474 |
856 | 4 8 | u https://doi.org/10.1097/TP.0000000000002650 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:142821465 |
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