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A meta-analysis of ...
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Öberg, Kjell,1946-Uppsala universitet,Endokrin tumörbiologi,University Hospital, Uppsala, Sweden
(author)
A meta-analysis of the accuracy of a neuroendocrine tumor mRNA genomic biomarker (NETest) in blood
- Article/chapterEnglish2020
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Elsevier,2020
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LIBRIS-ID:oai:DiVA.org:uu-407687
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-407687URI
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https://doi.org/10.1016/j.annonc.2019.11.003DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:for swepub-publicationtype
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Background: The lack of an accurate blood biomarker in neuroendocrine tumor (NET) disease has hindered management. The advance of genomic medicine and the development of molecular biomarkers has provided a strategy-liquid biopsy-to facilitate real-time management. We reviewed the role of a blood mRNA-based NET biomarker, the NETest, as an in vitro diagnostic (IVD).Patients and methods: A systematic review of the literature using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was undertaken. The methodological quality was evaluated using the QUADAS-2 tool. We identified ten original scientific papers that met the inclusion criteria. These were assessed by qualitative analysis and thereafter meta-analysis. Data were pooled and a median [95% confidence interval (CI)] diagnostic odds ratio (DOR), positive likelihood ratio (+LR), and negative likelihood ratio (-LR) were calculated. For the meta-analysis, a generic inverse variance method was undertaken using the accuracy and area under the curve (AUC) data.Results: The ten studies exhibited moderate to high methodological quality. They evaluated NETest usage both as a diagnostic and as a monitoring tool. The meta-analysis identified the diagnostic accuracy of the NETest to be 95%-96% with a mean DOR of 5 853, +LR of 195, and -LR of 0.06. The NETest was 84.5%-85.5% accurate in differentiating stable disease from progressive disease. As a marker of natural history, the accuracy was 91.5%-97.8%. As an interventional/response biomarker, the accuracy was 93.7%-97.4%. The pooled AUC for the NETest was 0.954 +/- 0.005, with a z-statistic of 175.06 (P < 0.001).Conclusions: The NETest is an accurate biomarker suitable for clinical use in NET disease management. The meta-analysis supports the utility of the NETest as an IVD to establish a diagnosis and monitor therapeutic efficacy. The use of this as a biomarker provides information relevant to NET management consistent with observations regarding utility of liquid biopsies in other oncological disciplines.
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Califano, A.Columbia Univ, Dept Syst Biol, New York, NY USA
(author)
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Strosberg, J. R.H Lee Moffitt Canc Ctr & Res Inst, Dept Gastrointestinal Oncol, Tampa, FL USA
(author)
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Ma, S.Yale Univ, Dept Biostat, New Haven, CT USA
(author)
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Pape, U.Asklepios Kliniken Hamburg, Dept Internal Med & Gastroenterol, Hamburg, Germany
(author)
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Bodei, L.Mem Sloan Kettering Canc Ctr, Dept Radiol, 1275 York Ave, New York, NY 10021 USA
(author)
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Kaltsas, G.Univ Athens, Div Endocrinol, Dept Pathophysiol, Athens, Greece
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Toumpanakis, C.UCL, Dept Gastroenterol, London, England
(author)
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Goldenring, J. R.Vanderbilt Univ, Med Ctr, Sect Surg Sci, Nashville, TN USA
(author)
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Frilling, A.Imperial Coll London, Dept Endocrine Surg, London, England
(author)
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Paulson, S.Baylor Charles A Sammons Canc Ctr, Div Med Oncol, Dallas, TX USA
(author)
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Uppsala universitetEndokrin tumörbiologi
(creator_code:org_t)
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In:Annals of Oncology: Elsevier31:2, s. 202-2120923-75341569-8041
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Öberg, Kjell, 19 ...
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Califano, A.
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Strosberg, J. R.
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Ma, S.
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Pape, U.
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Bodei, L.
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Kaltsas, G.
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Toumpanakis, C.
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Frilling, A.
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Paulson, S.
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