A meta-analysis of the accuracy of a neuroendocrine tumor mRNA genomic biomarker (NETest) in blood

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: onr:"swepub:oai:DiVA.org:uu-407687" > A meta-analysis of ...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

Öberg, Kjell,1946-Uppsala universitet,Endokrin tumörbiologi,University Hospital, Uppsala, Sweden (author)

A meta-analysis of the accuracy of a neuroendocrine tumor mRNA genomic biomarker (NETest) in blood

Article/chapterEnglish2020

Publisher, publication year, extent ...

Elsevier,2020
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:uu-407687
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-407687URI
https://doi.org/10.1016/j.annonc.2019.11.003DOI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:for swepub-publicationtype

Notes

Background: The lack of an accurate blood biomarker in neuroendocrine tumor (NET) disease has hindered management. The advance of genomic medicine and the development of molecular biomarkers has provided a strategy-liquid biopsy-to facilitate real-time management. We reviewed the role of a blood mRNA-based NET biomarker, the NETest, as an in vitro diagnostic (IVD).Patients and methods: A systematic review of the literature using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was undertaken. The methodological quality was evaluated using the QUADAS-2 tool. We identified ten original scientific papers that met the inclusion criteria. These were assessed by qualitative analysis and thereafter meta-analysis. Data were pooled and a median [95% confidence interval (CI)] diagnostic odds ratio (DOR), positive likelihood ratio (+LR), and negative likelihood ratio (-LR) were calculated. For the meta-analysis, a generic inverse variance method was undertaken using the accuracy and area under the curve (AUC) data.Results: The ten studies exhibited moderate to high methodological quality. They evaluated NETest usage both as a diagnostic and as a monitoring tool. The meta-analysis identified the diagnostic accuracy of the NETest to be 95%-96% with a mean DOR of 5 853, +LR of 195, and -LR of 0.06. The NETest was 84.5%-85.5% accurate in differentiating stable disease from progressive disease. As a marker of natural history, the accuracy was 91.5%-97.8%. As an interventional/response biomarker, the accuracy was 93.7%-97.4%. The pooled AUC for the NETest was 0.954 +/- 0.005, with a z-statistic of 175.06 (P < 0.001).Conclusions: The NETest is an accurate biomarker suitable for clinical use in NET disease management. The meta-analysis supports the utility of the NETest as an IVD to establish a diagnosis and monitor therapeutic efficacy. The use of this as a biomarker provides information relevant to NET management consistent with observations regarding utility of liquid biopsies in other oncological disciplines.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
NETest
IVD
meta-analysis
biomarker
liquid biopsy

Added entries (persons, corporate bodies, meetings, titles ...)

Califano, A.Columbia Univ, Dept Syst Biol, New York, NY USA (author)
Strosberg, J. R.H Lee Moffitt Canc Ctr & Res Inst, Dept Gastrointestinal Oncol, Tampa, FL USA (author)
Ma, S.Yale Univ, Dept Biostat, New Haven, CT USA (author)
Pape, U.Asklepios Kliniken Hamburg, Dept Internal Med & Gastroenterol, Hamburg, Germany (author)
Bodei, L.Mem Sloan Kettering Canc Ctr, Dept Radiol, 1275 York Ave, New York, NY 10021 USA (author)
Kaltsas, G.Univ Athens, Div Endocrinol, Dept Pathophysiol, Athens, Greece (author)
Toumpanakis, C.UCL, Dept Gastroenterol, London, England (author)
Goldenring, J. R.Vanderbilt Univ, Med Ctr, Sect Surg Sci, Nashville, TN USA (author)
Frilling, A.Imperial Coll London, Dept Endocrine Surg, London, England (author)
Paulson, S.Baylor Charles A Sammons Canc Ctr, Div Med Oncol, Dallas, TX USA (author)
Uppsala universitetEndokrin tumörbiologi (creator_code:org_t)

Related titles

In:Annals of Oncology: Elsevier31:2, s. 202-2120923-75341569-8041

Internet link

Find in a library

Annals of Oncology (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Öberg, Kjell, 19 ...; Califano, A.; Strosberg, J. R.; Ma, S.; Pape, U.; Bodei, L.; show more...; Kaltsas, G.; Toumpanakis, C.; Goldenring, J. R ...; Frilling, A.; Paulson, S.; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

Articles in the publication: Annals of Oncolo ...

By the university: Uppsala University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se