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Better HbA1c during the first years after diagnosis of type 1 diabetes is associated with residual C peptide 10 years later
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- Grönberg, Annika (author)
- Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa
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- Espes, Daniel, 1985- (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Transplantation och regenerativ medicin
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- Carlsson, Per-Ola (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Transplantation och regenerativ medicin
- (creator_code:org_t)
- 2020-02-26
- 2020
- English.
- In: BMJ Open Diabetes Research & Care. - : BMJ. - 2052-4897. ; 8
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Objective: To identify the factors associated with residual C peptide production at least 10 years after diagnosis in children and adolescents with type 1 diabetes.Research design and methods: 73 children and adolescents (<25 years), born in 1988-2005, diagnosed with type 1 diabetes were included during the 4-year study period (2013-2016). At least 10 years after diagnosis, we measured any remaining C peptide concentration using an ultrasensitive C peptide ELISA (>= 1.17pmol/L). The average hemoglobin A1c (HbA1c) was calculated during each of the 10 years after diagnosis and further grand average was calculated for the entire study period.Results: C peptide was detectable in 38% of participants. The C peptide concentration was 4.35.3pmol/L. At onset of type 1 diabetes, participants were on average approximately 5years of age, and their average HbA1c was 9.4% (79mmol/mol). During the first 3years after diagnosis, HbA1c was lower in the group with detectable C peptide at follow-up >= 10 years later. Moreover, detectable C peptide was more common among female participants. Body mass index SD scores had not increased since the 1-year follow-up, but were higher in patients with measurable C peptide. Nine participants (12%) had been diagnosed with celiac disease and two (3%) with hypothyreosis. Eighteen (25%) participants had retinopathy.Conclusions: Children and adolescents with detectable C peptide after more than 10 years of diabetes duration were predominantly female and had better HbA1c than others during the first 3years after diagnosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- C-peptide
- type 1
- sex differences
- celiac disease
- glycemic control
- HbA1c
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- ref (subject category)
- art (subject category)
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