Risk Factors for Graft-versus-Host Disease in Haploidentical Hematopoietic Cell Transplantation Using Post-Transplant Cyclophosphamide

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Fältnamn	Indikatorer	Metadata
000		12124naa a2201165 4500
001		oai:DiVA.org:uu-419189
003		SwePub
008		200914s2020 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:144217400
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4191892 URI
024	7	a https://doi.org/10.1016/j.bbmt.2020.05.0012 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1442174002 URI
040		a (SwePub)uud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Im, Annieu Univ Pittsburgh, UPMC, Hillman Canc Ctr, Pittsburgh, PA USA.4 aut
245	1 0	a Risk Factors for Graft-versus-Host Disease in Haploidentical Hematopoietic Cell Transplantation Using Post-Transplant Cyclophosphamide
264	1	b Elsevier BV,c 2020
338		a print2 rdacarrier
520		a Post-transplant cyclophosphamide (PTCy) has significantly increased the successful use of haploidentical donors with a relatively low incidence of graft-versus-host disease (GVHD). Given its increasing use, we sought to determine risk factors for GVHD after haploidentical hematopoietic cell transplantation (haplo-HCT) using PTCy. Data from the Center for International Blood and Marrow Transplant Research on adult patients with acute myeloid leukemia, acute lymphoblastic leukemia, myelodysplastic syndrome, or chronic myeloid leukemia who underwent PTCy-based haplo-HCT (2013 to 2016) were analyzed and categorized into 4 groups based on myeloablative (MA) or reduced-intensity conditioning (RIC) and bone marrow (BM) or peripheral blood (PB) graft source. In total, 646 patients were identified (MA-BM = 79, MA-PB = 183, RIC-BM = 192, RIC-PB = 192). The incidence of grade 2 to 4 acute GVHD at 6 months was highest in MA-PB (44%), followed by RIC-PB (36%), MA-BM (36%), and RIC-BM (30%) (P = .002). The incidence of chronic GVHD at 1 year was 40%, 34%, 24%, and 20%, respectively (P < .001). In multivariable analysis, there was no impact of stem cell source or conditioning regimen on grade 2 to 4 acute GVHD; however, older donor age (30 to 49 versus <29 years) was significantly associated with higher rates of grade 2 to 4 acute GVHD (hazard ratio [HR], 1.53; 95% confidence interval [CI], 1.11 to 2.12; P = .01). In contrast, PB compared to BM as a stem cell source was a significant risk factor for the development of chronic GVHD (HR, 1.70; 95% CI, 1.11 to 2.62; P = .01) in the RIC setting. There were no differences in relapse or overall survival between groups. Donor age and graft source are risk factors for acute and chronic GVHD, respectively, after PTCy-based haplo-HCT. Our results indicate that in RIC haplo-HCT, the risk of chronic GVHD is higher with PB stem cells, without any difference in relapse or overall survival.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Hematologi0 (SwePub)302022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Hematology0 (SwePub)302022 hsv//eng
700	1	a Rashidi, Arminu Univ Minnesota, Dept Med, Div Hematol Oncol & Transplantat, Box 736 UMHC, Minneapolis, MN 55455 USA.4 aut
700	1	a Wang, Taou Med Coll Wisconsin, Dept Med, CIBMTR, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Equ, Div Biostat, Milwaukee, WI 53226 USA.4 aut
700	1	a Hemmer, Michaelu Med Coll Wisconsin, Dept Med, CIBMTR, Milwaukee, WI 53226 USA.4 aut
700	1	a MacMillan, Margaret L.u Univ Minnesota, Dept Pediat, Blood & Marrow Transplant Program, Minneapolis, MN 55455 USA.4 aut
700	1	a Pidala, Josephu H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA.4 aut
700	1	a Jagasia, Madanu Vanderbilt Univ, Med Ctr, Nashville, TN USA.4 aut
700	1	a Pavletic, Stevenu NCI, Immune Deficiency Cellular Therapy Program, Ctr Canc Res, Bethesda, MD 20892 USA.4 aut
700	1	a Majhail, Navneet S.u Cleveland Clin, Taussig Canc Inst, Blood & Marrow Transplant Program, 9500 Euclid Ave,CA 60, Cleveland, OH 44195 USA.4 aut
700	1	a Weisdorf, Danielu Univ Minnesota, Dept Med, Div Hematol Oncol & Transplantat, Box 736 UMHC, Minneapolis, MN 55455 USA.4 aut
700	1	a Abdel-Azim, Hishamu Univ Southern Calif, Div Hematol Oncol & Blood & Marrow Transplantat, Childrens Hosp Los Angeles, Keck Sch Med, Los Angeles, CA 90007 USA.4 aut
700	1	a Agrawal, Vaibhavu Indiana Univ Sch Med, Div Hematol Oncol, Indianapolis, IN 46202 USA.4 aut
700	1	a Al-Homsi, A. Sameru NYU, Langone Med Ctr, New York, NY USA.4 aut
700	1	a Aljurf, Mahmoudu King Faisal Specialist Hosp Ctr & Res, Dept Oncol, Riyadh, Saudi Arabia.4 aut
700	1	a Askar, Medhatu Baylor Univ, Med Ctr, Dept Pathol & Lab Med, Dallas, TX USA.4 aut
700	1	a Auletta, Jeffery J.u Nationwide Childrens Hosp, Blood & Marrow Transplant Program, Columbus, OH USA.;Nationwide Childrens Hosp, Host Def Program, Div Hematol, Columbus, OH USA.;Nationwide Childrens Hosp, Div Oncol, Host Def Program, Columbus, OH USA.;Nationwide Childrens Hosp, Div Bone Marrow Transplant, Host Def Program, Columbus, OH USA.;Nationwide Childrens Hosp, Div Infect Dis, Host Def Program, Columbus, OH USA.4 aut
700	1	a Bashey, Asadu Northside Hosp, Blood & Marrow Transplant Program, Atlanta, GA USA.4 aut
700	1	a Beitinjaneh, Ameru Univ Miami, Dept Hematol & Oncol, Miami, FL USA.4 aut
700	1	a Bhatt, Vijaya Raju Univ Nebraska Med Ctr, Fred & Pamela Buffett Canc Ctr, Omaha, NE USA.4 aut
700	1	a Byrne, Michaelu Vanderbilt Univ, Med Ctr, Nashville, TN USA.4 aut
700	1	a Cahn, Jean-Yvesu CHU Grenoble Alpes, Dept Hematol, Grenoble, France.4 aut
700	1	a Cairo, Mitchellu New York Med Coll, Dept Pediat, Div Pediat Hematol Oncol & Stem Cell Transplantat, Valhalla, NY 10595 USA.4 aut
700	1	a Castillo, Paulu UF Hlth Shands Childrens Hosp, Gainesville, FL USA.4 aut
700	1	a Cerny, Janu Univ Massachusetts, Med Ctr, Dept Med, Div Hematol Oncol, Worcester, MA USA.4 aut
700	1	a Chhabra, Saurabhu Med Coll Wisconsin, Dept Med, CIBMTR, Milwaukee, WI 53226 USA.4 aut
700	1	a Choe, Hannahu Ohio State Univ, Wexner Med Ctr, James Comprehens Canc Ctr, Columbus, OH 43210 USA.4 aut
700	1	a Ciurea, Stefanu Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.4 aut
700	1	a Daly, Andrewu Tom Baker Canc Clin, Calgary, AB, Canada.4 aut
700	1	a Diaz Perez, Miguel Angelu Hosp Infantil Univ Nino Jesus, Dept Hematol Oncol, Madrid, Spain.4 aut
700	1	a Farhadfar, Noshau Univ Florida, Coll Med, Div Hematol Oncol, Gainesville, FL USA.4 aut
700	1	a Gadalla, Shahinaz M.u NCI, Div Canc Epidemiol & Genet, NIH, Clin Genet Branch, Rockville, MD USA.4 aut
700	1	a Gale, Robertu Imperial Coll London, Hematol Res Ctr, Dept Med, Div Expt Med, London, England.4 aut
700	1	a Ganguly, Siddharthau Univ Kansas Hlth Syst, Div Hematol Malignancy & Cellular Therapeut, Kansas City, KS USA.4 aut
700	1	a Gergis, Usamau Thomas Jefferson Univ, Dept Med Oncol, Philadelphia, PA USA.4 aut
700	1	a Hanna, Rabiu Cleveland Clin Fdn, 9500 Euclid Ave, Cleveland, OH 44195 USA.4 aut
700	1	a Hematti, Peimanu Univ Wisconsin, Dept Med, Div Hematol Oncol Bone Marrow Transplantat, Madison, WI USA.4 aut
700	1	a Herzig, Rogeru Univ Kentucky, Chandler Med Ctr, Louisville, KY USA.4 aut
700	1	a Hildebrandt, Gerhard C.u Univ Kentucky, Markey Canc Ctr, Lexington, KY USA.4 aut
700	1	a Lad, Deepesh P.u Postgrad Inst Med Educ & Res, Dept Internal Med, Chandigarh, India.4 aut
700	1	a Lee, Catherineu Univ Utah, Huntsman Canc Inst, Utah Blood & Marrow Transplant Program, Salt Lake City, UT USA.4 aut
700	1	a Lehmann, Leslieu Boston Childrens Hosp, Dana Farber Canc Inst, Boston, MA USA.4 aut
700	1	a Lekakis, Lazarosu Univ Miami, Dept Hematol & Oncol, Miami, FL USA.4 aut
700	1	a Kamble, Rammurti T.u Baylor Coll Med, Ctr Cell & Gene Therapy, Div Hematol & Oncol, Houston, TX 77030 USA.4 aut
700	1	a Kharfan-Dabaja, Mohamed A.u Mayo Clin, Div Hematol Oncol, Blood & Marrow Transplantat Program, Jacksonville, FL USA.4 aut
700	1	a Khandelwal, Poojau Cincinnati Childrens Hosp Med Ctr, Div Bone Marrow Transplant & Immune Deficiency, Cincinnati, OH 45229 USA.;Univ Cincinnati, Dept Pediat, Cincinnati, OH USA.4 aut
700	1	a Martino, Rodrigou Hosp Santa Creu & Sant Pau, Div Clin Hematol, Barcelona, Spain.4 aut
700	1	a Murthy, Hemant S.u Mayo Clin, Div Hematol Oncol, Blood & Marrow Transplantat Program, Jacksonville, FL USA.4 aut
700	1	a Nishihori, Taigau H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplant & Cellular Immunot, Tampa, FL USA.4 aut
700	1	a O'Brien, Tracey A.u Sydney Childrens Hosp, Kids Canc Ctr, Blood & Marrow Transplant Program, Sydney, NSW, Australia.4 aut
700	1	a Olsson, Richardu Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Stockholm, Sweden.4 aut0 (Swepub:uu)riols677
700	1	a Patel, Sagar S.u Univ Utah, Blood & Marrow Transplant Program, Salt Lake City, UT USA.4 aut
700	1	a Perales, Miguel-Angelu Mem Sloan Kettering Canc Ctr, Dept Med, Adult Bone Marrow Transplant Serv, 1275 York Ave, New York, NY 10021 USA.4 aut
700	1	a Prestidge, Timu Starship Childrens Hosp, Blood & Canc Ctr, Auckland, New Zealand.4 aut
700	1	a Qayed, Munau Emory Univ, Sch Med, Dept Pediat, Atlanta, GA USA.4 aut
700	1	a Romee, Rizwanu Dana Farber Canc Inst, Boston, MA 02115 USA.4 aut
700	1	a Schoemans, Heleneu Univ Hosp Leuven, Dept Hematol, Leuven, Belgium.;Katholieke Univ Leuven, Leuven, Belgium.4 aut
700	1	a Seo, Sachikou Dokkyo Med Univ, Dept Hematol & Oncol, Mibu, Tochigi, Japan.4 aut
700	1	a Sharma, Akshayu St Jude Childrens Res Hosp, Dept Bone Marrow Transplantat & Cellular Therapy, 332 N Lauderdale St, Memphis, TN 38105 USA.4 aut
700	1	a Solh, Melhemu Northside Hosp, Blood & Marrow Transplant Grp Georgia, Atlanta, GA USA.4 aut
700	1	a Strair, Rogeru Rutgers State Univ, Rutgers Canc Inst New Jersey, Brunswick, NJ USA.4 aut
700	1	a Teshima, Takanoriu Hokkaido Univ Hosp, Sapporo, Hokkaido, Japan.4 aut
700	1	a Urbano-Ispizua, Alvarou Univ Barcelona, Hosp Clin, IDIBAPS, Dept Hematol, Barcelona, Spain.;Inst Res Josep Carreras, Barcelona, Spain.4 aut
700	1	a Van der Poel, Marjoleinu Maastricht Univ, Med Ctr, Maastricht, Netherlands.4 aut
700	1	a Vij, Raviu Washington Univ, Sch Med, Div Hematol & Oncol, St Louis, MO USA.4 aut
700	1	a Wagner, John L.u Thomas Jefferson Univ, Dept Med Oncol, Philadelphia, PA USA.4 aut
700	1	a William, Basemu Ohio State Univ, Div Hematol, Columbus, OH 43210 USA.4 aut
700	1	a Wirk, Baldeepu Penn State Canc Inst, Bone Marrow Transplant Program, Hershey, PA USA.4 aut
700	1	a Yared, Jean A.u Univ Maryland, Dept Med, Greenebaum Comprehens Canc Ctr, Blood & Marrow Transplantat Program,Div Hematol O, Baltimore, MD 21201 USA.4 aut
700	1	a Spellman, Steve R.u Med Coll Wisconsin, Dept Med, CIBMTR, Milwaukee, WI 53226 USA.4 aut
700	1	a Arora, Muktau Univ Minnesota, Dept Med, Div Hematol Oncol & Transplantat, Box 736 UMHC, Minneapolis, MN 55455 USA.4 aut
700	1	a Hamilton, Betty K.u Cleveland Clin, Taussig Canc Inst, Blood & Marrow Transplant Program, 9500 Euclid Ave,CA 60, Cleveland, OH 44195 USA.4 aut
710	2	a Univ Pittsburgh, UPMC, Hillman Canc Ctr, Pittsburgh, PA USA.b Univ Minnesota, Dept Med, Div Hematol Oncol & Transplantat, Box 736 UMHC, Minneapolis, MN 55455 USA.4 org
773	0	t Biology of blood and marrow transplantationd : Elsevier BVg 26:8, s. 1459-1468q 26:8<1459-1468x 1083-8791x 1523-6536
856	4	u http://www.astctjournal.org/article/S108387912030286X/pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-419189
856	4 8	u https://doi.org/10.1016/j.bbmt.2020.05.001
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:144217400

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Av författaren/redakt...: Im, Annie; Rashidi, Armin; Wang, Tao; Hemmer, Michael; MacMillan, Marga ...; Pidala, Joseph; visa fler...; Jagasia, Madan; Pavletic, Steven; Majhail, Navneet ...; Weisdorf, Daniel; Abdel-Azim, Hish ...; Agrawal, Vaibhav; Al-Homsi, A. Sam ...; Aljurf, Mahmoud; Askar, Medhat; Auletta, Jeffery ...; Bashey, Asad; Beitinjaneh, Ame ...; Bhatt, Vijaya Ra ...; Byrne, Michael; Cahn, Jean-Yves; Cairo, Mitchell; Castillo, Paul; Cerny, Jan; Chhabra, Saurabh; Choe, Hannah; Ciurea, Stefan; Daly, Andrew; Diaz Perez, Migu ...; Farhadfar, Nosha; Gadalla, Shahina ...; Gale, Robert; Ganguly, Siddhar ...; Gergis, Usama; Hanna, Rabi; Hematti, Peiman; Herzig, Roger; Hildebrandt, Ger ...; Lad, Deepesh P.; Lee, Catherine; Lehmann, Leslie; Lekakis, Lazaros; Kamble, Rammurti ...; Kharfan-Dabaja, ...; Khandelwal, Pooj ...; Martino, Rodrigo; Murthy, Hemant S ...; Nishihori, Taiga; O'Brien, Tracey ...; Olsson, Richard; Patel, Sagar S.; Perales, Miguel- ...; Prestidge, Tim; Qayed, Muna; Romee, Rizwan; Schoemans, Helen ...; Seo, Sachiko; Sharma, Akshay; Solh, Melhem; Strair, Roger; Teshima, Takanor ...; Urbano-Ispizua, ...; Van der Poel, Ma ...; Vij, Ravi; Wagner, John L.; William, Basem; Wirk, Baldeep; Yared, Jean A.; Spellman, Steve ...; Arora, Mukta; Hamilton, Betty ...; visa färre...

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