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A Single Shot Pre-fusion-Stabilized Bovine RSV F Vaccine is Safe and Effective in Newborn Calves with Maternally Derived Antibodies

Riffault, Sabine (author)
Univ Paris Saclay, INRAE, UVSQ, VIM, F-78350 Jouy En Josas, France.
Hägglund, Sara (author)
Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences,Swedish Univ Agr Sci, Dept Clin Sci, Unit Ruminant Med, Host Pathogen Interact Grp, Box 7054, S-75007 Uppsala, Sweden.
Guzman, Efrain (author)
Pirbright Inst, Ash Rd, Woking GU24 0NF, Surrey, England.
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Naslund, Katarina (author)
Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences,Swedish Univ Agr Sci, Dept Clin Sci, Unit Ruminant Med, Host Pathogen Interact Grp, Box 7054, S-75007 Uppsala, Sweden.
Jouneau, Luc (author)
Univ Paris Saclay, INRAE, UVSQ, VIM, F-78350 Jouy En Josas, France.
Dubuquoy, Catherine (author)
Univ Paris Saclay, INRAE, UVSQ, VIM, F-78350 Jouy En Josas, France.
Pietralunga, Vincent (author)
Univ Paris Saclay, INRAE, UVSQ, VIM, F-78350 Jouy En Josas, France.
Laubreton, Daphne (author)
Univ Paris Saclay, INRAE, UVSQ, VIM, F-78350 Jouy En Josas, France.
Boulesteix, Olivier (author)
INRAE, PFIE, F-37380 Nouzilly, France.
Gauthier, David (author)
INRAE, PFIE, F-37380 Nouzilly, France.
Remot, Aude (author)
Univ Tours, ISP, INRAE, F-37380 Nouzilly, France.
Boukaridi, Abdelhak (author)
Univ Paris Saclay, INRAE, AgroParisTech, GABI, F-78350 Jouy En Josas, France.
Falk, Alexander, Research engineer, 1986- (author)
Uppsala universitet,Analytisk kemi
Shevchenko, Ganna (author)
Uppsala universitet,Analytisk kemi
Lind, Sara Bergstrom (author)
Uppsala universitet,Analytisk kemi
Vargmar, Karin (author)
Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health,Swedish Univ Agr Sci, Dept Biomed & Vet Publ Hlth, Box 7054, S-875007 Uppsala, Sweden.
Zhang, Baoshan (author)
NIAID, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
Kwong, Peter D. (author)
NIAID, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
Rodriguez, Maria Jose (author)
Appl Immunol & Genet SL INGENASA, Madrid 28037, Spain.
Duran, Marga Garcia (author)
Appl Immunol & Genet SL INGENASA, Madrid 28037, Spain.
Schwartz-Cornil, Isabelle (author)
Univ Paris Saclay, INRAE, UVSQ, VIM, F-78350 Jouy En Josas, France.
Eleouet, Jean-Francois (author)
Univ Paris Saclay, INRAE, UVSQ, VIM, F-78350 Jouy En Josas, France.
Taylor, Geraldine (author)
Pirbright Inst, Ash Rd, Woking GU24 0NF, Surrey, England.
Valarcher, Jean Francois (author)
Swedish Univ Agr Sci, Dept Clin Sci, Unit Ruminant Med, Host Pathogen Interact Grp, Box 7054, S-75007 Uppsala, Sweden.
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Univ Paris Saclay, INRAE, UVSQ, VIM, F-78350 Jouy En Josas, France Institutionen för kliniska vetenskaper (KV) (creator_code:org_t)
 
2020-05-18
2020
English.
In: Vaccines. - : MDPI. - 2076-393X. ; 8:2
Related links:
https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
https://www.mdpi.com...
https://urn.kb.se/re...
https://doi.org/10.3...
https://res.slu.se/i...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Achieving safe and protective vaccination against respiratory syncytial virus (RSV) in infants and in calves has proven a challenging task. The design of recombinant antigens with a conformation close to their native form in virus particles is a major breakthrough. We compared two subunit vaccines, the bovine RSV (BRSV) pre-fusion F (preF) alone or with nanorings formed by the RSV nucleoprotein (preF+N). PreF and N proteins are potent antigenic targets for neutralizing antibodies and T cell responses, respectively. To tackle the challenges of neonatal immunization, three groups of six one-month-old calves with maternally derived serum antibodies (MDA) to BRSV received a single intramuscular injection of PreF, preF+N with Montanide (TM) ISA61 VG (ISA61) as adjuvant or only ISA61 (control). One month later, all calves were challenged with BRSV and monitored for virus replication in the upper respiratory tract and for clinical signs of disease over one week, and then post-mortem examinations of their lungs were performed. Both preF and preF+N vaccines afforded safe, clinical, and virological protection against BRSV, with little difference between the two subunit vaccines. Analysis of immune parameters pointed to neutralizing antibodies and antibodies to preF as being significant correlates of protection. Thus, a single shot vaccination with preF appears sufficient to reduce the burden of BRSV disease in calves with MDA.

Subject headings

NATURVETENSKAP  -- Biologi -- Immunologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Immunology (hsv//eng)
LANTBRUKSVETENSKAPER  -- Veterinärmedicin -- Klinisk vetenskap (hsv//swe)
AGRICULTURAL SCIENCES  -- Veterinary Science -- Clinical Science (hsv//eng)

Keyword

bovine
neonate
pre-fusion conformation
respiratory syncytial virus
subunit vaccine

Publication and Content Type

ref (subject category)
art (subject category)

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