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Seizures during tre...
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Anastasopoulou, StavroulaKarolinska Institutet
(author)
Seizures during treatment of childhood acute lymphoblastic leukemia : A population-based cohort study
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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ELSEVIER SCI LTD,2020
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-420823
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-420823URI
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https://doi.org/10.1016/j.ejpn.2020.04.004DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:144411196URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background: Seizures are common in children with acute lymphoblastic leukemia (ALL). As ALL survival rates are improving, the challenge to minimize treatment related side effects and late sequelae rises. Here, we studied the frequency, timing, etiology and risk factors of seizures in ALL patients. Methods: The study included children aged 1-17.9 years at diagnosis of B-cell-precursor and T cell ALL who were treated according to the Nordic Society of Pediatric Hematology and Oncology (NOPHO) ALL2008 protocol between 2008 and 2015. Detailed patient data were acquired from the NOPHO ALL2008 registry and by review of medical records. Results: Seizures occurred in 81/1464 (5.5%) patients. The cumulative incidence of seizures at one months was 1.7% (95% CI: 1.2-2.5) and at one year 5.3% (95% CI 4.2-6.5%). Patients aged 10-17.9 years, those with T cell immunophenotype, CNS involvement, or high-risk induction with dexamethasone had higher risk for seizures in univariable analyses. Only age remained a risk factor in multivariable analyses (the cumulative incidence of seizures for patients 10-17.9 years old at one year was 9.0% (95% CI: 6.2-12.9)). Of the 81 patients with seizures, 43 had posterior reversible encephalopathy syndrome (PRES), 15 had isolated seizures, nine had sinus venous thrombosis (SVT), three had stroke-like syndrome, and 11 had other neurotoxicities. Epilepsy diagnosis was reported in totally 11 ALL survivors at last follow up. Conclusion: Seizures are relatively common in ALL patients and occur most often in patients with PRES, SVT, or as an isolated symptom. Older children have higher risk of seizures. (C) 2020 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
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Heyman, MatsKarolinska Institutet
(author)
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Eriksson, Mats A.Karolinska Institutet
(author)
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Niinimaki, RiittaOulu Univ Hosp, Dept Children & Adolescents, Oulu, Finland.;Univ Oulu, PEDEGO Res Unit, Oulu, Finland.
(author)
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Taskinen, MerviHelsinki Univ Hosp, Div Pediat Hematol & Oncol & Stem Cell Transplant, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.
(author)
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Mikkel, SirjeUniv Tartu, Dept Hematol & Oncol, Tartu, Estonia.
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Vaitkeviciene, Goda E.Vilnius Univ Hosp Santaros Klin, Childrens Hosp, Vilnius, Lithuania.;Vilnius Univ, Vilnius, Lithuania.
(author)
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Johannsdottir, Inga MariaOslo Univ Hosp, Dept Pediat Hematol Oncol, Oslo, Norway.
(author)
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Myrberg, Ida HedKarolinska Institutet
(author)
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Jonsson, Olafur GisliUniv Iceland, Dept Pediat, Reykjavik, Iceland.
(author)
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Als-Nielsen, BodilUniv Copenhagen, Rigshosp, Dept Paediat & Adolescent Med, Copenhagen, Denmark.
(author)
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Schmiegelow, KjeldUniv Copenhagen, Rigshosp, Dept Paediat & Adolescent Med, Copenhagen, Denmark.;Univ Copenhagen, Fac Med, Inst Clin Med, Copenhagen, Denmark.
(author)
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Banerjee, JoannaHelsinki Univ Hosp, Div Pediat Hematol & Oncol & Stem Cell Transplant, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.
(author)
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Ranta, SusannaKarolinska Institutet
(author)
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Harila-Saari, Arja H.Uppsala universitet,Barnneurologi/Barnonkologi(Swepub:uu)arjha456
(author)
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Karolinska InstitutetOulu Univ Hosp, Dept Children & Adolescents, Oulu, Finland.;Univ Oulu, PEDEGO Res Unit, Oulu, Finland.
(creator_code:org_t)
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In:European journal of paediatric neurology: ELSEVIER SCI LTD27, s. 72-771090-37981532-2130
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