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Incidence, Risk Fac...
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Epperla, NarendranathOhio State Univ, James Canc Hosp, Dept Med, Div Hematol, Columbus, OH 43210 USA.;Ohio State Univ, Solove Res Inst, Columbus, OH 43210 USA.
(författare)
Incidence, Risk Factors for and Outcomes of Transplant-Associated Thrombotic Microangiopathy
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
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2020-03-02
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WILEY,2020
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-423869
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-423869URI
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https://doi.org/10.1111/bjh.16457DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:143409431URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Transplant-associated thrombotic microangiopathy (TA-TMA) is a complication of allogeneic transplantation (allo-HCT). The incidence and risk factors associated with TA-TMA are not well known. A retrospective analysis from the Center for International Blood and Marrow Transplant Research (CIBMTR) was conducted including patients receiving allo-HCT between 2008 and 2016, with the primary objective of evaluating the incidence of TA-TMA. Secondary objectives included identification of risk factors associated with TA-TMA, and the impact of TA-TMA on overall survival and the need for renal replacement therapy (RRT). Among 23,665 allo-HCT recipients, the 3-year cumulative incidence of TA-TMA was 3%. Variables independently-associated with increased incidence of TA-TMA included female sex, prior autologous transplant, primary disease (acute lymphoblastic leukaemia and severe aplastic anaemia), donor type (mismatched or unrelated donor), conditioning intensity (myeloablative), GVHD prophylaxis (sirolimus + calcineurin inhibitor), pre-transplant kidney dysfunction and acute GVHD (time-varying effect). TA-TMA was associated with higher mortality (HR = 3 center dot 1, 95% Confidence Interval [CI] = 2 center dot 8-16 center dot 3) and RRT requirement (HR = 7 center dot 1, 95% CI = 5 center dot 7-311 center dot 6). This study provides epidemiologic data on TA-TMA and its impact on transplant outcomes. Increased awareness of the risk factors will enable providers to be vigilant of this uncommon but serious transplant complication. The results will also provide benchmarking for future study designs and comparisons.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Li, AngUniv Washington, Seattle, WA 98195 USA.
(författare)
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Logan, BrentMed Coll Wisconsin, CIBMTR, Dept Med, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Equ, Div Biostat, Milwaukee, WI 53226 USA.
(författare)
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Fretham, CaitrinBe The Match, Natl Marrow Donor Program, CIBMTR, Minneapolis, MN USA.
(författare)
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Chhabra, SaurabhMed Coll Wisconsin, CIBMTR, Dept Med, Milwaukee, WI 53226 USA.
(författare)
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Aljurf, MahmoudKing Faisal Specialist Hosp Ctr & Res, Dept Oncol, Riyadh, Saudi Arabia.
(författare)
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Chee, LynetteRoyal Melbourne Hosp City Campus, Victoria, Australia.
(författare)
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Copelan, EdwardAtrium Hlth, Carolinas HealthCare Syst, Levine Canc Inst, Charlotte, NC USA.
(författare)
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Freytes, Cesar O.Texas Transplant Inst, San Antonio, TX USA.
(författare)
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Hematti, PeimanUniv Wisconsin, Dept Med, Div Hematol Oncol Bone Marrow Transplantat, Madison, WI USA.
(författare)
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Lazarus, Hillard M.Case Western Reserve Univ, Cleveland, OH 44106 USA.
(författare)
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Litzow, MarkMayo Clin Rochester, Div Hematol, Rochester, MN USA.;Mayo Clin Rochester, Transplant Ctr, Rochester, MN USA.
(författare)
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Nishihori, TaigaH Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplant & Cellular Immunot, Tampa, FL USA.
(författare)
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Olsson, RichardKarolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Stockholm, Sweden.(Swepub:uu)riols677
(författare)
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Prestidge, TimStarship Childrens Hosp, Blood & Canc Ctr, Auckland, New Zealand.
(författare)
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Saber, WaelMed Coll Wisconsin, CIBMTR, Dept Med, Milwaukee, WI 53226 USA.
(författare)
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Wirk, BaldeepSeattle Canc Care Alliance, Div Bone Marrow Transplant, Seattle, WA USA.
(författare)
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Yared, Jean A.Univ Maryland, Greenebaum Comprehens Canc Ctr, Div Hematol Oncol, Dept Med,Blood & Marrow Transplantat Program, Baltimore, MD 21201 USA.
(författare)
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Loren, AlisonUniv Penn, Perelman Sch Med, Dept Med, Div Hematol Oncol, Philadelphia, PA 19104 USA.
(författare)
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Pasquini, MarceloMed Coll Wisconsin, CIBMTR, Dept Med, Milwaukee, WI 53226 USA.
(författare)
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Ohio State Univ, James Canc Hosp, Dept Med, Div Hematol, Columbus, OH 43210 USA.;Ohio State Univ, Solove Res Inst, Columbus, OH 43210 USA.Univ Washington, Seattle, WA 98195 USA.
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:British Journal of Haematology: WILEY189:6, s. 1171-11810007-10481365-2141
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Till lärosätets databas
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Epperla, Narendr ...
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Li, Ang
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Logan, Brent
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Fretham, Caitrin
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Chhabra, Saurabh
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Aljurf, Mahmoud
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visa fler...
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Chee, Lynette
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Copelan, Edward
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Freytes, Cesar O ...
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Hematti, Peiman
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Lazarus, Hillard ...
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Litzow, Mark
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Nishihori, Taiga
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Olsson, Richard
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Prestidge, Tim
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Saber, Wael
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Wirk, Baldeep
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Yared, Jean A.
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Loren, Alison
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Pasquini, Marcel ...
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visa färre...
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Uppsala universitet
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