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Age-Dependency of N...
Age-Dependency of Neurite Outgrowth in Postnatal Mouse Cochlear Spiral Ganglion Explants
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- Frick, Claudia (författare)
- Univ Tubingen, Dept Otolaryngol Head & Neck Surg, Tubingen Hearing Res Ctr, Med Ctr, D-72076 Tubingen, Germany.;Max Planck Inst Dev Biol, Dept Microbiome Sci, D-72076 Tubingen, Germany.
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- Fink, Stefan (författare)
- Univ Tubingen, Dept Otolaryngol Head & Neck Surg, Tubingen Hearing Res Ctr, Med Ctr, D-72076 Tubingen, Germany.
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- Schmidbauer, Dominik (författare)
- Med Univ Innsbruck, Inner Ear Lab Innsbruck, A-6020 Innsbruck, Austria.
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- Rousset, Francis (författare)
- Univ Geneva, Fac Med, Dept Clin Neurosci, Inner Ear & Olfact Lab, CH-1206 Geneva, Switzerland.
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- Eickhoff, Holger (författare)
- EMC Microcollect GmbH, D-72070 Tubingen, Germany.
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- Tropitzsch, Anke (författare)
- Univ Tubingen, Dept Otolaryngol Head & Neck Surg, Tubingen Hearing Res Ctr, Med Ctr, D-72076 Tubingen, Germany.
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- Kramer, Benedikt (författare)
- Univ Tubingen, Dept Otolaryngol Head & Neck Surg, Tubingen Hearing Res Ctr, Med Ctr, D-72076 Tubingen, Germany.;Univ Hosp Mannheim, Dept Otolaryngol Head & Neck Surg, D-68167 Mannheim, Germany.
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- Senn, Pascal (författare)
- Univ Geneva, Fac Med, Dept Clin Neurosci, Inner Ear & Olfact Lab, CH-1206 Geneva, Switzerland.
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- Glueckert, Rudolf (författare)
- Med Univ Innsbruck, Inner Ear Lab Innsbruck, A-6020 Innsbruck, Austria.;Univ Clin Otolaryngol, Tirol Kliniken Innsbruck, A-6020 Innsbruck, Austria.
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- Rask-Andersen, Helge (författare)
- Uppsala universitet,Öron-, näs- och halssjukdomar
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- Wiesmüller, Karl-Heinz (författare)
- EMC Microcollect GmbH, D-72070 Tubingen, Germany.
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- Löwenheim, Hubert (författare)
- Univ Tubingen, Dept Otolaryngol Head & Neck Surg, Tubingen Hearing Res Ctr, Med Ctr, D-72076 Tubingen, Germany.
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- Müller, Marcus (författare)
- Univ Tubingen, Dept Otolaryngol Head & Neck Surg, Tubingen Hearing Res Ctr, Med Ctr, D-72076 Tubingen, Germany.
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Univ Tubingen, Dept Otolaryngol Head & Neck Surg, Tubingen Hearing Res Ctr, Med Ctr, D-72076 Tubingen, Germany;Max Planck Inst Dev Biol, Dept Microbiome Sci, D-72076 Tubingen, Germany. Univ Tubingen, Dept Otolaryngol Head & Neck Surg, Tubingen Hearing Res Ctr, Med Ctr, D-72076 Tubingen, Germany. (creator_code:org_t)
- 2020-08-21
- 2020
- Engelska.
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Ingår i: Brain Sciences. - : MDPI. - 2076-3425. ; 10:9
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Background: The spatial gap between cochlear implants (CIs) and the auditory nerve limits frequency selectivity as large populations of spiral ganglion neurons (SGNs) are electrically stimulated synchronously. To improve CI performance, a possible strategy is to promote neurite outgrowth toward the CI, thereby allowing a discrete stimulation of small SGN subpopulations. Brain-derived neurotrophic factor (BDNF) is effective to stimulate neurite outgrowth from SGNs.Method: TrkB (tropomyosin receptor kinase B) agonists, BDNF, and five known small-molecule BDNF mimetics were tested for their efficacy in stimulating neurite outgrowth in postnatal SGN explants. To modulate Trk receptor-mediated effects, TrkB and TrkC ligands were scavenged by an excess of recombinant receptor proteins. The pan-Trk inhibitor K252a was used to block Trk receptor actions.Results: THF (7,8,3 '-trihydroxyflavone) partly reproduced the BDNF effect in postnatal day 7 (P7) mouse cochlear spiral ganglion explants (SGEs), but failed to show effectiveness in P4 SGEs. During the same postnatal period, spontaneous and BDNF-stimulated neurite outgrowth increased. The increased neurite outgrowth in P7 SGEs was not caused by the TrkB/TrkC ligands, BDNF and neurotrophin-3 (NT-3).Conclusions: The age-dependency of induction of neurite outgrowth in SGEs was very likely dependent on presently unidentified factors and/or molecular mechanisms which may also be decisive for the age-dependent efficacy of the small-molecule TrkB receptor agonist THF.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- small-molecule BDNF mimetics
- THF
- NT-3
- Trk receptors
- SGN
- murine postnatal model
- spiral ganglion explant culture
- neurite outgrowth
- in vitro
- NMRI mice
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Frick, Claudia
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Fink, Stefan
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Schmidbauer, Dom ...
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Rousset, Francis
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Eickhoff, Holger
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Tropitzsch, Anke
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visa fler...
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Kramer, Benedikt
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Senn, Pascal
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Glueckert, Rudol ...
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Rask-Andersen, H ...
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Wiesmüller, Karl ...
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Löwenheim, Huber ...
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Müller, Marcus
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Brain Sciences
- Av lärosätet
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Uppsala universitet