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Graft-versus-Mastoc...
Graft-versus-Mastocytosis Effect After Donor Lymphocyte Infusion : Proof of Principle.
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- Hägglund, Hans (författare)
- Uppsala universitet,Hematologi,Uppsala Univ, Sweden; Uppsala Univ Hosp, Sweden
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- Selim Yavuz, Akif (författare)
- Uppsala Univ, Sweden; Uppsala Univ Hosp, Sweden
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- Dreimane, Arta (författare)
- Region Östergötland, Hematologiska kliniken US
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- Malm, Claes (författare)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Hematologiska kliniken US
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- Sundin, Anders, 1954- (författare)
- Uppsala universitet,Radiologi,Uppsala Univ, Sweden; Uppsala Univ Hosp, Sweden
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- Sander, Birgitta (författare)
- Karolinska Institutet,Karolinska Inst, Sweden
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- Nilsson, Gunnar (författare)
- Karolinska Institutet,Uppsala universitet,Hematologi,Uppsala Univ, Sweden; Uppsala Univ Hosp, Sweden; Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
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(creator_code:org_t)
- 2020-12
- 2021
- Engelska.
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Ingår i: European Journal of Haematology. - : John Wiley & Sons. - 0902-4441 .- 1600-0609. ; 106:2, s. 290-293
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Abstract
Ämnesord
Stäng
- Advanced systemic mastocytosis is a relatively rare entity where allogeneic stem cell transplantation can lead to cure of the disease in selected patients. Delayed incomplete responses with graft versus mastocytosis effect were published in a few cases. In this particular patient's report, we describe the direct evidence and potency of graft versus mastocytosis effect of donor lymphocyte infusions in a patient with systemic mastocytosis with associated hematological neoplasm (SM-AHN). In a 53-year-old female patient, an allogeneic stem cell transplantation after conventional induction treatment was performed for transformed acute myeloid leukemia (AML) during the course of polycythemia vera. After 6 years of remission period of AML and PV, the patient developed aleukemic mast cell leukemia and JAK2 positive myeloproliferative neoplasm (SM-AHN). We were able to achieve a sustained complete remission of SM-AHN lasting for 6 years with only donor lymphocyte infusions in a status of mixed chimerism. The patient is in a good clinical condition and remission. The potent graft versus mastocytosis effect in this patient resembles the favorable effect of donor lymphocyte infusions in relapsing chronic myeloid leukemia patients after transplantation. This patient is, to our knowledge, the first case showing the proof of principle of graft versus mastocytosis effect.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- donor lymphocyte infusion
- graft-versus-mastocytosis effect
- systemic mastocytosis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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