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Differences and sim...
Differences and similarities between cancer and somatic stem cells : therapeutic implications
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- Rossi, Fiorella (författare)
- Nova Southeastern Univ, NSU Cell Therapy Inst, 3301 Coll Ave,3200 South Univ Dr, Ft Lauderdale, FL 33328 USA.
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- Noren, Hunter (författare)
- Nova Southeastern Univ, NSU Cell Therapy Inst, 3301 Coll Ave,3200 South Univ Dr, Ft Lauderdale, FL 33328 USA.
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- Jove, Richard (författare)
- Nova Southeastern Univ, NSU Cell Therapy Inst, 3301 Coll Ave,3200 South Univ Dr, Ft Lauderdale, FL 33328 USA.
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- Beljanski, Vladimir (författare)
- Nova Southeastern Univ, NSU Cell Therapy Inst, 3301 Coll Ave,3200 South Univ Dr, Ft Lauderdale, FL 33328 USA.
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- Grinnemo, Karl-Henrik (författare)
- Uppsala universitet,Thoraxkirurgi,Nova Southeastern Univ, NSU Cell Therapy Inst, 3301 Coll Ave,3200 South Univ Dr, Ft Lauderdale, FL 33328 USA.;Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
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Nova Southeastern Univ, NSU Cell Therapy Inst, 3301 Coll Ave,3200 South Univ Dr, Ft Lauderdale, FL 33328 USA Thoraxkirurgi (creator_code:org_t)
- 2020-11-18
- 2020
- Engelska.
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Ingår i: Stem Cell Research & Therapy. - : BMC. - 1757-6512. ; 11:1
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://stemcellres....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Over the last decades, the cancer survival rate has increased due to personalized therapies, the discovery of targeted therapeutics and novel biological agents, and the application of palliative treatments. Despite these advances, tumor resistance to chemotherapy and radiation and rapid progression to metastatic disease are still seen in many patients. Evidence has shown that cancer stem cells (CSCs), a sub-population of cells that share many common characteristics with somatic stem cells (SSCs), contribute to this therapeutic failure. The most critical properties of CSCs are their self-renewal ability and their capacity for differentiation into heterogeneous populations of cancer cells. Although CSCs only constitute a low percentage of the total tumor mass, these cells can regrow the tumor mass on their own. Initially identified in leukemia, CSCs have subsequently been found in cancers of the breast, the colon, the pancreas, and the brain. Common genetic and phenotypic features found in both SSCs and CSCs, including upregulated signaling pathways such as Notch, Wnt, Hedgehog, and TGF-beta. These pathways play fundamental roles in the development as well as in the control of cell survival and cell fate and are relevant to therapeutic targeting of CSCs. The differences in the expression of membrane proteins and exosome-delivered microRNAs between SSCs and CSCs are also important to specifically target the stem cells of the cancer. Further research efforts should be directed toward elucidation of the fundamental differences between SSCs and CSCs to improve existing therapies and generate new clinically relevant cancer treatments.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Nyckelord
- Cancer stem cells
- Somatic stem cells
- Immunoregulation
- Targeted therapy
- Signaling pathways
- Clinical trials
- Cell surface markers
- Cellular differentiation
- Self-renewal
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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