Heart failure is a common complication after acute myocardial infarction in patients with diabetes: A nationwide study in the SWEDEHEART registry.

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Ritsinger, VivecaKarolinska Institutet (author)

Heart failure is a common complication after acute myocardial infarction in patients with diabetes : A nationwide study in the SWEDEHEART registry.

Article/chapterEnglish2020

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2020-11-01
Oxford University Press (OUP),2020
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LIBRIS-ID:oai:DiVA.org:uu-430019
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-430019URI
https://doi.org/10.1177/2047487319901063DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:142969001URI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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BACKGROUND: Several glucose lowering drugs with preventive effects on heart failure and death have entered the market, however, still used in low proportions after acute myocardial infarction. We explored the complication rates of heart failure and death after acute myocardial infarction in patients with and without diabetes.METHODS: All patients (N = 73,959) with acute myocardial infarction admitted for coronary angiography included in the SWEDEHEART registry during the years 2012-2017 were followed for heart failure (until 31 December 2017) and mortality (until 30 June 2018); mean follow-up time 1223 (SD ± 623) days.RESULTS: Mean age was 69 years (SD ± 12), 69% were male and 24% had diabetes. Heart failure occurred more often in diabetes (22% vs. 12% if no diabetes), especially if previous MI (33% vs. 23%). Patients with diabetes had increased risk of HF regardless of previous myocardial infarction (MI); with previous MI adjusted hazard ratio 2.09 (95% confidence interval 1.96-2.20) and without MI 1.52 (1.44-1.61) respectively when non-diabetes patients with first MI served as reference. In patients with no previous heart failure or MI and discharged with left ventricular ejection fraction ≥50% the risk of heart failure was particularly high in those with diabetes (1.56; 1.39-1.76) when compared with those without. Similar findings were seen for death and combined event (heart failure and death).CONCLUSIONS: Heart failure is a common complication after acute myocardial infarction in diabetes, increasing the risk by 50-60% regardless of previous heart failure or MI. This risk is present even with normal reported left ventricular ejection fraction, indicating the existence of a large diabetes population at heart failure risk after acute myocardial infarction.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
Heart failure
acute myocardial infarction
diabetes
prognosis

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Nyström, ThomasKarolinska Institutet (author)
Saleh, NawsadKarolinska Institutet (author)
Lagerqvist, Bo,1952-Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi(Swepub:uu)bolager (author)
Norhammar, AnnaKarolinska Institutet (author)
Karolinska InstitutetUppsala kliniska forskningscentrum (UCR) (creator_code:org_t)

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In:European Journal of Preventive Cardiology: Oxford University Press (OUP)27:17, s. 1890-19012047-48732047-4881

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