Sökning: onr:"swepub:oai:DiVA.org:uu-437154" >
Intratumoral immuno...
Intratumoral immunostimulatory AdCD40L gene therapy in patients with advanced solid tumors.
-
- Irenaeus, Sandra (författare)
- Uppsala universitet,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab
-
- Hellström, Vivan (författare)
- Uppsala universitet,Transplantationskirurgi
-
- Wenthe, Jessica (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
-
visa fler...
-
- Krause, Johan, 1956- (författare)
- Uppsala universitet,Radiologi
-
- Sundin, Anders, 1954- (författare)
- Uppsala universitet,Radiologi
-
- Ahlström, Håkan, 1953- (författare)
- Uppsala universitet,Radiologi
-
- Tufveson, Gunnar (författare)
- Uppsala universitet,Transplantationskirurgi
-
- Tötterman, Thomas H (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
-
- Loskog, Angelica S., 1973- (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
-
Ullenhag, Gustav (författare)
-
visa färre...
-
(creator_code:org_t)
- 2020-12-14
- 2021
- Engelska.
-
Ingår i: Cancer Gene Therapy. - : Springer Science and Business Media LLC. - 0929-1903 .- 1476-5500. ; 28:10-11, s. 1188-1197
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- AdCD40L is a replication-deficient virus carrying the gene for CD40 ligand which has previously been evaluated in patients with urothelial cancer and malignant melanoma. Herein, we present the results of repeated intratumoral injections of AdCD40L in seven patients with metastatic solid cancer. One patient who developed urothelial cancer derived from a renal transplant was treated with repeated injections of AdCD40L alone. The remaining patients suffered from cholangiocarcinoma, kidney, breast, rectal, or ovarian cancer and received AdCD40L repeatedly (4x) in combination with cyclophosphamide. The treatment was safe and generally well-tolerated. Two patients had clinical benefit of the treatment and one of them was accepted for re-treatment. Circulating proinflammatory cytokines were commonly increased after treatment, but save for TNFα, significances were not reached which could be due to the low number of patients. Similar to earlier findings in AdCD40L-treated melanoma patients, IL8 plasma levels were high in the present study. In conclusion, gene therapy by repeated intratumoral AdCD40L injections alone, or in combination with cyclophosphamide, is feasible and safe in patients with solid cancers. The potential of intratumoral CD40L gene transfer as treatment of cancer was illustrated by the clinical improvement in two out of seven patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Irenaeus, Sandra
-
Hellström, Vivan
-
Wenthe, Jessica
-
Krause, Johan, 1 ...
-
Sundin, Anders, ...
-
Ahlström, Håkan, ...
-
visa fler...
-
Tufveson, Gunnar
-
Tötterman, Thoma ...
-
Loskog, Angelica ...
-
Ullenhag, Gustav
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
- Artiklar i publikationen
-
Cancer Gene Ther ...
- Av lärosätet
-
Uppsala universitet