PET radioligands for the dopamine D1-receptor: Application in psychiatric disorders

PET radioligands for the dopamine D1-receptor : Application in psychiatric disorders

(creator_code:org_t)

Elsevier BV, 2019
2019
English.
In: Neuroscience Letters. - : Elsevier BV. - 0304-3940 .- 1872-7972. ; 691, s. 26-34

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Abstract Subject headings

The dopamine (DA) system is considered to be centrally involved in the pathophysiotogy of several major psychiatric disorders. Using positron emission tomography (PET), aberrations in dopamine D2/D3-receptors (D2-R) levels and uptake of the DA precursor FDOPA have been shown for schizophrenia, substance abuse and depression. Radioligands for the dopamine D1-receptor (D1-R) have been available for more than three decades, however this receptor subtype has received much less attention in psychiatry research. Here, studies investigating D1-R in psychiatric patients in comparison to healthy control subjects are summarized. Although small sample sizes, medication effects and heterogeneous methods of quantification limit the conclusions that can be drawn, the data is suggestive of higher levels of cortical D1-R in drug naive patients with psychosis, and lower D1-R in patients with affective disorders. Data sharing and reanalysis using harmonized methodology are important next steps towards clarifying the role of D1-R in these disorders.

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

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