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Quality of Life in ...
Quality of Life in Vulnerable Older Patients with Metastatic Colorectal Cancer Receiving Palliative Chemotherapy : The Randomized NORDIC9-Study
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- Liposits, Gabor (författare)
- Odense Univ Hosp, Dept Oncol, DK-5000 Odense, Denmark; Univ Southern Denmark, Dept Clin Res, DK-5000 Odense, Denmark; Acad Geriatr Canc Res AgeCare, DK-5000 Odense, Denmark
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- Eshoj, Henrik Rode (författare)
- Odense Univ Hosp, Qual Life Res Ctr, Dept Haematol, DK-5000 Odense, Denmark
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- Möller, Sören (författare)
- Univ Southern Denmark, Dept Clin Res, DK-5000 Odense, Denmark; Odense Univ Hosp, OPEN Open Patient Data Explorat Network, DK-5000 Odense, Denmark
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- Braendegaard Winther, Stine (författare)
- Odense Univ Hosp, Dept Oncol, DK-5000 Odense, Denmark; Acad Geriatr Canc Res AgeCare, DK-5000 Odense, Denmark
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- Skuladottir, Halla (författare)
- Reg Hosp West Jutland, Dept Oncol, DK-7400 Herning, Denmark
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- Ryg, Jesper (författare)
- Univ Southern Denmark, Dept Clin Res, DK-5000 Odense, Denmark; Acad Geriatr Canc Res AgeCare, DK-5000 Odense, Denmark; Odense Univ Hosp, Dept Geriatr Med, DK-5000 Odense, Denmark
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- Hofsli, Eva (författare)
- Trondheim Reg & Univ Hosp, Dept Oncol, N-7030 Trondheim, Norway; Norwegian Univ Sci & Technol, Dept Clin & Mol Med, N-7030 Trondheim, Norway
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- Shah, Carl-Henrik (författare)
- Karolinska Univ Hosp, Theme Canc, S-17176 Stockholm, Sweden
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- Østergaard Poulsen, Laurids (författare)
- Aalborg Univ Hosp, Dept Oncol, DK-9000 Aalborg, Denmark
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- Berglund, Åke (författare)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Qvortrup, Camilla (författare)
- Acad Geriatr Canc Res AgeCare, DK-5000 Odense, Denmark
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- Österlund, Pia (författare)
- Karolinska Institutet
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- Glimelius, Bengt (författare)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Sorbye, Halfdan (författare)
- Haukeland Hosp, Dept Oncol, N-5021 Bergen, Norway; Univ Bergen, Dept Clin Sci, N-5021 Bergen, Norway
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- Pfeiffer, Per (författare)
- Odense Univ Hosp, Dept Oncol, DK-5000 Odense, Denmark; Univ Southern Denmark, Dept Clin Res, DK-5000 Odense, Denmark; Acad Geriatr Canc Res AgeCare, DK-5000 Odense, Denmark
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Poulsen, LO (författare)
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(creator_code:org_t)
- 2021-05-26
- 2021
- Engelska.
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Ingår i: Cancers. - : MDPI. - 2072-6694. ; 13:11
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Quality of life data from randomized trials are lacking in older patients with metastatic colorectal cancer (mCRC). In the randomized NORDIC9-study, reduced-dose S1+oxaliplatin (SOx) showed superior efficacy compared to full-dose S1 monotherapy. We hypothesized that treatment with SOx does not result in inferior quality of life. Patients with mCRC aged ≥70 years and that were not a candidate for standard combination chemotherapy were included and randomly assigned to receive either S1 or SOx. The EORTC QLQ-C30 questionnaire was completed at baseline, after 9, and 18 weeks. The primary endpoint was global Quality of Life (QoL) at 9 weeks. For statistical analysis, a non-inferiority design was chosen applying linear mixed effects models for repeated measurements. The results were interpreted according to statistical significance and anchor-based, clinically relevant between-group minimally important differences (MID). A total of 160 patients aged (median (Interquartile range (IQR))) 78 years (76–81) were included. The QLQ-C30 questionnaire was completed by 150, 100, and 60 patients at baseline, at 9, and 18 weeks, respectively. The difference at 9 weeks in global QoL was 6.85 (95%CI—1.94; 15.65) and 7.37 (0.70; 14.05) in the physical functioning domain in favor of SOx exceeding the threshold for MID. At 18 weeks, the between-group MID in physical functioning was preserved. Dose-reduced combination chemotherapy may be recommended in vulnerable older patients with mCRC, rather than full-dose monotherapy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- older adults
- metastatic colorectal cancer
- chemotherapy
- vulnerability
- quality of life
- physical functioning
- EORTC QLQ-C30
- geriatric oncology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
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Cancers
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Till lärosätets databas
- Av författaren/redakt...
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Liposits, Gabor
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Eshoj, Henrik Ro ...
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Möller, Sören
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Braendegaard Win ...
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Skuladottir, Hal ...
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Ryg, Jesper
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visa fler...
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Hofsli, Eva
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Shah, Carl-Henri ...
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Østergaard Pouls ...
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Berglund, Åke
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Qvortrup, Camill ...
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Österlund, Pia
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Glimelius, Bengt
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Sorbye, Halfdan
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Pfeiffer, Per
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Poulsen, LO
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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Cancers
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet