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Unintended fusion i...
Unintended fusion in cervical artificial disk replacement : a prospective study on heterotopic ossification, progression, and clinical outcome, with 5-year follow-up
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- Marques, Catarina, 1969- (författare)
- Uppsala universitet,Ortopedi
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- MacDowall, Anna (författare)
- Uppsala universitet,Ortopedi
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- Skeppholm, Martin (författare)
- Karolinska Inst, Dept Learning Informat Management & Eth, Stockholm, Sweden.
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- Moreira, Nuno Canto (författare)
- Karolinska Univ Sjukhuset Solna, Dept Clin Neurosci CNS, Pediat Radiol Sect, K8, Stockholm, Sweden.
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- Olerud, Claes (författare)
- Uppsala universitet,Ortopedi
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(creator_code:org_t)
- 2021-01-20
- 2021
- Engelska.
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Ingår i: European spine journal. - : Springer. - 0940-6719 .- 1432-0932. ; 30:6, s. 1662-1669
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://link.springe...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Purpose Heterotopic ossification (HO) may cause unintended fusion in artificial disk replacement (ADR), failing to preserve motion. The reported incidence of HO varies hugely. This study aimed to determine prevalence of HO, progression, predisposing factors to occurrence and to progression, and potential effect on clinical outcomes. Methods Eighty-three patients treated with ADRs for cervical radiculopathy at one or two segments were extracted from a previously published RCT. Of the 83 patients, 59 had remaining ADR (79 implants) and sufficiently high-quality X-rays at 5 years of follow-up to allow analysis. HO was graded on plain films according to Mehren/Suchomel. Prevalence, progression, predisposing factors and effect on clinical outcome (Neck Disability Index-NDI) were analyzed. Results At 2 years, HO was seen in 46/55 ADR implants (84%), severe enough to affect mobility in 27/55 (49%). At 5 years, HO was seen in 92% of 79 implants, severe in 71%. Male sex was a predisposing factor to HO. No predisposing factors to progression were identified. NDI was not affected by the severity of HO. Conclusion Almost all ADR implants in our study have HO at 5 years of follow-up. Male sex is a risk factor. Severe HO did not affect clinical outcome.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- Cervical radiculopathy
- Artificial disk replacement
- Fusion
- Heterotopic ossification
- Treatment outcome
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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