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Novel biomarkers de...
Novel biomarkers detected by proteomics predict death and cardiovascular events in hemodialysis patients
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- Wu, Ping-Hsun, 1982- (author)
- Uppsala universitet,Endokrinologi och mineralmetabolism,Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
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- Glerup, Rie Io (author)
- Department of Nephrology, Aalborg University Hospital, Aalborg, Denmark
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- Svensson, My Hanna Sofia (author)
- Division of Medicine, Department of Nephrology, Akershus University Hospital, Oslo, Norway
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- Eriksson, Niclas, 1978- (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
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- Christensen, Jeppe Hagstrup (author)
- Department of Nephrology, Aalborg University Hospital, Aalborg, Denmark
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- de Laval, Philip (author)
- Uppsala universitet,Njurmedicin
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- Soveri, Inga (author)
- Uppsala universitet,Njurmedicin
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- Westerlund, Magnus (author)
- Uppsala universitet,Njurmedicin
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- Linde, Torbjörn (author)
- Uppsala universitet,Njurmedicin
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- Ljunggren, Östen (author)
- Uppsala universitet,Endokrinologi och mineralmetabolism
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- Fellström, Bengt, 1947- (author)
- Uppsala universitet,Njurmedicin
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(creator_code:org_t)
- English.
- Related links:
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https://urn.kb.se/re...
Abstract
Subject headings
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- Background. End-stage kidney disease increases mortality and the risk of cardiovascular (CV) disease. It is crucial to explore novel biomarkers to predict CV disease in the complex setting of patients receiving hemodialysis (HD). This study investigated the association between 92 targeted proteins with all-cause death, CV death, and composite vascular events (CVEs) in HD patients.Methods. From December 2010 to March 2011, 331 HD patients were included and followed prospectively for 5 years. Serum was analyzed for 92 CV-related proteins using Proseek Multiplex Cardiovascular I panel, a high-sensitivity assay based on proximity extension assay (PEA) technology. The association between biomarkers and all-cause death, CV death, and CVEs was evaluated by Cox-regression analyses.Results. Of the PEA-based proteins, we identified 20 proteins associated with risk of all-cause death, 7 proteins associated with risk of CV death, and 17 proteins associated with risk of CVEs, independent of established risk factors. Interleukin-8 (IL-8), T-cell immunoglobulin and mucin domain 1 (TIM-1), and C-C motif chemokine 20 (CCL20) were associated with increased risk of all-cause death, CV death, and CVE in multivariable-adjusted models. Stem cell factor (SCF) and Galanin peptides (GAL) were associated with both decreased risk of all-cause death and CV death.Conclusions. IL-8, TIM-1, and CCL20 predicted death and CV outcomes in HD patients. Novel findings were that SCF and GAL were associated with a lower risk of all death and CV death. The SCF warrants further study with regards to its possible biological effect in HD patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- death
- cardiovascular disease
- proteomics
- hemodialysis
- biomarkers
- Medicinsk vetenskap
- Medical Science
Publication and Content Type
- vet (subject category)
- ovr (subject category)
To the university's database
- By the author/editor
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Wu, Ping-Hsun, 1 ...
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Glerup, Rie Io
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Svensson, My Han ...
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Eriksson, Niclas ...
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Christensen, Jep ...
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de Laval, Philip
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show more...
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Soveri, Inga
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Westerlund, Magn ...
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Linde, Torbjörn
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Ljunggren, Östen
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Fellström, Bengt ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- By the university
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Uppsala University