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  • Aasebø, Kristine (author)

Prognostic role of tumour-infiltrating lymphocytes and macrophages in relation to MSI, CDX2 and BRAF status : a population-based study of metastatic colorectal cancer patients

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2021-10-20
  • Springer,2022
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-459242
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-459242URI
  • https://doi.org/10.1038/s41416-021-01586-5DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

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  • BACKGROUND: Tumour-infiltrating CD3, CD8 lymphocytes and CD68 macrophages are associated with favourable prognosis in localised colorectal cancer, but the effect in metastatic colorectal cancer (mCRC) is not established.METHODS: A Scandinavian population-based cohort of non-resectable mCRC patients was studied. Tissue microarrays (n = 460) were stained with CD3, CD8 and CD68 using fluorescence-based multiplex immunohistochemistry. Associations with clinicopathological variables, overall survival (OS) and progression-free survival were estimated.RESULTS: Two-thirds of microsatellite instable (MSI) and one-fourth of microsatellite stable (MSS) tumours displayed the highest quartile density of CD8. For CD3 high vs low cases, median OS was 20 vs 16 months (HR: 0.76, 95% CI: 0.59, 0.76, p = 0.025) with 3-year OS of 27 vs 13%. For CD68 high vs low cases, median OS was 23 vs 15 months (HR: 0.69, 95% CI: 0.54, 0.88, p = 0.003) with 3-year OS of 28 vs 12%. MSI, BRAF mutation and CDX2 loss were negative prognostic markers independent of tumour immune infiltration.CONCLUSIONS: In mCRC, high lymphocyte infiltration was found in proportions of MSI and MSS tumours-potential subgroups of immunotherapy response. Tumour-infiltrating CD3 lymphocytes and CD68 macrophages were associated with median and long-term survival. MSI was a significant negative prognostic marker despite high immunogenicity.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Bruun, Jarle (author)
  • Bergsland, Christian H (author)
  • Nunes, Luís,1995-Uppsala universitet,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)luinu972 (author)
  • Eide, Geir Egil (author)
  • Pfeiffer, Per (author)
  • Dahl, Olav (author)
  • Glimelius, BengtUppsala universitet,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)bengglim (author)
  • Lothe, Ragnhild A (author)
  • Sorbye, Halfdan (author)
  • Uppsala universitetExperimentell och klinisk onkologi (creator_code:org_t)

Related titles

  • In:British Journal of Cancer: Springer126:1, s. 48-560007-09201532-1827

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