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UNGAP best practice...
UNGAP best practice for improving solubility data quality of orally administered drugs
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- Vertzoni, M. (author)
- Natl & Kapodistrian Univ Athens, Dept Pharm, Zografos, Greece.
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- Alsenz, J. (author)
- Roche Pharmaceut Res & Early Dev, Basel, Switzerland.
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- Augustijns, P. (author)
- Katholieke Univ Leuven, Drug Delivery & Disposit, Leuven, Belgium.
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- Bauer-Brandl, A. (author)
- Univ Southern Denmark, Dept Phys Chem & Pharm, Odense, Denmark.
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- Bergström, Christel A. S., 1973- (author)
- Uppsala universitet,Institutionen för farmaci
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- Brouwers, J. (author)
- Katholieke Univ Leuven, Drug Delivery & Disposit, Leuven, Belgium.
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- Mullerz, A. (author)
- Univ Copenhagen, Dept Pharm, Copenhagen, Denmark.
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- Perlovich, G. (author)
- Russian Acad Sci, Inst Solut Chem, Dept Phys Chem Drugs, Ivanovo, Russia.
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- Saal, C. (author)
- Merck KGaA, Analyt Healthcare, Darmstadt, Germany.
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- Sugano, K. (author)
- Ritsumeikan Univ, Coll Pharmaceut Sci, Kusatsu, Japan.
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- Reppas, C. (author)
- Natl & Kapodistrian Univ Athens, Dept Pharm, Zografos, Greece.
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Natl & Kapodistrian Univ Athens, Dept Pharm, Zografos, Greece Roche Pharmaceut Res & Early Dev, Basel, Switzerland. (creator_code:org_t)
- Elsevier, 2022
- 2022
- English.
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In: European Journal of Pharmaceutical Sciences. - : Elsevier. - 0928-0987 .- 1879-0720. ; 168
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Abstract
Subject headings
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- An important goal of the European Cooperation in Science and Technology (COST) Action UNGAP (UNder-standing Gastrointestinal Absorption-related Processes, www.ungap.eu) is to improve standardization of methods relating to the study of oral drug absorption. Solubility is a general term that refers to the maximum achievable concentration of a compound dissolved in a liquid medium. For orally administered drugs, relevant information on drug properties is crucial during drug (product) development and at the regulatory level. Collection of reliable and reproducible solubility data requires careful application and understanding of the limitations of the selected experimental method. In addition, the purity of a compound and its solid state form, as well as experimental parameters such as temperature of experimentation, media related factors, and sample handling procedures can affect data quality. In this paper, an international consensus developed by the COST UNGAP network on recommendations for collecting high quality solubility data for the development of orally administered drugs is proposed.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- Oral drug absorption
- Solubility
- Terminology
- Exerimental Methods
- Best Practice
- UNGAP
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Vertzoni, M.
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Alsenz, J.
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Augustijns, P.
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Bauer-Brandl, A.
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Bergström, Chri ...
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Brouwers, J.
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show more...
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Mullerz, A.
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Perlovich, G.
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Saal, C.
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Sugano, K.
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Reppas, C.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmaceutical S ...
- Articles in the publication
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European Journal ...
- By the university
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Uppsala University