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Molecular Mechanism...
Molecular Mechanisms Leading from Periodontal Disease to Cancer
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- Sobocki, Bartosz Kamil (författare)
- Med Univ Gdansk, Sci Circle Oncol & Radiotherapy, Mariana Smoluchowskiego 17 St, PL-80214 Gdansk, Poland.
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- Basset, Charbel A. (författare)
- Univ Palermo, Inst Human Anat & Histol, Dept Biomed Neurosci & Adv Diagnost, I-90127 Palermo, Italy.
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- Bruhn-Olszewska, Bozena (författare)
- Uppsala universitet,Medicinsk genetik och genomik,Uppsala Univ, Dept Immunol, Genet & Pathol & Sci Life Lab, BMC Husargatan 3, S-75108 Uppsala, Sweden.
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- Olszewski, Pawel K. (författare)
- Uppsala universitet,Medicinsk genetik och genomik,Uppsala Univ, Dept Med Biochem & Microbiol, BMC Husargatan 3, S-75108 Uppsala, Sweden.
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- Szot, Olga (författare)
- Med Univ Gdansk, Sci Circle Oncol & Radiotherapy, Mariana Smoluchowskiego 17 St, PL-80214 Gdansk, Poland.
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- Kazmierczak-Siedlecka, Karolina (författare)
- Med Univ Gdansk, Dept Surg Oncol, Mariana Smoluchowskiego 17 St, PL-80214 Gdansk, Poland.
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- Guziak, Mateusz (författare)
- Med Univ Gdansk, Sci Circle Oncol & Radiotherapy, Mariana Smoluchowskiego 17 St, PL-80214 Gdansk, Poland.
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- Nibali, Luigi (författare)
- Kings Coll London, Ctr Host Microbiome Interact, Periodontol Unit, Fac Dent Oral & Craniofacial Sci, London SE1 9RT, England.
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- Leone, Angelo (författare)
- Univ Palermo, Inst Human Anat & Histol, Dept Biomed Neurosci & Adv Diagnost, I-90127 Palermo, Italy.
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Med Univ Gdansk, Sci Circle Oncol & Radiotherapy, Mariana Smoluchowskiego 17 St, PL-80214 Gdansk, Poland Univ Palermo, Inst Human Anat & Histol, Dept Biomed Neurosci & Adv Diagnost, I-90127 Palermo, Italy. (creator_code:org_t)
- 2022-01-16
- 2022
- Engelska.
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Ingår i: International Journal of Molecular Sciences. - : MDPI. - 1661-6596 .- 1422-0067. ; 23:2
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Periodontitis is prevalent in half of the adult population and raises critical health concerns as it has been recently associated with an increased risk of cancer. While information about the topic remains somewhat scarce, a deeper understanding of the underlying mechanistic pathways promoting neoplasia in periodontitis patients is of fundamental importance. This manuscript presents the literature as well as a panel of tables and figures on the molecular mechanisms of Porphyromonas gingivalis and Fusobacterium nucleatum, two main oral pathogens in periodontitis pathology, involved in instigating tumorigenesis. We also present evidence for potential links between the RANKL-RANK signaling axis as well as circulating cytokines/leukocytes and carcinogenesis. Due to the nonconclusive data associating periodontitis and cancer reported in the case and cohort studies, we examine clinical trials relevant to the topic and summarize their outcome.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- periodontal disease
- cancer
- tumorigenesis
- Fusobacterium nucleatum
- Porphyromonas gingivalis
- RANK ligand
- immune response
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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