Sökning: onr:"swepub:oai:DiVA.org:uu-474007" > Epigenomic priming ...
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000 | 05167naa a2200541 4500 | |
001 | oai:DiVA.org:uu-474007 | |
003 | SwePub | |
008 | 220508s2022 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:149381826 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4740072 URI |
024 | 7 | a https://doi.org/10.1016/j.neuron.2021.12.0342 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1493818262 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Meijer, Mandyu Karolinska Institutet4 aut |
245 | 1 0 | a Epigenomic priming of immune genes implicates oligodendroglia in multiple sclerosis susceptibility |
264 | 1 | b Elsevier,c 2022 |
338 | a electronic2 rdacarrier | |
520 | a Multiple sclerosis (MS) is characterized by a targeted attack on oligodendroglia (OLG) and myelin by immune cells, which are thought to be the main drivers of MS susceptibility. We found that immune genes exhibit a primed chromatin state in single mouse and human OLG in a non-disease context, compatible with transitions to immune-competent states in MS. We identified BACH1 and STAT1 as transcription factors involved in immune gene regulation in oligodendrocyte precursor cells (OPCs). A subset of immune genes presents bivalency of H3K4me3/H3K27me3 in OPCs, with Polycomb inhibition leading to their increased activation upon interferon gamma (IFN-g) treatment. Some MS susceptibility single-nucleotide polymorphisms (SNPs) overlap with these regulatory regions in mouse and human OLG. Treatment of mouse OPCs with IFN-g leads to chromatin architecture remodeling at these loci and altered expression of interacting genes. Thus, the susceptibility for MS may involve OLG, which therefore constitutes novel targets for immunological based therapies for MS. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
700 | 1 | a Agirre, Eneritzu Karolinska Institutet4 aut |
700 | 1 | a Kabbe, Mukundu Karolinska Inst, Dept Med Biochem & Biophys, Lab Mol Neurobiol, S-17177 Stockholm, Sweden.4 aut |
700 | 1 | a van Tuijn, Cassandra A.u Karolinska Inst, Dept Med Biochem & Biophys, Lab Mol Neurobiol, S-17177 Stockholm, Sweden.4 aut |
700 | 1 | a Heskol, Abeeru Karolinska Inst, Dept Med Biochem & Biophys, Lab Mol Neurobiol, S-17177 Stockholm, Sweden.;Inst Gulbenkian Ciencias, P-2780156 Oeiras, Portugal.4 aut |
700 | 1 | a Zheng, Chaou Karolinska Inst, Dept Med Biochem & Biophys, Lab Mol Neurobiol, S-17177 Stockholm, Sweden.4 aut |
700 | 1 | a Falcao, Ana Mendanhau Karolinska Inst, Dept Med Biochem & Biophys, Lab Mol Neurobiol, S-17177 Stockholm, Sweden.;Univ Minho, Sch Med, Life & Hlth Sci Res Inst ICVS, Braga, Portugal.;PT Govt Associate Lab, ICVS 3Bs Associate Lab, P-4710057 Braga, Portugal.4 aut |
700 | 1 | a Bartosovic, Mareku Karolinska Inst, Dept Med Biochem & Biophys, Lab Mol Neurobiol, S-17177 Stockholm, Sweden.4 aut |
700 | 1 | a Kirby, Leslieu Karolinska Inst, Dept Med Biochem & Biophys, Lab Mol Neurobiol, S-17177 Stockholm, Sweden.4 aut |
700 | 1 | a Calini, Danielau Roche Pharma Res & Early Dev, CH-4070 Basel, Switzerland.4 aut |
700 | 1 | a Johnson, Michael R.u Imperial Coll London, Fac Med, Dept Brain Sci, London SW7 2AZ, England.4 aut |
700 | 1 | a Corces, M. Ryanu Gladstone Inst Neurol Dis, San Francisco, CA 94158 USA.;Stanford Univ, Ctr Personal Dynam Regulomes, Stanford, CA 94305 USA.;Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USA.;Stanford Univ, Dept Pathol, Sch Med, Stanford, CA 94305 USA.4 aut |
700 | 1 | a Montine, Thomas J.u Stanford Univ, Dept Pathol, Sch Med, Stanford, CA 94305 USA.4 aut |
700 | 1 | a Chen, Xingqiu Uppsala universitet,Molekylära verktyg,Stanford Univ, Ctr Personal Dynam Regulomes, Stanford, CA 94305 USA.;Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USA.4 aut0 (Swepub:uu)xinch196 |
700 | 1 | a Chang, Howard Y.u Stanford Univ, Ctr Personal Dynam Regulomes, Stanford, CA 94305 USA.;Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USA.4 aut |
700 | 1 | a Malhotra, Dheeraju Roche Pharma Res & Early Dev, CH-4070 Basel, Switzerland.4 aut |
700 | 1 | a Castelo-Branco, Goncalou Karolinska Institutet4 aut |
710 | 2 | a Karolinska Institutetb Karolinska Inst, Dept Med Biochem & Biophys, Lab Mol Neurobiol, S-17177 Stockholm, Sweden.4 org |
773 | 0 | t Neurond : Elsevierg 110:7, s. 1193-1210q 110:7<1193-1210x 0896-6273x 1097-4199 |
856 | 4 | u https://doi.org/10.1016/j.neuron.2021.12.034y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1656813/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u http://www.cell.com/article/S0896627321010898/pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-474007 |
856 | 4 8 | u https://doi.org/10.1016/j.neuron.2021.12.034 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:149381826 |
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