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Abdominal Complicat...
Abdominal Complications During Treatment for Pediatric Acute Myeloid Leukemia
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- Borgstedt-Bendixen, Sofie E. (author)
- Aarhus Univ Hosp, Dept Pediat & Adolescent Med, Aarhus, Denmark.
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- Abrahamsson, Jonas (author)
- Queen Silvia Childrens Hosp, Inst Clin Sci, Dept Pediat, Gothenburg, Sweden.
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- Ha, Shau-Yin (author)
- Queen Mary Hosp, Dept Pediat, Hong Kong, Peoples R China.;Hong Kong Pediat Hematol & Oncol Study Grp HKPHOS, Hong Kong, Peoples R China.
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- Koskenvuo, Minna (author)
- Childrens Hosp & Helsinki Univ Cent Hosp, Div Hematol Oncol & Stem Cell Transplantat, Helsinki, Finland.
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- Lausen, Birgitte (author)
- Univ Copenhagen, Dept Pediat & Adolescent Med, Rigshospitalet, Copenhagen, Denmark.
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- Palle, Josefine, 1964- (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Science for Life Laboratory, SciLifeLab
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- Zeller, Bernward (author)
- Oslo Univ Hosp, Div Pediat & Adolescent Med, Oslo, Norway.
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- Hasle, Henrik (author)
- Aarhus Univ Hosp, Dept Pediat & Adolescent Med, Aarhus, Denmark.
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- Lohmann, Ditte J. A. (author)
- Aarhus Univ Hosp, Dept Pediat & Adolescent Med, Aarhus, Denmark.
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Aarhus Univ Hosp, Dept Pediat & Adolescent Med, Aarhus, Denmark Queen Silvia Childrens Hosp, Inst Clin Sci, Dept Pediat, Gothenburg, Sweden. (creator_code:org_t)
- Ovid Technologies (Wolters Kluwer Health), 2022
- 2022
- English.
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In: Journal of Pediatric Hematology/Oncology. - : Ovid Technologies (Wolters Kluwer Health). - 1077-4114 .- 1536-3678. ; 44:5, s. 220-229
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Acute myeloid leukemia (AML) accounts for 15% to 20% of childhood leukemias. Because of high-intensive therapy, up to 5% of patients suffer from treatment-related mortality (TRM). Abdominal complications are frequent, however, literature on this subject is sparse. We aimed to characterize severe abdominal pain (AP) and hyperbilirubinemia experienced by pediatric AML patients treated according to the Nordic Society of Pediatric Hematology and Oncology (NOPHO)-AML 2004 protocol (n=313). Patients were censored at hematopoietic stem cell transplantation and relapse. Toxicity information was collected prospectively. Additional information was requested retrospectively from the treating centers. Sixteen episodes of hyperbilirubinemia and 107 episodes of AP were reported. The treating centers deemed infection (30%) and typhlitis (18%) as the most frequent causes of AP. Six patients developed appendicitis (2%). Patients experiencing concurrent AP and sepsis had a high risk of TRM (36%, n=4). Eighty percent of episodes with hyperbilirubinemia fulfilled the European Society for Bone and Marrow Transplantation criteria for sinusoidal obstruction syndrome. In conclusion, abdominal complications were frequent with infection considered the predominate cause. Most patients with hyperbilirubinemia fulfilled the criteria for sinusoidal obstruction syndrome. AML treatment might be associated with appendicitis. Patients suffering from concurrent AP and sepsis had a high risk of TRM indicating that high awareness of abdominal complications is essential to reduce mortality, especially during sepsis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Keyword
- acute myeloid leukemia
- pediatric
- typhlitis
- appendicitis
- sinusoidal obstruction syndrome
Publication and Content Type
- ref (subject category)
- art (subject category)
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