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Association of adol...
Association of adolescent depression with subsequent prescriptions of anti-infectives and anti-inflammatories in adulthood : A longitudinal cohort study
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- Ssegonja, Richard (author)
- Uppsala universitet,Socialmedicin/CHAP,Lung- allergi- och sömnforskning
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- Alaie, Iman (author)
- Karolinska Institutet,Uppsala universitet,Barn- och ungdomspsykiatri,Karolinska Inst, Dept Clin Neurosci, Div Insurance Med, Stockholm, Sweden.
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- Holmgren, Amanda (author)
- Uppsala universitet,Barn- och ungdomspsykiatri
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- Bohman, Hannes, 1965- (author)
- Uppsala universitet,Barn- och ungdomspsykiatri
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- Päären, Aivar, 1965- (author)
- Uppsala universitet,Barn- och ungdomspsykiatri
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- von Knorring, Lars (author)
- Uppsala universitet,Psykiatri
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- von Knorring, Anne-Liis, 1945- (author)
- Uppsala universitet,Barn- och ungdomspsykiatri
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- Jonsson, Ulf, 1974- (author)
- Karolinska Institutet,Uppsala universitet,Barn- och ungdomspsykiatri,Karolinska Inst, Ctr Psychiat Res, Ctr Neurodev Disorders KIND, Dept Womens & Childrens Hlth, Stockholm, Sweden.;Stockholm Hlth Care Serv, Stockholm, Sweden.;Stockholm Hlth Care Serv, Child & Adolescent Psychiat, Stockholm, Sweden.
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(creator_code:org_t)
- Elsevier, 2022
- 2022
- English.
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In: Psychiatry Research. - : Elsevier. - 0165-1781 .- 1872-7123. ; 317
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Abstract
Subject headings
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- New insights into how depression is linked to physical health throughout the lifespan could potentially inform clinical decision making. The aim of this study was to explore the association of adolescent depression with subsequent prescriptions of anti-infectives and anti-inflammatories in adulthood. The study was based on the Uppsala Longitudinal Adolescent Depression Study (ULADS), a Swedish prospective cohort study initiated in 1991. Depressed (n = 321) and non-depressed (n = 218) adolescents were followed prospectively using patient registries. The associations of adolescent depression (age 16-17 years) with subsequent prescription of anti-infectives and anti-inflammatories (age 30-40 years), were analysed using generalized linear models. Sub -analyses explored the impact of diagnostic characteristics in adolescence and reception of anti-depressants prescriptions in adulthood. The results suggest that females with persistent depressive disorder in adolescence have a higher rate of future prescriptions than non-depressed peers, with adjusted incidence rate ratio of 1.42 (1.06 to 1.92) for anti-infectives and 1.72 (1.10 to 2.70) for anti-inflammatories. These associations were mainly driven by those who were also prescribed antidepressants during the same period. Associations were less robust for females with episodic or subsyndromal depression in adolescence and for males. These findings emphasize the importance of integrated mental health services at the primary healthcare level.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- Adolescent depression
- Persistent depressive disorder
- Prescriptions
- Anti-infectives
- Anti-inflammatories
Publication and Content Type
- ref (subject category)
- art (subject category)
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Ssegonja, Richar ...
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Alaie, Iman
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Holmgren, Amanda
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Bohman, Hannes, ...
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Päären, Aivar, 1 ...
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von Knorring, La ...
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von Knorring, An ...
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Jonsson, Ulf, 19 ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
- Articles in the publication
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Psychiatry Resea ...
- By the university
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Uppsala University
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Karolinska Institutet