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Differential Bias f...
Differential Bias for Creatinine- and Cystatin C- Derived Estimated Glomerular Filtration Rate in Critical COVID-19.
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- Larsson, Anders (författare)
- Uppsala University,Uppsala universitet,Klinisk kemi
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- Hultström, Michael, 1978- (författare)
- Uppsala University,Uppsala universitet,Anestesiologi och intensivvård,Integrativ Fysiologi,Department of Epidemiology, McGill University, Montréal, QC H3A 0G4, Canada.; Lady Davis Institute of Medical Research, Jewish General Hospital, Montréal, QC H3T 1E2, Canada.
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- Frithiof, Robert (författare)
- Uppsala University,Uppsala universitet,Anestesiologi och intensivvård
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- Nyman, Ulf (författare)
- Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,Department of Translational Medicine,Faculty of Medicine,Radiology Diagnostics, Malmö,Lund University Research Groups
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- Lipcsey, Miklós (författare)
- Uppsala University,Uppsala universitet,Hedenstiernalaboratoriet
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- Eriksson, Mats B (författare)
- Uppsala University,Uppsala universitet,Anestesiologi och intensivvård,NOVA Medical School, New University of Lisbon, 1099-085 Lisbon, Portugal.
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(creator_code:org_t)
- 2022-10-26
- 2022
- Engelska.
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Ingår i: Biomedicines. - : MDPI. - 2227-9059. ; 10:11
- Relaterad länk:
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https://doi.org/10.3...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- COVID-19 is a systemic disease, frequently affecting kidney function. Dexamethasone is standard treatment in severe COVID-19 cases, and is considered to increase plasma levels of cystatin C. However, this has not been studied in COVID-19. Glomerular filtration rate (GFR) is a clinically important indicator of renal function, but often estimated using equations (eGFR) based on filtered metabolites. This study focuses on sources of bias for eGFRs (mL/min) using a creatinine-based equation (eGFRLMR) and a cystatin C-based equation (eGFRCAPA) in intensive-care-treated patients with COVID-19. This study was performed on 351 patients aged 18 years old or above with severe COVID-19 infections, admitted to the intensive care unit (ICU) in Uppsala University Hospital, a tertiary care hospital in Uppsala, Sweden, between 14 March 2020 and 10 March 2021. Dexamethasone treatment (6 mg for up to 10 days) was introduced 22 June 2020 (n = 232). Values are presented as medians (IQR). eGFRCAPA in dexamethasone-treated patients was 69 (37), and 74 (46) in patients not given dexamethasone (p = 0.01). eGFRLMR was not affected by dexamethasone. eGFRLMR in females was 94 (20), and 75 (38) in males (p = 0.00001). Age and maximal CRP correlated negatively to eGFRCAPA and eGFRLMR, whereas both eGFR equations correlated positively to BMI. In ICU patients with COVID-19, dexamethasone treatment was associated with reduced eGFRCAPA. This finding may be explained by corticosteroid-induced increases in plasma cystatin C. This observation is important from a clinical perspective since adequate interpretation of laboratory results is crucial.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Nyckelord
- COVID-19
- SARS-CoV-2
- biomarkers
- corticosteroids
- creatinine
- cystatin C
- eGFR
- intensive care
- kidney
- biomarkers
- corticosteroids
- COVID-19
- creatinine
- cystatin C
- eGFR
- intensive care
- kidney
- SARS-CoV-2
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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