onr:"swepub:oai:DiVA.org:uu-489508"
Sökning: onr:"swepub:oai:DiVA.org:uu-489508" > Circulating lipopro...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04049naa a2200433 4500 | |
| 001 | oai:DiVA.org:uu-489508 | |
| 003 | SwePub | |
| 008 | 221201s2022 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:154717409 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4895082 URI |
| 024 | 7 | a https://doi.org/10.1016/j.metabol.2022.1553472 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1547174092 URI |
| 040 | a (SwePub)uud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Larsson, Susanna C.u Karolinska Institutet,Uppsala universitet,Medicinsk epidemiologi,Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.4 aut0 (Swepub:uu)susla720 |
| 245 | 1 0 | a Circulating lipoprotein(a) levels and health outcomes :b Phenome-wide Mendelian randomization and disease-trajectory analyses |
| 264 | 1 | b Elsevier,c 2022 |
| 338 | a print2 rdacarrier | |
| 520 | a BACKGROUND: Lipoprotein(a) [Lp(a)] is a risk factor for atherosclerotic and valvular diseases, but its possible role in other diseases has not yet been established. We conducted phenome-wide Mendelian randomization and disease-trajectory analyses to assess any associations of circulating Lp(a) levels with a broad range of diseases.METHODS: A weighted polygenic risk score was constructed using independent genetic variants in the LPA gene and with an established effect on Lp(a) levels. The PheWAS analysis included 1081 phenotype outcomes ascertained among 385,917 White participants of the UK Biobank. Novel findings were investigated in MR analysis using data from the FinnGen consortium. Disease-trajectory and comorbidity analyses were further conducted to explore the sequential patterns of multiple morbidities related to high circulating Lp(a) levels.RESULTS: PheWAS revealed statistically significant associations of higher circulating Lp(a) levels with increased risk of a large number of circulatory system diseases (including various cardiac diseases, peripheral vascular disease, hypertension, and valvular and cerebrovascular diseases) as well as some endocrine/metabolic diseases (including hyperlipidemia, hypercholesterolemia, disorders of lipoid metabolism, and type 2 diabetes), genitourinary system diseases (renal failure), and hematologic diseases (including different types of anemia). Two-sample MR analysis supported the association between Lp(a) and risk of anemia, showed a suggestive association with type 2 diabetes, but found no association with renal failure. Disease-trajectory and comorbidity analyses identified 3 major sequential patterns of multiple morbidities, mainly in the cardiovascular, metabolic, and mental disorders, related to high circulating Lp(a) levels.CONCLUSIONS: Genetically predicted higher circulating Lp(a) levels were associated with increased risk of many circulatory system diseases and anemia. Additionally, this study identified three major sequential patterns of multiple morbidities related to high Lp(a). | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
| 653 | a Anemia | |
| 653 | a Lipoprotein(a) | |
| 653 | a Mendelian randomization | |
| 653 | a PheWAS | |
| 653 | a Type 2 diabetes | |
| 700 | 1 | a Wang, Lijuan4 aut |
| 700 | 1 | a Li, Xue4 aut |
| 700 | 1 | a Jiang, Fangyuan4 aut |
| 700 | 1 | a Chen, Xiangjun4 aut |
| 700 | 1 | a Mantzoros, Christos S4 aut |
| 710 | 2 | a Uppsala universitetb Medicinsk epidemiologi4 org |
| 773 | 0 | t Metabolismd : Elsevierg 137q 137x 0026-0495x 1532-8600 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-489508 |
| 856 | 4 8 | u https://doi.org/10.1016/j.metabol.2022.155347 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:154717409 |
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