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A Rough Colony Morp...
A Rough Colony Morphology of Mycobacterium abscessus Is Associated With Cavitary Pulmonary Disease and Poor Clinical Outcome
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- Hedin, Wilhelm (author)
- Karolinska Univ Hosp, Dept Clin Microbiol, Stockholm, Sweden.
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- Fröberg, Gabrielle (author)
- Karolinska Institutet
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- Fredman, Kalle (author)
- Linköpings universitet,Institutionen för biomedicinska och kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Lungmedicinska kliniken US
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- Chryssanthou, Erja (author)
- Karolinska Univ Hosp, Dept Clin Microbiol, Stockholm, Sweden.
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- Selmeryd, Ingrid (author)
- Vastmanland Hosp, Dept Infect Dis, Västerås, Sweden.
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- Gillman, Anna (author)
- Uppsala universitet,Infektionsmedicin,Uppsala Univ, Sweden
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- Orsini, Letizia (author)
- Karolinska Institutet
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- Runold, Michael (author)
- Karolinska Inst, Dept Med, Div Resp Med & Allergol, Solna, Sweden.
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- Jönsson, Bodil (author)
- Sahlgrens Univ Hosp, Clin Microbiol, Gothenburg, Sweden.
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- Schön, Thomas (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Infektionskliniken i Östergötland
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- Forsman, Lina Davies (author)
- Karolinska Institutet
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Karolinska Institutet Karolinska Univ Hosp, Dept Clin Microbiol, Stockholm, Sweden (creator_code:org_t)
- 2023-01-13
- 2023
- English.
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In: Journal of Infectious Diseases. - : Oxford University Press. - 0022-1899 .- 1537-6613. ; 227:6, s. 820-827
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Abstract
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- Background: The Mycobacterium abscessus complex (MABC) is a difficult to treat mycobacterium with two distinct morphologies: smooth and rough. As the clinical implications are unclear, we explored the morphology of MABC in relation to disease and outcome.Methods: We performed a retrospective multicenter cohort study including patients with confirmed MABC in Sweden, 2009-2020, with treatment outcome as the primary outcome. MABC colony morphology was determined by light microscopy on Middlebrook 7H10 agar plates.Results: Of the 71 MABC isolates, a defined morphology could be determined for 63 isolates, of which 40 were smooth (56%) and 23 were rough (32%). Immunosuppression, pulmonary disease, and cavitary lesion on chest radiographs were significantly associated with a rough isolate morphology. Participants with smooth isolates had more favorable treatment outcomes (12/14, 86%) compared to those with rough isolates (3/10, 30%). In an age-adjusted logistic regression, rough morphology of MABC was associated to lower odds of clinical cure compared to smooth morphology (adjusted odds ratio, 0.12; P = .049).Conclusions: Study participants with rough MABC colony morphology of isolates had a worse clinical outcome compared to those with smooth isolates. The biological mechanisms should be further characterized and colony morphology of MABC taken into account during clinical management.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- nontuberculous mycobacteria
- colony morphology
- Mycobacterium abscessus complex
- subspecies
- treatment outcome
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Hedin, Wilhelm
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Fröberg, Gabriel ...
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Fredman, Kalle
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Chryssanthou, Er ...
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Selmeryd, Ingrid
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Gillman, Anna
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show more...
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Orsini, Letizia
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Runold, Michael
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Jönsson, Bodil
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Schön, Thomas
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Forsman, Lina Da ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
- Articles in the publication
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Journal of Infec ...
- By the university
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Uppsala University
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Linköping University
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Karolinska Institutet