Sökning: onr:"swepub:oai:DiVA.org:uu-502163" > Proteome-wide Mende...
Fältnamn | Indikatorer | Metadata |
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000 | 08181naa a2200685 4500 | |
001 | oai:DiVA.org:uu-502163 | |
003 | SwePub | |
008 | 230522s2023 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:152002535 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5021632 URI |
024 | 7 | a https://doi.org/10.1038/s42255-023-00742-w2 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1520025352 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Yoshiji, Satoshiu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.;McGill Univ, Dept Human Genet, Montreal, PQ, Canada.;Kyoto Univ, Grad Sch Med, Kyoto McGill Int Collaborat Program Genom Med, Kyoto, Japan.;Japan Soc Promot Sci, Tokyo, Japan.4 aut |
245 | 1 0 | a Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity |
264 | c 2023-02-20 | |
264 | 1 | b Springer Nature,c 2023 |
338 | a print2 rdacarrier | |
520 | a How obesity contributes to COVID-19 severity is not fully understood. In this study, Yoshiji et al. found that the plasma protein nephronectin partially mediates the effect of obesity on the risk of COVID-19 severity using a two-step Mendelian randomization approach and omics analyses. Obesity is a major risk factor for Coronavirus disease (COVID-19) severity; however, the mechanisms underlying this relationship are not fully understood. As obesity influences the plasma proteome, we sought to identify circulating proteins mediating the effects of obesity on COVID-19 severity in humans. Here, we screened 4,907 plasma proteins to identify proteins influenced by body mass index using Mendelian randomization. This yielded 1,216 proteins, whose effect on COVID-19 severity was assessed, again using Mendelian randomization. We found that an s.d. increase in nephronectin (NPNT) was associated with increased odds of critically ill COVID-19 (OR = 1.71, P = 1.63 x 10(-10)). The effect was driven by an NPNT splice isoform. Mediation analyses supported NPNT as a mediator. In single-cell RNA-sequencing, NPNT was expressed in alveolar cells and fibroblasts of the lung in individuals who died of COVID-19. Finally, decreasing body fat mass and increasing fat-free mass were found to lower NPNT levels. These findings provide actionable insights into how obesity influences COVID-19 severity. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
700 | 1 | a Butler-Laporte, Guillaumeu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.;McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada.4 aut |
700 | 1 | a Lu, Tianyuanu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.;McGill Univ, Quantitat Life Sci Program, Montreal, PQ, Canada.;5 Prime Sci, Montreal, PQ, Canada.4 aut |
700 | 1 | a Willett, Julian Daniel Sundayu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.;McGill Univ, Quantitat Life Sci Program, Montreal, PQ, Canada.4 aut |
700 | 1 | a Su, Chen-Yangu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.;McGill Univ, Dept Comp Sci, Montreal, PQ, Canada.4 aut |
700 | 1 | a Nakanishi, Tomokou McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.;McGill Univ, Dept Human Genet, Montreal, PQ, Canada.;Kyoto Univ, Grad Sch Med, Kyoto McGill Int Collaborat Program Genom Med, Kyoto, Japan.;Japan Soc Promot Sci, Tokyo, Japan.4 aut |
700 | 1 | a Morrison, David R.u McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.4 aut |
700 | 1 | a Chen, Yihengu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.;McGill Univ, Dept Human Genet, Montreal, PQ, Canada.4 aut |
700 | 1 | a Liang, Kevinu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.;McGill Univ, Quantitat Life Sci Program, Montreal, PQ, Canada.4 aut |
700 | 1 | a Hultström, Michael,d 1978-u Uppsala universitet,Integrativ Fysiologi,Anestesiologi och intensivvård,McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.;McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada.4 aut0 (Swepub:uu)mihul498 |
700 | 1 | a Ilboudo, Yannu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.4 aut |
700 | 1 | a Afrasiabi, Zamanu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.4 aut |
700 | 1 | a Lan, Shanshanu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.4 aut |
700 | 1 | a Duggan, Naomiu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.4 aut |
700 | 1 | a DeLuca, Chantalu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.4 aut |
700 | 1 | a Vaezi, Mitrau McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.4 aut |
700 | 1 | a Tselios, Chrisu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.4 aut |
700 | 1 | a Xue, Xiaoqingu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.4 aut |
700 | 1 | a Bouab, Meriemu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.4 aut |
700 | 1 | a Shi, Fangyiu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.4 aut |
700 | 1 | a Laurent, Laetitiau McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.4 aut |
700 | 1 | a Münter, Hans Markusu McGill Univ, McGill Genome Ctr, Montreal, PQ, Canada.4 aut |
700 | 1 | a Afilalo, Marcu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.;McGill Univ, Jewish Gen Hosp, Dept Emergency Med, Montreal, PQ, Canada.4 aut |
700 | 1 | a Afilalo, Jonathanu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.;McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada.;McGill Univ, Jewish Gen Hosp, Div Cardiol, Montreal, PQ, Canada.4 aut |
700 | 1 | a Mooser, Vincentu McGill Univ, Dept Human Genet, Montreal, PQ, Canada.;McGill Univ, McGill Genome Ctr, Montreal, PQ, Canada.4 aut |
700 | 1 | a Timpson, Nicholas J.u Univ Bristol, MRC Integrat Epidemiol Unit, Bristol, Avon, England.4 aut |
700 | 1 | a Zeberg, Hugou Karolinska Institutet,Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.;Max Planck Inst Evolutionary Anthropol, Leipzig, Germany.4 aut |
700 | 1 | a Zhou, Siruiu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.;McGill Univ, Dept Human Genet, Montreal, PQ, Canada.;McGill Univ, McGill Genome Ctr, Montreal, PQ, Canada.4 aut |
700 | 1 | a Forgetta, Vincenzou McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.;5 Prime Sci, Montreal, PQ, Canada.4 aut |
700 | 1 | a Farjoun, Yossiu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.4 aut |
700 | 1 | a Richards, J. Brentu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.;McGill Univ, Dept Human Genet, Montreal, PQ, Canada.;McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada.;5 Prime Sci, Montreal, PQ, Canada.;Kings Coll London, Dept Twin Res, London, England.4 aut |
710 | 2 | a McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.;McGill Univ, Dept Human Genet, Montreal, PQ, Canada.;Kyoto Univ, Grad Sch Med, Kyoto McGill Int Collaborat Program Genom Med, Kyoto, Japan.;Japan Soc Promot Sci, Tokyo, Japan.b McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.;McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada.4 org |
773 | 0 | t Nature Metabolismd : Springer Natureg 5, s. 248-264q 5<248-264x 2522-5812 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-502163 |
856 | 4 8 | u https://doi.org/10.1038/s42255-023-00742-w |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:152002535 |
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