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The association of ...
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Chiu, Yu-YaoKaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Infect Dis, 100,Tzyou 1st Rd, Kaohsiung 80756, Taiwan.;Kaohsiung Med Univ, Sepsis Res Ctr, Ctr Trop Med & Infect Dis, Sch Med,Grad Inst Med,Coll Med, Kaohsiung, Taiwan.
(författare)
The association of obesity and dengue severity in hospitalized adult patients
- Artikel/kapitelEngelska2023
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Elsevier BV,2023
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LIBRIS-ID:oai:DiVA.org:uu-506990
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-506990URI
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https://doi.org/10.1016/j.jmii.2022.08.008DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Background: Obesity is associated with unfavorable outcomes for infectious diseases. Most researches exploring the association between nutritional status and dengue severity have focused on pediatric populations, with only few studies assessing adult patients.Methods: Adult patients with laboratory-confirmed dengue admitted to a tertiary hospital in southern Taiwan between 2014 and 2015 were enrolled retrospectively. Demographics, comorbidities, clinical presentation, laboratory findings, and outcomes were obtained from caserecord forms. Patients were categorized into obese group and nonobese group. The obese group comprised patients with a body mass index of >= 27.5 kg/m(2).Results: A total of 1417 hospitalized patients with dengue were evaluated. The mean age was 57.9 years (range: 18e92 years). The obese and nonobese groups comprised 333 (23.5%) and 1084 (76.5%) patients, respectively. The obese group included more patients with hypertension (85%, p < 0.001), diabetes mellitus (33%, p < 0.001), and congestive heart failure ( 6.3%, p Z 0.049). Multivariate analysis revealed that the obese group had more petechiae (AOR: 1.353, 95% CI: 1.025e1.786, p Z 0.033), more dyspnea (AOR: 1.380, 95% CI: 1.015e1.876, p Z 0.040), and more severe hepatitis (AOR: 2.061, 95% CI: 1.050e4.048, p Z 0.036). The obese group also had higher peak hematocrit values (44.1%, p < 0.001) and lower nadir platelet count (45.3 x 10(3)/mL, p Z 0.049) than the nonobese group.Conclusion: In adult patients with dengue, obese group had more petechiae, dyspnea, severe hepatitis, lower nadir of platelet count, and higher peak hematocrit level. We observed no difference in severe dengue or mortality between obese and nonobese group.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Lin, Chun-YuUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Anestesiologi och intensivvård,Science for Life Laboratory, SciLifeLab,Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Infect Dis, 100,Tzyou 1st Rd, Kaohsiung 80756, Taiwan.;Kaohsiung Med Univ, Sepsis Res Ctr, Ctr Trop Med & Infect Dis, Sch Med,Grad Inst Med,Coll Med, Kaohsiung, Taiwan.;Kaohsiung Municipal Minsheng Hosp, Kaohsiung, Taiwan.(Swepub:uu)chuli862
(författare)
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Yu, Ling-ShanNatl Sun Yat Sen Univ, Inst BioPharmaceut Sci, Kaohsiung, Taiwan.
(författare)
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Wang, Wen-HungKaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Infect Dis, 100,Tzyou 1st Rd, Kaohsiung 80756, Taiwan.;Kaohsiung Med Univ, Sepsis Res Ctr, Ctr Trop Med & Infect Dis, Sch Med,Grad Inst Med,Coll Med, Kaohsiung, Taiwan.
(författare)
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Huang, Chung-HaoKaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Infect Dis, 100,Tzyou 1st Rd, Kaohsiung 80756, Taiwan.;Kaohsiung Med Univ, Sepsis Res Ctr, Ctr Trop Med & Infect Dis, Sch Med,Grad Inst Med,Coll Med, Kaohsiung, Taiwan.
(författare)
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Chen, Yen-HsuKaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Infect Dis, 100,Tzyou 1st Rd, Kaohsiung 80756, Taiwan.;Kaohsiung Med Univ, Sepsis Res Ctr, Ctr Trop Med & Infect Dis, Sch Med,Grad Inst Med,Coll Med, Kaohsiung, Taiwan.;Natl Yang Ming Chiao Tung Univ, Coll Biol Sci & Technol, Dept Biol Sci & Technol, Hsinchu, Taiwan.;Natl Sun Yat Sen Univ, Inst Med Sci & Technol, Coll Med, Sch Med, Kaohsiung, Taiwan.
(författare)
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Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Infect Dis, 100,Tzyou 1st Rd, Kaohsiung 80756, Taiwan.;Kaohsiung Med Univ, Sepsis Res Ctr, Ctr Trop Med & Infect Dis, Sch Med,Grad Inst Med,Coll Med, Kaohsiung, Taiwan.Institutionen för medicinsk biokemi och mikrobiologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION: Elsevier BV56:2, s. 267-2731684-11821995-9133
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