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Caffeine Intake, Pl...
Caffeine Intake, Plasma Caffeine Level, and Kidney Function : A Mendelian Randomization Study
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- Giontella, Alice (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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- de la Harpe, Roxane (author)
- Univ Hosp Lausanne, Dept Med, Unit Internal Med, Rue Bugnon 21, CH-1011 Lausanne, Switzerland.,Lausanne University Hospital
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- Cronje, Helene T. (author)
- Univ Copenhagen, Dept Publ Hlth, Sect Epidemiol, DK-1165 Copenhagen, Denmark.,University of Copenhagen
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- Zagkos, Loukas (author)
- Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London SW7 2BX, England.,Imperial College London
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- Woolf, Benjamin (author)
- Univ Cambridge, Med Res Council Biostat Unit, Cambridge CB2 0SR, England.;Univ Bristol, Med Res Council, Integrat Epidemiol Unit, Bristol BS8 2BN, England.;Univ Bristol, Dept Psychol Sci, Bristol BS8 1TU, England.,University of Bristol,Medical Research Council Biostatistics Unit
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- Larsson, Susanna C. (author)
- Uppsala University,Karolinska Institute,Karolinska Institutet,Uppsala universitet,Medicinsk epidemiologi,Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, S-17177 Stockholm, Sweden.
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- Gill, Dipender (author)
- Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London SW7 2BX, England.,Imperial College London
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(creator_code:org_t)
- MDPI, 2023
- 2023
- English.
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In: Nutrients. - : MDPI. - 2072-6643. ; 15:20
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Abstract
Subject headings
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- Caffeine is a psychoactive substance widely consumed worldwide, mainly via sources such as coffee and tea. The effects of caffeine on kidney function remain unclear. We leveraged the genetic variants in the CYP1A2 and AHR genes via the two-sample Mendelian randomization (MR) framework to estimate the association of genetically predicted plasma caffeine and caffeine intake on kidney traits. Genetic association summary statistics on plasma caffeine levels and caffeine intake were taken from genome-wide association study (GWAS) meta-analyses of 9876 and of >47,000 European ancestry individuals, respectively. Genetically predicted plasma caffeine levels were associated with a decrease in estimated glomerular filtration rate (eGFR) measured using either creatinine or cystatin C. In contrast, genetically predicted caffeine intake was associated with an increase in eGFR and a low risk of chronic kidney disease. The discrepancy is likely attributable to faster metabolizers of caffeine consuming more caffeine-containing beverages to achieve the same pharmacological effect. Further research is needed to distinguish whether the observed effects on kidney function are driven by the harmful effects of higher plasma caffeine levels or the protective effects of greater intake of caffeine-containing beverages, particularly given the widespread use of drinks containing caffeine and the increasing burden of kidney disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- caffeine level
- caffeine intake
- genetically predicted coffee consumption
- causal inference
- Mendelian randomization
- kidney function
- estimated glomerular filtration rate
- caffeine intake
- caffeine level
- causal inference
- estimated glomerular filtration rate
- genetically predicted coffee consumption
- kidney function
- Mendelian randomization
Publication and Content Type
- ref (subject category)
- art (subject category)
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