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Early to mid-pregna...
Early to mid-pregnancy HbA1c levels and its association with adverse pregnancy outcomes in three low middle-income countries in Asia and Sub-Saharan Africa
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- Nisar, Muhammad Imran (författare)
- Aga Khan Univ, Dept Pediat & Child Hlth, Stadium Rd, Karachi 74800, Pakistan.
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- Das, Sayan (författare)
- Ctr Publ Hlth Kinet, New Delhi, India.
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- Khanam, Rasheda (författare)
- Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD USA.
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- Khalid, Javairia (författare)
- Aga Khan Univ, Dept Pediat & Child Hlth, Stadium Rd, Karachi 74800, Pakistan.
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- Chetia, Swagata (författare)
- Ctr Publ Hlth Kinet, New Delhi, India.
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- Hasan, Tarik (författare)
- Projahnmo Res Fdn, Dhaka, Bangladesh.
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- Shahid, Shahira (författare)
- Aga Khan Univ, Dept Pediat & Child Hlth, Stadium Rd, Karachi 74800, Pakistan.
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- Marijani, Msafiri Ladislaus (författare)
- Minist Hlth, Zanzibar, Tanzania.
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- Ahmed, Salahuddin (författare)
- Projahnmo Res Fdn, Dhaka, Bangladesh.
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- Khalid, Farah (författare)
- Aga Khan Univ, Dept Pediat & Child Hlth, Stadium Rd, Karachi 74800, Pakistan.
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- Ali, Said Mohammed (författare)
- Publ Hlth Lab, IDC, Pemba, Tanzania.
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- Chowdhury, Nabidul Haque (författare)
- Projahnmo Res Fdn, Dhaka, Bangladesh.
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- Mehmood, Usma (författare)
- Aga Khan Univ, Dept Pediat & Child Hlth, Stadium Rd, Karachi 74800, Pakistan.
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- Dutta, Arup (författare)
- Ctr Publ Hlth Kinet, New Delhi, India.
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- Rahman, Sayedur (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa
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- Qazi, Muhammad Farrukh (författare)
- Aga Khan Univ, Dept Pediat & Child Hlth, Stadium Rd, Karachi 74800, Pakistan.
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- Deb, Saikat (författare)
- Ctr Publ Hlth Kinet, New Delhi, India.;Publ Hlth Lab, IDC, Pemba, Tanzania.
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- Mitra, Dipak Kumar (författare)
- North South Univ, Sch Hlth & Life Sci, Dept Publ Hlth, Dhaka, Bangladesh.
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- Usmani, Asra Abeer (författare)
- Aga Khan Univ, Dept Pediat & Child Hlth, Stadium Rd, Karachi 74800, Pakistan.
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- Dhingra, Usha (författare)
- Ctr Publ Hlth Kinet, New Delhi, India.
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- Raqib, Rubhana (författare)
- Int Ctr Diarrheal Dis Res, Dhaka, Bangladesh.
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- Manu, Alexander (författare)
- Trop Med Fac Epidemiol & Publ Hlth, London Sch Hyg, London, England.
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- Yoshida, Sachiyo (författare)
- World Hlth Org, MCA MRD, Dept Maternal Child Adolescents & Ageing Hlth, Ave Appia 20, CH-1211 Geneva, Switzerland.
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- Minckas, Nicole (författare)
- World Hlth Org, MCA MRD, Dept Maternal Child Adolescents & Ageing Hlth, Ave Appia 20, CH-1211 Geneva, Switzerland.
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- Bahl, Rajiv (författare)
- World Hlth Org, MCA MRD, Dept Maternal Child Adolescents & Ageing Hlth, Ave Appia 20, CH-1211 Geneva, Switzerland.
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- Baqui, Abdullah H. (författare)
- Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD USA.
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- Sazawal, Sunil (författare)
- Ctr Publ Hlth Kinet, New Delhi, India.
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- Jehan, Fyezah (författare)
- Aga Khan Univ, Dept Pediat & Child Hlth, Stadium Rd, Karachi 74800, Pakistan.
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Aga Khan Univ, Dept Pediat & Child Hlth, Stadium Rd, Karachi 74800, Pakistan Ctr Publ Hlth Kinet, New Delhi, India. (creator_code:org_t)
- BioMed Central (BMC), 2024
- 2024
- Engelska.
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Ingår i: BMC Pregnancy and Childbirth. - : BioMed Central (BMC). - 1471-2393. ; 24:1
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Hyperglycemia during pregnancy leads to adverse maternal and fetal outcomes. Thus, strict monitoring of blood glucose levels is warranted. This study aims to determine the association of early to mid-pregnancy HbA1c levels with the development of pregnancy complications in women from three countries in South Asia and Sub-Saharan Africa.Methods: We performed a secondary analysis of the AMANHI (Alliance for Maternal and Newborn Health Improvement) cohort, which enrolled 10,001 pregnant women between May 2014 and June 2018 across Sylhet-Bangladesh, Karachi-Pakistan, and Pemba Island-Tanzania. HbA1c assays were performed at enrollment (8 to < 20 gestational weeks), and epidemiological data were collected during 2-3 monthly household visits. The women were followed-up till the postpartum period to determine the pregnancy outcomes. Multivariable logistic regression models assessed the association between elevated HbA1c levels and adverse events while controlling for potential confounders.Results: A total of 9,510 pregnant women were included in the analysis. The mean HbA1c level at enrollment was found to be the highest in Bangladesh (5.31 +/- 0.37), followed by Tanzania (5.22 +/- 0.49) and then Pakistan (5.07 +/- 0.58). We report 339 stillbirths and 9,039 live births. Among the live births were 892 preterm births, 892 deliveries via cesarean section, and 532 LGA babies. In the multivariate pooled analysis, maternal HbA1c levels of >= 6.5 were associated with increased risks of stillbirths (aRR = 6.3, 95% CI = 3.4,11.6); preterm births (aRR = 3.5, 95% CI = 1.8-6.7); and Large for Gestational Age (aRR = 5.5, 95% CI = 2.9-10.6).Conclusion: Maternal HbA1c level is an independent risk factor for predicting adverse pregnancy outcomes such as stillbirth, preterm birth, and LGA among women in South Asia and Sub-Saharan Africa. These groups may benefit from early interventional strategies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- HbA1c
- First trimester
- Gestational Diabetes Mellitus
- Adverse pregnancy outcomes
- South Asia
- Sub-Saharan Africa
- LMICs
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Nisar, Muhammad ...
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Das, Sayan
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Khanam, Rasheda
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Khalid, Javairia
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Chetia, Swagata
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Hasan, Tarik
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visa fler...
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Shahid, Shahira
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Marijani, Msafir ...
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Ahmed, Salahuddi ...
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Khalid, Farah
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Ali, Said Mohamm ...
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Chowdhury, Nabid ...
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Mehmood, Usma
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Dutta, Arup
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Rahman, Sayedur
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Qazi, Muhammad F ...
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Deb, Saikat
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Mitra, Dipak Kum ...
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Usmani, Asra Abe ...
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Dhingra, Usha
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Raqib, Rubhana
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Manu, Alexander
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Yoshida, Sachiyo
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Minckas, Nicole
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Bahl, Rajiv
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Baqui, Abdullah ...
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Sazawal, Sunil
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Jehan, Fyezah
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BMC Pregnancy an ...
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Uppsala universitet