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Polycystic ovary syndrome and risk of pre‐eclampsia : A national register‐based cohort study
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- Valdimarsdottir, Ragnheidur (author)
- Uppsala universitet,Reproduktiv hälsa
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- Vanky, Eszter (author)
- Department of Clinical and Molecular Medicine Norwegian University of Science and Technology Trondheim Norway;Department of Obstetrics and Gynaecology St. Olavs Hospital, Trondheim University Hospital Trondheim Norway
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- Elenis, Evangelia, 1983- (author)
- Uppsala universitet,Reproduktiv hälsa
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- John Wiley & Sons, 2023
- 2023
- English.
- In: British Journal of Obstetrics and Gynecology. - : John Wiley & Sons. - 1470-0328 .- 1471-0528.
- Journal article (peer-reviewed)
Abstract
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- Objective: To explore whether the association between polycystic ovary syndrome (PCOS) and pre-eclampsia depends on treated clinical hyperandrogenism and whether PCOS is associated with different subtypes of pre-eclampsia.Design: Nationwide register-based cohort study.Setting: Sweden.Population: Nulliparous women with PCOS (n = 22 947) and non-PCOS controls (n = 115 272) giving singleton birth at ≥22 gestational weeks during 1997-2015. Treated clinical hyperandrogenism was defined as filled prescriptions of anti-androgenic drugs during 2005-2017 (n = 2301 among PCOS women).Methods: The risk of pre-eclampsia was estimated with conditional logistic regression, expressed as adjusted odds ratio (OR) with 95% confidence interval (CI). Adjustments were performed individually for confounders and predictors.Main outcome measures: Overall pre-eclampsia. Early/late (delivery <34/≥34 weeks) pre-eclampsia. Pre-eclampsia with or without a small-for-gestational-age (SGA) infant.Results: Compared with controls, women with PCOS had a 29% increased risk of pre-eclampsia (predictor adjusted OR 1.29, 95% CI 1.20-1.39), with similar risk estimates for PCOS women with and without treated clinical hyperandrogenism. The association between PCOS and early pre-eclampsia seemed stronger than its association with late pre-eclampsia (predictor adjusted OR 1.64 (95% CI 1.33-2.02) and 1.26 (95% CI 1.17-1.37). Additionally, the association seemed slightly stronger between PCOS and pre-eclampsia in women with an SGA infant than without.Conclusions: Women with PCOS face an increased risk for pre-eclampsia, especially early pre-eclampsia and pre-eclampsia with an SGA infant. We were unable to determine on the basis of available data, whether hyperandrogenism is associated with pre-eclampsia.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- hyperandrogenism
- polycystic ovary syndrome
- pre-eclampsia
- pregnancy complications
- preterm birth
- small for gestational age.
- Obstetrik och gynekologi
- Obstetrics and Gynaecology
Publication and Content Type
- ref (subject category)
- art (subject category)
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