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Sökning: onr:"swepub:oai:DiVA.org:uu-524742" > Polycystic ovary sy...

  • Valdimarsdottir, RagnheidurUppsala universitet,Reproduktiv hälsa (författare)

Polycystic ovary syndrome and risk of pre‐eclampsia : A national register‐based cohort study

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • John Wiley & Sons,2023
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-524742
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-524742URI
  • https://doi.org/10.1111/1471-0528.17734DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Objective: To explore whether the association between polycystic ovary syndrome (PCOS) and pre-eclampsia depends on treated clinical hyperandrogenism and whether PCOS is associated with different subtypes of pre-eclampsia.Design: Nationwide register-based cohort study.Setting: Sweden.Population: Nulliparous women with PCOS (n = 22 947) and non-PCOS controls (n = 115 272) giving singleton birth at ≥22 gestational weeks during 1997-2015. Treated clinical hyperandrogenism was defined as filled prescriptions of anti-androgenic drugs during 2005-2017 (n = 2301 among PCOS women).Methods: The risk of pre-eclampsia was estimated with conditional logistic regression, expressed as adjusted odds ratio (OR) with 95% confidence interval (CI). Adjustments were performed individually for confounders and predictors.Main outcome measures: Overall pre-eclampsia. Early/late (delivery <34/≥34 weeks) pre-eclampsia. Pre-eclampsia with or without a small-for-gestational-age (SGA) infant.Results: Compared with controls, women with PCOS had a 29% increased risk of pre-eclampsia (predictor adjusted OR 1.29, 95% CI 1.20-1.39), with similar risk estimates for PCOS women with and without treated clinical hyperandrogenism. The association between PCOS and early pre-eclampsia seemed stronger than its association with late pre-eclampsia (predictor adjusted OR 1.64 (95% CI 1.33-2.02) and 1.26 (95% CI 1.17-1.37). Additionally, the association seemed slightly stronger between PCOS and pre-eclampsia in women with an SGA infant than without.Conclusions: Women with PCOS face an increased risk for pre-eclampsia, especially early pre-eclampsia and pre-eclampsia with an SGA infant. We were unable to determine on the basis of available data, whether hyperandrogenism is associated with pre-eclampsia.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Vanky, EszterDepartment of Clinical and Molecular Medicine Norwegian University of Science and Technology Trondheim Norway;Department of Obstetrics and Gynaecology St. Olavs Hospital, Trondheim University Hospital Trondheim Norway (författare)
  • Elenis, Evangelia,1983-Uppsala universitet,Reproduktiv hälsa(Swepub:uu)evael941 (författare)
  • Lindström, Linda,1978-Uppsala universitet,Klinisk obstetrik(Swepub:uu)linli329 (författare)
  • Junus, Katja,1982-Uppsala universitet,Klinisk obstetrik(Swepub:uu)katju360 (författare)
  • Jonsson, Maria,1966-Uppsala universitet,Klinisk obstetrik(Swepub:uu)marjo155 (författare)
  • Sundström Poromaa, Inger,1964-Uppsala universitet,Reproduktiv hälsa(Swepub:uu)inspo702 (författare)
  • Wikström, Anna-Karin,1965-Uppsala universitet,Klinisk obstetrik(Swepub:uu)annwi179 (författare)
  • Uppsala universitetReproduktiv hälsa (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:British Journal of Obstetrics and Gynecology: John Wiley & Sons1470-03281471-0528

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