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Bariatric Surgery I...
Bariatric Surgery Induces Alterations in the Immune Profile of Peripheral Blood T Cells
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- Barbosa, Pedro (författare)
- Univ Coimbra, Inst Interdisciplinary Res, Doctoral Programme Expt Biol & Biomed PDBEB, P-3030789 Coimbra, Portugal.;Univ Coimbra, Ctr Neurosci & Cell Biol CNC, P-3004504 Coimbra, Portugal.;Univ Coimbra, Inst Interdisciplinary Res IIIUC, P-3030789 Coimbra, Portugal.;Univ Coimbra, Ctr Innovat Biomed & Biotechnol CIBB, P-3000504 Coimbra, Portugal.
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- Pinho, Aryane (författare)
- Univ Coimbra, Ctr Neurosci & Cell Biol CNC, P-3004504 Coimbra, Portugal.;Univ Coimbra, Ctr Innovat Biomed & Biotechnol CIBB, P-3000504 Coimbra, Portugal.;Univ Coimbra, Dept Life Sci, P-3000456 Coimbra, Portugal.
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- Lazaro, Andre (författare)
- Ctr Hosp & Univ Coimbra, Gen Surg Unit, P-3000075 Coimbra, Portugal.;Clin Acad Ctr Coimbra CACC, P-3004061 Coimbra, Portugal.;Univ Coimbra, Coimbra Inst Clin & Biomed Res iCBR, Fac Med FMUC, Grp Environm Genet Oncobiol CIMAGO, P-3000548 Coimbra, Portugal.
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- Paula, Diogo (författare)
- Ctr Hosp & Univ Coimbra, Gen Surg Unit, P-3000075 Coimbra, Portugal.;Clin Acad Ctr Coimbra CACC, P-3004061 Coimbra, Portugal.
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- Tralhao, Jose G. (författare)
- Ctr Hosp & Univ Coimbra, Gen Surg Unit, P-3000075 Coimbra, Portugal.;Clin Acad Ctr Coimbra CACC, P-3004061 Coimbra, Portugal.;Univ Coimbra, Coimbra Inst Clin & Biomed Res iCBR, Fac Med FMUC, Grp Environm Genet Oncobiol CIMAGO, P-3000548 Coimbra, Portugal.;Univ Coimbra, Inst Biophys, Fac Med, P-3000548 Coimbra, Portugal.
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- Paiva, Artur (författare)
- Univ Coimbra, Ctr Innovat Biomed & Biotechnol CIBB, P-3000504 Coimbra, Portugal.;Clin Acad Ctr Coimbra CACC, P-3004061 Coimbra, Portugal.;Univ Coimbra, Coimbra Inst Clin & Biomed Res iCBR, Fac Med FMUC, Grp Environm Genet Oncobiol CIMAGO, P-3000548 Coimbra, Portugal.;Ctr Hosp & Univ Coimbra, Dept Clin Pathol, Flow Cytometry Unit, P-3000076 Coimbra, Portugal.;Inst Politecn Coimbra, ESTESC Coimbra Hlth Sch, Ciencias Biomed Labs, P-3046854 Coimbra, Portugal.
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- Pereira, Maria J., 1981- (författare)
- Uppsala universitet,Klinisk diabetologi och metabolism
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- Carvalho, Eugenia (författare)
- Univ Coimbra, Ctr Neurosci & Cell Biol CNC, P-3004504 Coimbra, Portugal.;Univ Coimbra, Inst Interdisciplinary Res IIIUC, P-3030789 Coimbra, Portugal.;Univ Coimbra, Ctr Innovat Biomed & Biotechnol CIBB, P-3000504 Coimbra, Portugal.
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- Laranjeira, Paula (författare)
- Univ Coimbra, Ctr Neurosci & Cell Biol CNC, P-3004504 Coimbra, Portugal.;Univ Coimbra, Ctr Innovat Biomed & Biotechnol CIBB, P-3000504 Coimbra, Portugal.;Clin Acad Ctr Coimbra CACC, P-3004061 Coimbra, Portugal.;Univ Coimbra, Coimbra Inst Clin & Biomed Res iCBR, Fac Med FMUC, Grp Environm Genet Oncobiol CIMAGO, P-3000548 Coimbra, Portugal.;Ctr Hosp & Univ Coimbra, Dept Clin Pathol, Flow Cytometry Unit, P-3000076 Coimbra, Portugal.
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Univ Coimbra, Inst Interdisciplinary Res, Doctoral Programme Expt Biol & Biomed PDBEB, P-3030789 Coimbra, Portugal;Univ Coimbra, Ctr Neurosci & Cell Biol CNC, P-3004504 Coimbra, Portugal.;Univ Coimbra, Inst Interdisciplinary Res IIIUC, P-3030789 Coimbra, Portugal.;Univ Coimbra, Ctr Innovat Biomed & Biotechnol CIBB, P-3000504 Coimbra, Portugal. Univ Coimbra, Ctr Neurosci & Cell Biol CNC, P-3004504 Coimbra, Portugal.;Univ Coimbra, Ctr Innovat Biomed & Biotechnol CIBB, P-3000504 Coimbra, Portugal.;Univ Coimbra, Dept Life Sci, P-3000456 Coimbra, Portugal. (creator_code:org_t)
- MDPI, 2024
- 2024
- Engelska.
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Ingår i: Biomolecules. - : MDPI. - 2218-273X. ; 14:2
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Low-grade inflammation is closely linked to obesity and obesity-related comorbidities; therefore, immune cells have become an important topic in obesity research. Here, we performed a deep phenotypic characterization of circulating T cells in people with obesity, using flow cytometry. Forty-one individuals with obesity (OB) and clinical criteria for bariatric surgery were enrolled in this study. We identified and quantified 44 different circulating T cell subsets and assessed their activation status and the expression of immune-checkpoint molecules, immediately before (T1) and 7-18 months after (T2) the bariatric surgery. Twelve age- and sex-matched healthy individuals (nOB) were also recruited. The OB participants showed higher leukocyte counts and a higher percentage of neutrophils. The percentage of circulating Th1 cells were negatively correlated to HbA1c and insulin levels. OB Th1 cells displayed a higher activation status and lower PD-1 expression. The percentage of Th17 and Th1/17 cells were increased in OB, whereas the CD4+ Tregs' percentage was decreased. Interestingly, a higher proportion of OB CD4+ Tregs were polarized toward Th1- and Th1/17-like cells and expressed higher levels of CCR5. Bariatric surgery induced the recovery of CD4+ Treg cell levels and the expansion and activation of Tfh and B cells. Our results show alterations in the distribution and phenotype of circulating T cells from OB people, including activation markers and immune-checkpoint proteins, demonstrating that different metabolic profiles are associated to distinct immune profiles, and both are modulated by bariatric surgery.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- T cells
- Treg
- obesity
- bariatric surgery
- insulin resistance
- immune phenotype
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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