Sökning: onr:"swepub:oai:DiVA.org:uu-527996" > Exploring the chemi...
Fältnamn | Indikatorer | Metadata |
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000 | 02975naa a2200385 4500 | |
001 | oai:DiVA.org:uu-527996 | |
003 | SwePub | |
008 | 240516s2024 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5279962 URI |
024 | 7 | a https://doi.org/10.1016/j.drudis.2024.1039172 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a for2 swepub-publicationtype |
100 | 1 | a Apprato, Giuliau Univ Torino, Dept Mol Biotechnol & Hlth Sci, Piazza Nizza 44bis, I-10126 Turin, Italy.4 aut |
245 | 1 0 | a Exploring the chemical space of orally bioavailable PROTACs |
264 | 1 | b Elsevier,c 2024 |
338 | a electronic2 rdacarrier | |
520 | a A principal challenge in the discovery of proteolysis targeting chimeras (PROTACs) as oral medications is their bioavailability. To facilitate drug design, it is therefore essential to identify the chemical space where orally bioavailable PROTACs are more likely to be situated. To this aim, we extracted structure-bioavailability insights from published data using traditional 2D descriptors, thereby shedding light on their potential and limitations as drug design tools. Subsequently, we describe cuttingedge experimental, computational and hybrid design strategies based on 3D descriptors, which show promise for enhancing the probability of discovering PROTACs with high oral bioavailability. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmaceutiska vetenskaper0 (SwePub)301012 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmaceutical Sciences0 (SwePub)301012 hsv//eng |
700 | 1 | a Poongavanam, Vasanthanathanu Uppsala universitet,Organisk kemi4 aut0 (Swepub:uu)vaspo224 |
700 | 1 | a Jimenez, Diego Garciau Univ Torino, Dept Mol Biotechnol & Hlth Sci, Piazza Nizza 44bis, I-10126 Turin, Italy.4 aut |
700 | 1 | a Atilaw, Yosephu Uppsala universitet,Organisk kemi4 aut0 (Swepub:uu)yosat333 |
700 | 1 | a Erdélyi, Máté,d 1975-u Uppsala universitet,Organisk kemi4 aut0 (Swepub:uu)mateerde |
700 | 1 | a Ermondi, Giuseppeu Univ Torino, Dept Mol Biotechnol & Hlth Sci, Piazza Nizza 44bis, I-10126 Turin, Italy.4 aut |
700 | 1 | a Caron, Giuliau Univ Torino, Dept Mol Biotechnol & Hlth Sci, Piazza Nizza 44bis, I-10126 Turin, Italy.4 aut |
700 | 1 | a Kihlberg, Janu Uppsala universitet,Organisk kemi4 aut0 (Swepub:uu)janki643 |
710 | 2 | a Univ Torino, Dept Mol Biotechnol & Hlth Sci, Piazza Nizza 44bis, I-10126 Turin, Italy.b Organisk kemi4 org |
773 | 0 | t Drug Discovery Todayd : Elsevierg 29:4q 29:4x 1359-6446x 1878-5832 |
856 | 4 | u https://doi.org/10.1016/j.drudis.2024.103917y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1858377/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-527996 |
856 | 4 8 | u https://doi.org/10.1016/j.drudis.2024.103917 |
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