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A mathematical mode...
A mathematical model for temporal cerebral blood flow response to acetazolamide evaluated in patients with Moyamoya disease
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- Fahlström, Markus (författare)
- Uppsala universitet,Molekylär avbildning och medicinsk fysik,Uppsala Univ Hosp, Med Phys, Uppsala, Sweden
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- Sousa, Joao M., 1989- (författare)
- Uppsala universitet,Molekylär avbildning och medicinsk fysik,Uppsala Univ Hosp, Med Phys, Uppsala, Sweden
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- Svedung Wettervik, Teodor (författare)
- Uppsala universitet,Neurokirurgi
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- Berglund, Johan (författare)
- Uppsala universitet,Molekylär avbildning och medicinsk fysik,Uppsala Univ Hosp, Med Phys, Uppsala, Sweden
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- Enblad, Per (författare)
- Uppsala universitet,Neurokirurgi
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- Lewén, Anders, 1965- (författare)
- Uppsala universitet,Neurokirurgi
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- Wikström, Johan, Professor, 1964- (författare)
- Uppsala universitet,Neuroradiologi
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(creator_code:org_t)
- Elsevier, 2024
- 2024
- Engelska.
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Ingår i: Magnetic Resonance Imaging. - : Elsevier. - 0730-725X .- 1873-5894. ; 110, s. 35-42
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Paired cerebral blood flow (CBF) measurement is usually acquired before and after vasoactive stimulus to estimate cerebrovascular reserve (CVR). However, CVR may be confounded because of variations in time-to-maximum CBF response (tmax) following acetazolamide injection. With a mathematical model, CVR can be calculated insensitive to variations in tmax, and a model offers the possibility to calculate additional model-derived parameters. A model that describes the temporal CBF response following a vasodilating acetazolamide injection is proposed and evaluated.Methods: A bi-exponential model was adopted and fitted to four CBF measurements acquired using arterial spin labelling before and initialised at 5, 15 and 25 min after acetazolamide injection in a total of fifteen patients with Moyamoya disease. Curve fitting was performed using a non-linear least squares method with a priori constraints based on simulations.Results: Goodness of fit (mean absolute error) varied between 0.30 and 0.62 ml·100 g-1·min-1. Model-derived CVR was significantly higher compared to static CVR measures. Maximum CBF increase occurred earlier in healthy- compared to diseased vascular regions.Conclusions: The proposed mathematical model offers the possibility to calculate CVR insensitive to variations in time to maximum CBF response which gives a more detailed characterisation of CVR compared to static CVR measures. Although the mathematical model adapts generally well to this dataset of patients with MMD it should be considered as experimental; hence, further studies in healthy populations and other patient cohorts are warranted.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Acetazolamide
- Cerebral blood flow
- Cerebrovascular reserve
- Modelling
- Moyamoya disease
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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