Change in tissue resistance after irreversible electroporation in liver tumors as an indicator of treatment success: A multi-center analysis with long term follow-up

Change in tissue resistance after irreversible electroporation in liver tumors as an indicator of treatment success : A multi-center analysis with long term follow-up

Frühling, Petter (författare): Uppsala universitet,Institutionen för kirurgiska vetenskaper

Stillström, David (författare): Danderyd Hosp, Karolinska Inst, Dept Clin Sci, Div Surg, Stockholm, Sweden.

Holmquist, Fredrik (författare): Skane Univ Hosp, Dept Med Imaging & Physiol, Lund, Sweden.

Nilsson, Anders (författare): Skane Univ Hosp, Dept Med Imaging & Physiol, Lund, Sweden.

Freedman, Jacob (författare): Danderyd Hosp, Karolinska Inst, Dept Clin Sci, Div Surg, Stockholm, Sweden.

(creator_code:org_t)

Elsevier, 2024
2024
Engelska.
Ingår i: European Journal of Surgical Oncology. - : Elsevier. - 0748-7983 .- 1532-2157. ; 50:9

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Abstract Ämnesord

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IntroductionA nationwide multicenter study was performed to examine whether there is a correlation between decrease in tissue resistance and time to local tumor recurrence after irreversible electroporation (IRE) in patients with hepatocellular carcinoma (HCC) and colorectal cancer liver metastases (CRCLM).MethodsAll patients treated with IRE for liver tumors in Sweden from 2011 until 2018 were included. Patient characteristics and recurrence patterns were obtained from medical records and radiological imaging. All procedural data from the IRE hardware at the three hospitals performing IRE were retrieved. The resistance during each pulse and the change during each treatment were calculated. The electrode pair with the smallest decrease in tissue resistance was used and compared with the time to LTP.Results149 patients with 206 tumors were treated. Exclusion due to missing and inaccurate data resulted in 124 patients with 170 tumors for the analyses. In a multivariable Cox regression model, a smaller decrease in tissue resistance and larger tumor size were associated with shorter time to local tumor recurrence for CRCLM, but not for HCC.ConclusionThere was an association between a decrease in tissue resistance and time to local tumor recurrence for CRCLM. The decrease in resistance, in combination with a rise in current, may be the parameters the interventionist should use during IRE to decide if the treatment is successful.

Av författaren/redakt...: Frühling, Petter; Stillström, Davi ...; Holmquist, Fredr ...; Nilsson, Anders; Freedman, Jacob

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kirurgi

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