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Targeted superantigens for immunotherapy of haematopoietic tumours
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- Tötterman, Thomas H. (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,KITM
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- Gidlöf, C. (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,KITM
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- Ragnarsson, L. (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,KITM
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- Lindeberg, M. (author)
- von der Lehr, N. (author)
- Soegaard, M. (author)
- Kristensson, K. (author)
- Kalland, T. (author)
- Dohlsten, M. (author)
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- (creator_code:org_t)
- 1998
- 1998
- English.
- In: Vox Sanguinis. - 0042-9007 .- 1423-0410. ; 74:Supp 2, s. 483-487
- Journal article (peer-reviewed)
Abstract
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- With the exception of childhood common acute lymphoblastic leukaemia (cALL), treatment of other hematopoietic B cell lineage tumours such as non-Hodgkin's lymphoma (B-NHL), adult ALL and multiple myeloma (MM) is unsatisfactory. Similarly, the therapeutic outcome of acute and chronic myeloid leukaemia (AML, CML) is frequently dismal. At the same time, leukaemia/lymphoma cells represent ideal targets for immunotherapy. The present review summarizes our preclinical experience with a novel type of cytotoxic T cell based immunotherapy for B-lineage and myeloid tumours. Staphylococcal enterotoxin-derived superantigens (SAgs) are among the most potent T cell activators known, linking the T cell receptor to HLA-DR on natural target cells. SAgs were genetically engineered to reduce DR binding and were then fused to Fab parts of tumour-directed monoclonal antibodies (mAbs). Using these "targeted" SAgs, highly efficient lysis of B-lineage (B-NHL, B-CLL, ALL, MM) and myeloid (AML, CML) tumour cells by T-cells was achieved in vitro and in an animal model. We are entering an interesting era of innovative cancer therapy based on novel man-made biotherapeutic agents.
Keyword
- MEDICINE
- MEDICIN
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- ref (subject category)
- art (subject category)
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- Gidlöf, C.
- Ragnarsson, L.
- Högbom, E.
- Lindeberg, M.
- von der Lehr, N.
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- Einarsson, A.
- Soegaard, M.
- Kristensson, K.
- Kalland, T.
- Dohlsten, M.
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