Sökning: onr:"swepub:oai:DiVA.org:uu-62596" > Effects of melanoco...
Fältnamn | Indikatorer | Metadata |
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000 | 03455naa a2200469 4500 | |
001 | oai:DiVA.org:uu-62596 | |
003 | SwePub | |
008 | 081017s2002 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-625962 URI |
024 | 7 | a https://doi.org/10.1016/S0361-9230(02)00844-42 DOI |
040 | a (SwePub)uu | |
041 | a engb engb -1 | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Ploj, Karolinau Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Pharmacology4 aut |
245 | 1 0 | a Effects of melanocortin receptor ligands on ethanol intake and opioid peptide levels in alcohol-preferring AA rats |
264 | 1 | c 2002 |
338 | a print2 rdacarrier | |
520 | a Melanocortin (MC) peptides are suggested to play a role in opiate dependence, where they antagonise the addictive properties of opiates. To further study the involvement of the MCs in drug dependence, we analysed the effects of the MC(4)-receptor antagonist HS014 (1 nmol/rat), and the non-selective MC-receptor agonist MTII (1 nmol/rat), using i.c.v. administration, on ethanol intake in alcohol-preferring AA rats. The rats had access to ethanol during 40 days, resulting in a mean ethanol intake of 6.6 g/kg/day, before treatment. One group received only artificial cerebrospinal fluid solution. MTII caused a reduction in ethanol intake and ethanol preference, whereas HS014 was without effect. No effect on water intake was observed. A decrease in food intake was detected after MTII, whereas HS014 induced an increase in food intake. Analysis of dynorphin B and Met-enkephalin-Arg(6)Phe(7) immunoreactive levels revealed that MTII and HS014 altered opioid peptide levels in several brain areas and the pituitary gland of the rats with an established ethanol intake. This is the first report showing that manipulation of the MC-receptor system changes ethanol intake in chronically ethanol-drinking AA rats. In addition, manipulation of the MC system modulates ethanol-induced changes in opioid peptide levels. | |
520 | a | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmaceutiska vetenskaper0 (SwePub)301012 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmaceutical Sciences0 (SwePub)301012 hsv//eng |
653 | a alcohol-preferring rats | |
653 | a HS014 | |
653 | a MTII | |
653 | a dynorphin B | |
653 | a Met-enkephalin-Arg(6)Phe(7) | |
653 | a PHARMACY | |
653 | a FARMACI | |
653 | a MEDICINE | |
653 | a MEDICIN | |
700 | 1 | a Roman, Erikau Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Pharmacology4 aut0 (Swepub:uu)errom351 |
700 | 1 | a Kask, Ants4 aut |
700 | 1 | a Hyytiä, Petri4 aut |
700 | 1 | a Schiöth, Helgi Bu Uppsala universitet,Farmakologi4 aut |
700 | 1 | a Wikberg, Jarl E Su Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Pharmacology4 aut |
700 | 1 | a Nylander, Ingridu Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Pharmacology4 aut0 (Swepub:uu)iny08577 |
710 | 2 | a Uppsala universitetb Institutionen för farmaceutisk biovetenskap4 org |
773 | 0 | t Brain Research Bulleting 59:2, s. 97-104q 59:2<97-104x 0361-9230x 1873-2747 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-62596 |
856 | 4 8 | u https://doi.org/10.1016/S0361-9230(02)00844-4 |
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